Abstract:
:Decreased expression of NT-3 mRNA in the sciatic nerve and leg muscles of streptozotocin (STZ)-diabetic rats has been associated with the pathogenesis of diabetic neuropathy. The aim of this study was to determine whether STZ-induced diabetes also affects the expression of NT-3 mRNA in the central and peripheral projections of sensory nerves. Competitive reverse transcription-polymerase chain reaction (cRT-PCR) was used to quantify the levels of NT-3 mRNA in the dorsal root, sural nerve, sciatic nerve and foot skin of age-matched and 12-week STZ-diabetic rats. Diabetes increased by 52% (P < 0.05) the expression of NT-3 mRNA in the dorsal root and sural nerve. It is proposed that diabetes-induced sensory nerve damage may elevate NT-3 mRNA production which may act as a source of neurotrophic support for sensory axons whose target-derived supply of NT-3 may be impaired.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Cai F,Tomlinson DR,Fernyhough Pdoi
10.1016/s0304-3940(99)00124-xkeywords:
subject
Has Abstractpub_date
1999-03-26 00:00:00pages
81-4issue
2-3eissn
0304-3940issn
1872-7972pii
S0304-3940(99)00124-Xjournal_volume
263pub_type
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