Abstract：
:In order to characterise primary central nervous system lymphomas (PCNSL) and to evaluate if 1H spectroscopy improves the preoperative differential diagnosis of PCNSL and glioma, seven immunocompetent patients with PCNSL and 21 patients with glioma were examined using single voxel, short echo time magnetic resonance spectroscopy (MRS; 1.5 T, STEAM 1500/20). All PCNSL demonstrated massively elevated lipid resonances and markedly elevated choline. Similarly increased lipid resonances were only found in seven necrotic glioblastomas, PCNSL differing from all solid astrocytomas by massively elevated lipid resonances. Additionally, PCNSL had higher Cho/Cr ratios than all grades of astrocytoma. In conclusion, we found that massively elevated lipid resonances are a hallmark of PCNSL in immunocompetent patients. Together with a markedly elevated Cho/Cr ratio, MRS provides metabolic information which may improve the preoperative differentiation of PCNSL and glioma.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Harting I,Hartmann M,Jost G,Sommer C,Ahmadi R,Heiland S,Sartor Kdoi
10.1016/s0304-3940(03)00272-6keywords:
subject
Has Abstractpub_date
2003-05-22 00:00:00pages
163-6issue
3eissn
0304-3940issn
1872-7972pii
S0304394003002726journal_volume
342pub_type
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