Abstract：
:The objective of the present study was to characterize the trkB receptor immunoreactive (-ir) cells in the intermediolateral cell column (IML) of the upper thoracic spinal cord. Small trkB-ir cells (area=56.1+/-4.4 microm(2)) observed in the IML showed characteristics of oligodendrocytes and were frequently observed in close apposition to choline acetyltransferase (ChAT)-ir cell bodies. Large trkB-ir cells (area=209.3+/-25.2 microm(2)) showed immunoreactivity for the neuronal marker NeuN, indicating their neuronal phenotype, as well as for ChAT, a marker for preganglionic neurons. TrkB and ChAT were co-localized in IML neurons primarily in cases that had received in vivo administration of nerve growth factor (NGF). These findings reveal two different cell types, oligodendrocytes and neurons, in the IML of the spinal cord that show trkB immunoreactivity, suggesting their regulation by brain derived neurotrophic factor (BDNF) and/or neurotrophin-4 (NT-4). In addition, there is evidence that NGF may play a role in the regulation of trkB-ir preganglionic neurons in the IML.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
McCartney AM,Abejuela VL,Isaacson LGdoi
10.1016/j.neulet.2008.05.057subject
Has Abstractpub_date
2008-08-01 00:00:00pages
103-8issue
2eissn
0304-3940issn
1872-7972pii
S0304-3940(08)00658-7journal_volume
440pub_type
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