Elevated expression of neurotrophin-3 mRNA in sensory nerve of streptozotocin-diabetic rats.

Abstract:

:Decreased expression of NT-3 mRNA in the sciatic nerve and leg muscles of streptozotocin (STZ)-diabetic rats has been associated with the pathogenesis of diabetic neuropathy. The aim of this study was to determine whether STZ-induced diabetes also affects the expression of NT-3 mRNA in the central and peripheral projections of sensory nerves. Competitive reverse transcription-polymerase chain reaction (cRT-PCR) was used to quantify the levels of NT-3 mRNA in the dorsal root, sural nerve, sciatic nerve and foot skin of age-matched and 12-week STZ-diabetic rats. Diabetes increased by 52% (P < 0.05) the expression of NT-3 mRNA in the dorsal root and sural nerve. It is proposed that diabetes-induced sensory nerve damage may elevate NT-3 mRNA production which may act as a source of neurotrophic support for sensory axons whose target-derived supply of NT-3 may be impaired.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Cai F,Tomlinson DR,Fernyhough P

doi

10.1016/s0304-3940(99)00124-x

keywords:

subject

Has Abstract

pub_date

1999-03-26 00:00:00

pages

81-4

issue

2-3

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(99)00124-X

journal_volume

263

pub_type

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