The effect of somatostatin on striatal catecholamines.

Abstract:

:Somatostatin and several analogues were injected into rat striatum and their effects on dopamine, serotonin and their metabolites were examined at 1 h. Somatostatin induced a dose-dependent increase in dopamine turnover in the ipsilateral striatum accompanied by a reduction in turnover on the contralateral side. There was no effect on serotonin turnover. Long-acting somatostatin analogues (D-Trp-8-somatostatin, SMS-201-995) had similar effects. These results suggest that somatostatin is involved in local regulation of striatal dopaminergic transmission and that it plays a role in regulation of dopamine release in the contralateral striatum.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Beal MF,Martin JB

doi

10.1016/0304-3940(84)90034-x

subject

Has Abstract

pub_date

1984-02-24 00:00:00

pages

271-6

issue

3

eissn

0304-3940

issn

1872-7972

pii

0304-3940(84)90034-X

journal_volume

44

pub_type

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