Increased beta-amyloid precursor protein mRNA in the rat cerebral cortex and hippocampus after chronic systemic atropine treatment.

abstract：:Morphine analgesia measured by the tail withdrawal test was examined in rats that were either restrained or left free during testing. It was found that restraint potentiated morphine analgesia and decreased the latency of the peak analgesic effect. Methysergide, a serotonin antagonist, and valine, which prevents the i...

journal_title：Neuroscience letters

authors： Kelly SJ,Franklin KB

更新日期：1984-02-24 00:00:00

abstract：:The possible voltage-dependence of the dopamine transporter (DAT) was investigated using electrophysiological and electrochemical recordings in rat brain slices containing the substantia nigra (SN). Whole-cell patch clamp recordings of DA neurons, revealed that addition of 15 mM KCl rapidly depolarized the membrane po...

journal_title：Neuroscience letters

authors： Hoffman AF,Zahniser NR,Lupica CR,Gerhardt GA

更新日期：1999-01-29 00:00:00

abstract：:The regulation of blood glucose level in intracerebroventricular (i.c.v.) administration with opioid alone or opioid withdrawal model was studied in ICR mice. In the first group, we found that i.c.v. administered morphine or beta-endorphin alone causes an elevation of blood glucose level. Blood glucose level induced b...

journal_title：Neuroscience letters

authors： Park SH,Sim YB,Kang YJ,Kim SM,Lee JK,Jung JS,Suh HW

更新日期：2010-06-07 00:00:00

abstract：:There is increasing evidence that sleep may be involved in memory consolidation. However, there remain comparatively few studies that have explored the relationship between sleep and memory reconsolidation. At present study, we tested the effects of rapid eye movement sleep deprivation (RSD) on the reconsolidation of ...

journal_title：Neuroscience letters

authors： Tian S,Huang F,Li P,Ouyang X,Li Z,Deng H,Yang Y

更新日期：2009-09-29 00:00:00

abstract：:Neocortical neurofibrillary tangles (NFT) revealed by Bodian technique and anti-tau immunolabelling were seen in 5/5 cases of progressive supranuclear palsy (PSP) aged 58-76 years. These lesions differed from Alzheimer's disease or age-related changes: (1) they were most frequent in the precentral gyrus (Brodmann's ar...

journal_title：Neuroscience letters

authors： Hauw JJ,Verny M,Delaère P,Cervera P,He Y,Duyckaerts C

更新日期：1990-11-13 00:00:00

abstract：:MicroRNAs, such as miR-34, have been reported to influence age-related diseases. In this study, we explored the role of the miR-34a/Bcl-2 signaling pathway in age-related hearing loss (AHL). Using an AHL mouse model (C57BL/6), we found that the expression of miR-34a in the cochlea increased with age, whereas expressio...

journal_title：Neuroscience letters

authors： Huang Q,Zheng Y,Ou Y,Xiong H,Yang H,Zhang Z,Chen S,Ye Y

更新日期：2017-11-20 00:00:00

abstract：:Ablation of the frog's nucleus isthmi results in a visual scotoma contralateral to the lesion. Within the scotoma, animals do not respond to visually presented prey or threats. The locus of visual loss is related to the area of isthmal tissue ablated. With complete unilateral ablation, a frog displays no visually elic...

journal_title：Neuroscience letters

authors： Caine HS,Gruberg ER

更新日期：1985-03-15 00:00:00

abstract：:Seizures are relatively common in the first weeks of life and can have lasting effects on brain development due to glutamate excitotoxicity. The excitatory amino acid transporter 2 (EAAT2) is responsible for the majority of glutamate uptake in the brain and mice with this gene deleted die from seizures. Therefore, we ...

journal_title：Neuroscience letters

authors： Lauriat TL,Schmeidler J,McInnes LA

更新日期：2007-01-22 00:00:00

abstract：:Histone modifications, such as lysine methylation, acetylation and ubiquitination, are epigenetic tags that shape the chromatin landscape and regulate transcription required for synaptic plasticity and memory. Here, we show that transcription-promoting histone H3 trimethylated at lysine 4 (H3K4me3), histone H3 acetyla...

journal_title：Neuroscience letters

authors： Bach SV,Tacon PR,Morgan JW,Hegde AN

更新日期：2015-03-30 00:00:00

abstract：:A comparison has been made of the effects of carbon monoxide (CO) or nitrogen (N2) exposure on synaptic transmission in the hippocampal slice. CA1 field potentials, evoked by Schaffer collateral stimulation, were unaffected by superfusion of slices with artificial cerebral spinal fluid (ACSF) equilibrated with either ...

journal_title：Neuroscience letters

authors： Doolette DJ,Kerr DI

更新日期：1992-04-13 00:00:00

abstract：:Since the rubro-olivary projection has not been demonstrated in the rat, unlike the monkey and cat (refs. in text). HRP or highly-concentrated wheat germ agglutinin-horseradish peroxidase (WGA-HRP) was injected into the inferior olivary nucleus using a ventral approach. After processing with a modified technique, sect...

journal_title：Neuroscience letters

authors： Kennedy PR

更新日期：1987-03-09 00:00:00

abstract：:Aripiprazole, a novel atypical antipsychotic drug, can significantly increase dopamine (DA) levels in the prefrontal cortex of rats, but only at low doses below 1mg/kg. The aim of the present work was to test the effect of aripiprazole (0, 0.1, 0.3, 3 and 30 mg/kg, i.p.) on extracellular levels of monoamines in the pr...

journal_title：Neuroscience letters

authors： Zocchi A,Fabbri D,Heidbreder CA

更新日期：2005-10-28 00:00:00

abstract：:The morphology and spatial distribution of terminals emitted by corticothalamic axons originating from the rat motor cortex (as defined by intracortical microstimulations) were studied using Phaseolus vulgaris leucoagglutinin (PHA-L) as an anterograde tracer. After PHA-L injection in the face, forelimb or hindlimb mot...

journal_title：Neuroscience letters

authors： Rouiller EM,Liang FY,Moret V,Wiesendanger M

更新日期：1991-04-15 00:00:00

abstract：:This study explored whether patients with Parkinson's disease alter the regulation of upright standing according to constraints imposed by the environmental context. The provision of context-dependent adaptations was inferred from the presence of adjustments to standing postural control that would serve to reduce fall...

journal_title：Neuroscience letters

authors： Brown LA,Doan JB,Whishaw IQ,Suchowersky O

更新日期：2007-05-18 00:00:00

abstract：:Using the monoclonal antibody, ME 20.4, against the p75 nerve growth factor (NGF) receptor, NGF receptor-like immunoreactivity has been identified in axonal processes innervating the human hippocampus, where previously a loss of reactivity has been reported in a preliminary study of Alzheimer's disease [10]. In an ext...

journal_title：Neuroscience letters

authors： Kerwin JM,Morris CM,Perry RH,Perry EK

更新日期：1992-08-31 00:00:00

abstract：:The effects of bilateral cut of the stria terminalis (ST) on the dosage of estradiol benzoate (EB) needed to induce the lordosis reflex in the ovariectomized female rat were examined. Seven different doses ranging 0.5-20 micrograms were given s.c. in oil, daily for 2 days in a counterbalanced order, at 3-week interval...

journal_title：Neuroscience letters

authors： Takeo T,Kudo M,Sakuma Y

更新日期：1995-01-23 00:00:00

abstract：:The mechanisms underlying aggregate formation in age-related neurodegenerative diseases remain not well understood. Here we investigated whether dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A (Dyrk1A) is involved in the formation of regulator of calcineurin 1 (RCAN1) aggregates. We show that RCAN1 s...

journal_title：Neuroscience letters

authors： Song WJ,Song EA,Choi SH,Baik HH,Jin BK,Kim JH,Chung SH

更新日期：2013-10-25 00:00:00

abstract：:We investigated the effects of a representative anti-epileptic or anti-psychotic drug, carbamazepine (CBZ), on the induction of long-term potentiation (LTP) in the perforant path-dentate gyrus pathway in 15 chronically prepared rabbits. Pharmacokinetically injected low-dose CBZ, which produced steady serum levels of 2...

journal_title：Neuroscience letters

authors： Kubota T,Jibiki I,Fukushima T,Kurokawa K,Yamaguchi N

更新日期：1994-03-28 00:00:00

abstract：:Superoxide dismutase 1 (SOD1) aggregates are a histological and biochemical correlate of disease progression in neural tissues from mutant SOD1-linked forms of familial amyotrophic lateral sclerosis (FALS). In the present study, we assayed the monomeric and high molecular weight mutant SOD1 content of nervous, muscle ...

journal_title：Neuroscience letters

authors： Turner BJ,Lopes EC,Cheema SS

更新日期：2003-10-23 00:00:00

abstract：:Plasma corticosterone has been correlated with the susceptibility to animal hypnosis in male rabbits. Subjects (Ss) were considered susceptible when mean hypnosis duration was above 30 sec or when initial duration (duration of trial 1) was greater than 0. A positive significant correlation was found between mean and i...

journal_title：Neuroscience letters

authors： Carli G,Farabollini F,di Prisco CL

更新日期：1979-03-01 00:00:00

abstract：:Damaged axons in the adult central nervous system (CNS) fail to regenerate spontaneously due to several intrinsic and extrinsic factors that inhibit axon elongation. An extrinsic inhibitory factor, repulsive guidance molecule-a (RGMa), is upregulated around spinal cord lesion sites. Inhibition of RGMa using an antibod...

journal_title：Neuroscience letters

authors： Nakanishi T,Fujita Y,Tanaka T,Yamashita T

更新日期：2019-09-14 00:00:00

abstract：:The purpose of this investigation was to evaluate the effect and mechanisms of electroacupuncture (EA) at the bilateral Zusanli acupoints (ST-36) on glucose tolerance in normal rats. Intravenous glucose tolerance test (IVGTT) was performed to examine the effects of electroacupuncture (EA) on glucose tolerance in rats....

journal_title：Neuroscience letters

authors： Lin RT,Chen CY,Tzeng CY,Lee YC,Cheng YW,Chen YI,Ho WJ,Cheng JT,Lin JG,Chang SL

更新日期：2011-04-25 00:00:00

abstract：:The role of oropharyngeal mechanisms in body water regulation was studied in 12 human males by measuring urine output and osmolality before and after drinking a very small volume of distilled water (0.15 ml/kg b.w.t.). Hypotonic diuresis was resulted only in the subjects (n = 6) who drank only sufficient water to keep...

journal_title：Neuroscience letters

authors： Akaishi T,Shingai T,Miyaoka Y,Homma S

更新日期：1989-12-15 00:00:00

abstract：:Bay K 8644, nimodipine and omega-conotoxin GVIA (omega-CgTx) were used to study the different contribution of voltage-sensitive calcium channels (VSCC) to [3H]acetylcholine ([[3H]ACh) release in rat hippocampal synaptosomes. In our experimental conditions, the percentage of calcium-dependent ACh release was approximat...

journal_title：Neuroscience letters

authors： Clos MV,Garcia Sanz A,Sabriá J,Pastor C,Badia A

更新日期：1994-12-05 00:00:00

abstract：:Previous studies showed that adenosine receptors of the temporal and frontal cortices were not affected in Alzheimer's disease (AD). Here, we assessed the specific binding of [3H]cyclohexyladenosine to adenosine1 (A1) receptors in hippocampus from AD subjects and age-matched controls. By both particulate membrane and ...

journal_title：Neuroscience letters

authors： Kalaria RN,Sromek S,Wilcox BJ,Unnerstall JR

更新日期：1990-10-16 00:00:00

abstract：:The calcitonin-gene receptor peptide (alphaCGRP) receptor is present in high levels in the caudal striatum of the rat. Previous behavioural experiments have highlighted a possible correlation between alphaCGRP-mediated effects and the dopaminergic system. In this study, we examined the effect of alphaCGRP on K(+)-evok...

journal_title：Neuroscience letters

authors： Maneuf YP,McKnight AT

更新日期：2001-09-14 00:00:00

abstract：:Stroke in rodents is associated with increased neurogenesis and the migration of newborn neurons to sites of brain ischemia, where they may participate in repair and recovery. To determine if neurogenesis following stroke yields functional new neurons, we labeled neuronal precursors in the mouse subventricular zone (S...

journal_title：Neuroscience letters

authors： Lai B,Mao XO,Xie L,Jin K,Greenberg DA

更新日期：2008-09-19 00:00:00

abstract：:The contribution of excitatory inputs to CA1 pyramidal cell death after ischemia was examined using rats with unilateral destruction of CA3 pyramidal cells. Intracerebroventricular injection of L-alpha-kainic acid (KA) was performed before the induction of transient forebrain ischemia. Five days after ischemic insult,...

journal_title：Neuroscience letters

authors： Onodera H,Sato G,Kogure K

更新日期：1986-07-24 00:00:00

abstract：:Two electrophysiologically distinct cell types were found with intracellular recordings for the first time in an in vitro preparation of the olfactory epithelium of the salamander, Ambystoma tigrinum. Intracellular recordings showed that Type I cells did not discharge action potentials but had high resting membrane po...

journal_title：Neuroscience letters

authors： Masukawa LM,Kauer JS,Shepherd GM

更新日期：1983-01-31 00:00:00

abstract：:The contribution of retinal and extraretinal signals to the coding of eye position in the head was studied in human subjects (Ss). Horizontal saccades were produced in darkness. For some trials, before returning gaze direction to the starting position, a visual signal briefly stimulated the foveal retina. Results show...

journal_title：Neuroscience letters

authors： Blouin J,Gauthier GM,Vercher JL

更新日期：1995-01-09 00:00:00