Abstract：
:This study explored whether patients with Parkinson's disease alter the regulation of upright standing according to constraints imposed by the environmental context. The provision of context-dependent adaptations was inferred from the presence of adjustments to standing postural control that would serve to reduce fall risk when balance was challenged by a threatening environmental context. Participants were asked to stand as still as possible in two environmental context conditions that differed in the level of imposed postural threat: LOW threat and HIGH threat. Eight levodopa dependent patients with Parkinson's disease (PD) and eight age-matched control subjects (CTRL) provided the subject sample. PD patients were tested following a 12-h withdrawal of anti-Parkinsonian medications and approximately 1h post-medication. The CTRL group showed altered postural control in the HIGH threat condition, in a manner that was indicative of appropriate context-dependent regulation of standing. PD patients, in the non-medicated or medicated states, did not modify stance regulation when the environmental context heightened postural threat. Our results extend the current understanding of Parkinsonian deficits in the context-dependent regulation of postural control to include upright standing.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Brown LA,Doan JB,Whishaw IQ,Suchowersky Odoi
10.1016/j.neulet.2007.03.040subject
Has Abstractpub_date
2007-05-18 00:00:00pages
292-7issue
3eissn
0304-3940issn
1872-7972pii
S0304-3940(07)00348-5journal_volume
418pub_type
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