Abstract:
:Glutamic acid (Glu) participates in pain modulation of the central nervous system. The CA3 region of the hippocampal formation has been suggested to be involved in nociceptive perception. However, it is unknown whether Glu could modulate the electrical activities of pain-related neurons in the hippocampal CA3 region. The present study aimed to determine the effects of Glu and its receptor antagonist MK-801 in the pain-evoked response of both pain-excited neurons (PENs) and pain-inhibited neurons (PINs) in the hippocampal CA3 region of normal rats. We used a train of electric impulses applied to the sciatic nerve as noxious stimulation. The electrical activities of either PENs or PINs in the hippocampal CA3 region were recorded by a glass microelectrode. The results revealed that intra-CA3 region microinjection of Glu (0.5 μg/1 μl) increased the evoked firing frequency and shortened the firing latency of PEN, while decreased the evoked firing frequency and prolonged the inhibitory duration of PIN in the hippocampal CA3 region of rat evoked by the noxious stimulation. Intra-CA3 region administration of MK-801 (0.25 μg/1 μl) produced the opposite response. These results suggest that Glu and its receptors in hippocampal CA3 region are involved in the modulation of nociceptive information transmission by affecting the electric activities of PENs and PINs.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Ma X,Shi TF,Zhang M,Lu XY,Yang CX,Zhu D,Shi DX,Yang Y,Wang CL,Zhang S,Xu MYdoi
10.1016/j.neulet.2012.02.009subject
Has Abstractpub_date
2012-03-28 00:00:00pages
67-71issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(12)00180-2journal_volume
513pub_type
杂志文章abstract::Comparable to the anti-craving compound acamprosate, caroverine reduces alcohol withdrawal symptoms by an antagonism at ionotropic glutamate receptors and a blockade of calcium channels. The present study examines the effect of caroverine in a craving model, in which acamprosate has proved effective before. A place av...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(03)00783-3
更新日期:2003-10-02 00:00:00
abstract::The cells of the entorhinal cortex receive a dense innervation of serotonergic fibres from the Raphe nuclei and express a high density of 5-hydroxytryptamine 1A (5-HT1A) receptors. We investigated the effects of serotonin on excitatory synaptic transmission in principal cells from entorhinal cortex layers II and III w...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(95)11494-h
更新日期:1995-04-28 00:00:00
abstract::A mini-symposium (chaired by L. Chal, Australia, P. Lembeck, Austria, J. Szolcsányi, Hungary and M. Zimmermann, F.R.G.) was held in Bad Nauheim, F.R.G. on June 29, 1990, under the sponsorship of the European Neuropeptide Club, which focussed on recent advances of research on sensory peptides and mechanism of action of...
journal_title:Neuroscience letters
pub_type: 杂志文章,评审
doi:10.1016/0304-3940(91)90857-p
更新日期:1991-01-28 00:00:00
abstract::The interaction of NMDA receptor (NMDAR) activation and other mechanisms regulating neuronal excitability have not been thoroughly described. While excess activation of NMDARs results in excitotoxicity, partial activation of NMDARs by d-cycloserine (DCS) is nootropic, enhancing both acquisition and extinction of memor...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2014.04.035
更新日期:2014-06-13 00:00:00
abstract::We studied event-related desynchronization (ERD) of the 8-13 Hz rhythm (mu rhythm) of the primary somatosensory cortex (SI) caused by contra- and ipsilateral median-nerve stimulation. We used whole-head magnetoencephalography (MEG) and wavelet analysis together with our newly developed color-coded single-trial ERD dis...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(00)01562-7
更新日期:2000-11-24 00:00:00
abstract::We have tested the hypothesis that referred pain of pelvic viscera is elicited by dichotomizing branches of unmyelinated primary afferents projecting via the pelvic nerve to the viscera and through the pudendal nerve to the perineum where pelvic pain is commonly referred to. Using neurophysiological techniques 588 unm...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(88)90281-9
更新日期:1988-11-22 00:00:00
abstract::Blood-brain barrier (BBB) is known to be structured with astroglial cells (AGs) and brain endothelial cells (BECs), and it has been proposed that these cells play different roles in the BBB. We cultivated AGs and BECs from infant rats (2-week-old), and these cells were cultured on the opposing side of collagen membran...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(96)12555-6
更新日期:1996-04-19 00:00:00
abstract::The breakdown in brain ionic homeostasis during energy deprivation (anoxic depolarization [AD]) is intimately linked to neuronal injury. We studied the role of one particular route of Na+ influx, voltage-sensitive Na+ channels, in the AD induced by O2 and/or glucose deprivation. We recorded extracellular Na+ concentra...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(99)00728-4
更新日期:1999-11-05 00:00:00
abstract::Activation of microglia is a central part of the chronic inflammatory process in Alzheimer disease (AD). The monocyte chemoattractant protein-1 (MCP-1) is a chemokine that plays a role in microglial migration and accumulation at sites of beta-amyloid deposition in senile plaques in the AD brain. A polymorphism in the ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2004.01.035
更新日期:2004-04-22 00:00:00
abstract::Tryptophan hydroxylase 2 (TPH2) is a rate-limiting enzyme of neuronal serotonin biosynthesis. Recently, two single nucleotide polymorphisms (SNPs) at the exon 11 coding region that resulted in amino acid substitutions in the C-terminal domain have been reported to affect enzyme activity in humans and mice. We determin...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2006.11.010
更新日期:2007-02-02 00:00:00
abstract::The human nervous system displays remarkable functional plasticity following long-term sensory deprivation. For example, the auditory cortex of congenitally deaf humans may start to process tactile information. To further explore this type of cross-modal plasticity, we examined the tactile accuracy of congenitally dea...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(01)01597-x
更新日期:2001-03-23 00:00:00
abstract::We are attempting to determine the neuronal factors that influence upper airway patency during sleep in the elderly. Serotonin has a facilitatory effect on hypoglossal motoneurons that innervate the tongue, and manipulations of the serotonergic system alter airway patency. We hypothesized that age-associated changes i...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(99)00337-7
更新日期:1999-05-28 00:00:00
abstract::Single-site variants in the calmodulin-binding domain of RC3/neurogranin were heterologously expressed in Xenopus oocytes to examine their effects on serotonin-evoked currents. RC3 variants serine36 -->alanine (Ser36-->Ala), serine36-->glycine (Ser36-->Gly), and phenylalanine37-->tryptophan (Phe37-->Trp), which bind c...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(96)13203-1
更新日期:1996-11-29 00:00:00
abstract::Localization of the epileptogenic zone (EZ) is an important issue in epileptology, even though there is not a unique definition of the epileptic focus. By using complex network analysis of electrocorticographic (ECoG) data we identify three singular areas in the temporal lobe of epileptic patients, the node with highe...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2008.09.080
更新日期:2008-12-12 00:00:00
abstract::Parkin gene mutations are by far the most common mutations in both familial Parkinson's disease (PD) and sporadic PD. Approximately, 50% of parkin mutations is exon dosage mutations (i.e., deletions and duplications of entire exons). Here, we first established a MLPA assay for quick detection of parkin exon rearrangem...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2015.07.046
更新日期:2015-09-14 00:00:00
abstract::Both feedforward and feedback mechanisms are used to ensure accurate movements. Feedback information comes primarily from vision and proprioception; the relative contributions of these modalities to on-line control of action and internal model maintenance remain unclear. We report data from an experiment in which a ch...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2009.01.002
更新日期:2009-02-27 00:00:00
abstract::A free radical scavenger edaravone is clinically used in Japan for acute stroke, and several basic researches have carefully examined the mechanisms of edaravone's protective effects. However, its actions on pro-inflammatory responses under stroke are still understudied. In this study, we subjected adult male Sprague-...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2016.08.048
更新日期:2016-10-28 00:00:00
abstract::The involvement of spinal glial cells in the nociceptive behaviors induced by 800 pmol of histamine was determined in mice. Histamine at 800 pmol injected intrathecally (i.t.) produced nociceptive behaviors, consisting of scratching, biting and licking. The nociceptive behaviors induced by histamine were significantly...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2011.02.038
更新日期:2011-05-16 00:00:00
abstract::The eyeblink conditioning paradigm captures an elementary form of associative learning in a neural circuitry that is understood to an extraordinary degree. Cerebellar cortical Purkinje cell simple spike suppression is widely regarded as the main process underlying conditioned responses (CRs), leading to disinhibition ...
journal_title:Neuroscience letters
pub_type: 杂志文章,评审
doi:10.1016/j.neulet.2018.04.035
更新日期:2019-01-01 00:00:00
abstract::The mammalian Period1 gene is rhythmically expressed and its proteins are found within the nucleus of the cells of the suprachiasmatic nuclei (SCN), the central circadian pacemaker in mammals; however, whether the target of the PER1 proteins is also the nucleus in the retinal peripheral clock cells is yet to be determ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2007.03.054
更新日期:2007-05-23 00:00:00
abstract::Cholinergic amacrine cells in the rabbit retina have been detected by localizing choline acetyltransferase-like immunoreactivity. The characteristic array of normally placed and displaced amacrine cells was detected, as were two major synaptic plexuses in the inner plexiform layer. At the ultrastructural level, the mo...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(87)90310-7
更新日期:1987-03-09 00:00:00
abstract::In untreated patients with Parkinson's disease (PD), the total (free and conjugated) serotonin (5-HT) and dopamine (DA) concentrations in the cerebrospinal fluid decreased significantly. While the 5-HT concentration displayed a non-significant trend of negative correlation with the DA concentration in controls, it had...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(93)90817-5
更新日期:1993-09-03 00:00:00
abstract::The aim of our experiments was to assess the effect of acutely administered corticosterone on the expression of glucocorticoid receptors (GRs) in the brain of rats with high (HR) and low (LR) levels of anxiety. The rats were divided into groups according to their conditioned fear-induced freezing responses and then we...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2012.11.012
更新日期:2013-01-15 00:00:00
abstract::An increase in the arthritis index as a marker of chronic inflammation and suppression of food intake are observed in adjuvant arthritic (AA) rats. Our previous study demonstrated that central oxytocin (OXT)-ergic pathways were activated potently in AA rats. In the present study, OXT-saporin (SAP) cytotoxin, which che...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2016.04.010
更新日期:2016-05-16 00:00:00
abstract:BACKGROUND:Gabor patterns are defined as the product of a sinusoid function and a Gaussian envelope and are commonly used in visual and attentional research due to their ability to selectively stimulate the primary visual cortex. The aim of this study was to investigate whether Gabor patterns can be used as visual stim...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2020.134970
更新日期:2020-05-29 00:00:00
abstract::Tapentadol is a dual action molecule with mu opioid agonist and norepinephrine (NE) reuptake blocking activity that has recently been introduced for the treatment of moderate to severe pain. The effects of intraperitoneal (i.p.) morphine (10mg/kg), tapentadol (10 or 30 mg/kg) or duloxetine (30 mg/kg), a norepinephrine...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2013.08.017
更新日期:2014-03-06 00:00:00
abstract::Tinnitus is the perception of sound without an external source and is known to be associated with altered neuronal excitability in the auditory system. Tinnitus severity can be assessed by various psychometric instruments and there is no objective measures developed to evaluate tinnitus severity and therapeutic effect...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2016.04.032
更新日期:2016-05-27 00:00:00
abstract::The present experiment investigated cortical responses of native Italian subjects during reading of short sentences including semantic or morphosyntactic violations. Given the specificity of the Italian language in which the sequencing of words is relatively more free than in English or other languages, we investigate...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(01)02528-9
更新日期:2002-03-29 00:00:00
abstract::Arterial pressure (AP) is known to fluctuate during parabolic-flight-induced gravitational changes in human subjects, increasing during hypergravity and decreasing during microgravity. In this study, we examined whether the vestibular system participates in the AP response to the gravitational changes induced by parab...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2011.03.052
更新日期:2011-05-16 00:00:00
abstract::Changes in von Frey hair perception, pricking pain, and vibration thresholds were examined in six healthy human adults, in the zone of secondary hyperalgesia, 45 min following the topical application of capsaicin at concentrations of 0.05 and 0.1 mg/ml. In two of these subjects, cutaneous blood flow was monitored at 1...
journal_title:Neuroscience letters
pub_type: 临床试验,杂志文章
doi:10.1016/s0304-3940(99)00248-7
更新日期:1999-04-30 00:00:00