Abstract:
:In untreated patients with Parkinson's disease (PD), the total (free and conjugated) serotonin (5-HT) and dopamine (DA) concentrations in the cerebrospinal fluid decreased significantly. While the 5-HT concentration displayed a non-significant trend of negative correlation with the DA concentration in controls, it had a significant positive correlation with the DA concentration in untreated PD patients. In L-dopa-treated patients, the DA concentration increased remarkably, whereas the 5-HT concentration decreased further compared with untreated patients. The tryptophan, 5-hydroxyindolacetic acid (5-HIAA), and 3-OH kynurenine concentrations had significant positive correlations with L-dopa doses. The 5-HT concentration had a significant positive correlation with scores of psychomatric testing in L-dopa-treated patients.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Tohgi H,Abe T,Takahashi S,Takahashi J,Hamato Hdoi
10.1016/0304-3940(93)90817-5subject
Has Abstractpub_date
1993-09-03 00:00:00pages
135-8issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(93)90817-5journal_volume
159pub_type
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