Abstract:
:The permeation of 36Cl from blood into choroid plexus (CP) and cerebrospinal fluid (CSF) was studied in adult rats intraventricularly injected with either dibutyryl (db)-cAMP, theophylline with db-cAMP, or forskolin. All 3 treatments significantly enhanced the 15-min distribution (Vd) of 36Cl into CSF, by an average of 17-33%. In contrast, ouabain and acetazolamide (inhibitors of CSF production) reduced 36Cl uptake into CSF by 34% and 13%, respectively. A correlative analysis of the various treatments revealed that the volume of distribution of 36Cl in CSF varied inversely with that in the choroid plexus. This inverse relationship suggests drug effects on Cl movement across the apical (CSF-facing) membrane of CP.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Deng QS,Johanson CEdoi
10.1016/0304-3940(92)90253-4keywords:
subject
Has Abstractpub_date
1992-08-31 00:00:00pages
146-50issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(92)90253-4journal_volume
143pub_type
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