Abstract：
:We recently described dextran derivatives (RGTA) which stimulate tissue repair in several in vivo models. One of them, RGTA11, has been shown to accelerate crush-induced regeneration and reinnervation of rat EDL and Soleus muscles. In this study we wanted to know if RGTA11 alters the pattern of myosin heavy chain expression during regeneration. In both EDL and Soleus muscles, RGTA11, injected at the moment of the crush, was found to accelerate the shift from neonatal to adult myosin heavy chain isoforms within 2 weeks. The proportion of slow fibers increased considerably, especially in the Soleus where RGTA11 induced a precocious and permanent expression of slow myosin isoform, thus confirming that a more efficient innervation had occurred in the presence of RGTA11. These results illustrate the interesting potential pharmacological use of such dextran derivatives in neuromuscular disease.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Aamiri A,Butler-Browne GS,Martelly I,Barritault D,Gautron Jdoi
10.1016/0304-3940(95)12182-xsubject
Has Abstractpub_date
1995-12-15 00:00:00pages
243-6issue
3eissn
0304-3940issn
1872-7972pii
030439409512182Xjournal_volume
201pub_type
杂志文章abstract：:Rats were treated with once-daily subcutaneous injections of atropine or normal saline for 10 days. Cryostat sections of fresh-frozen brain were subjected to quantitative muscarinic receptor ([3H]quinuclidinylbenzilate (QNB)) binding autoradiography, and quantitative in-situ hybridization autoradiography for beta-amyl...
journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：
更新日期：1996-10-18 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
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