当前位置： SCI文献检索 > NEUROSCIENCE LETTERS期刊下所有文献 > Regional and subcellular distribution of GABAC ρ3 receptor in brain of R6/2 mouse model of Huntington's disease.

Regional and subcellular distribution of GABAC ρ3 receptor in brain of R6/2 mouse model of Huntington's disease.

Abstract：

:In the present study, we describe the distribution of GABAC ρ3 receptor immunoreactivity in the cortex, striatum and hippocampus of wild type (wt) and 11 weeks old HD transgenic (tg) R6/2 mouse brain. In the brain of wt mice, GABAC ρ3 immunoreactivity is well expressed in neuronal cells, nerve fibers and axonal processes. In comparison to wt, GABAC ρ3 receptor like immunoreactivity decreases significantly in all three brain regions of R6/2 mice. The altered distributional pattern and significant changes in GABAC ρ3 receptor immunoreactivity as seen in the R6/2 mouse brain might be a plausible molecular mechanism for excitotoxicity in HD pathogenesis due to the loss of inhibitory input.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Kumar U,Heer M,Somvanshi RK

doi

10.1016/j.neulet.2017.01.035

subject

Has Abstract

pub_date

2017-02-15 00:00:00

pages

81-87

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(17)30045-9

journal_volume

640

pub_type

杂志文章

相关文献

NEUROSCIENCE LETTERS文献大全
  • Independent occurrence of I2020T mutation in the kinase domain of the leucine rich repeat kinase 2 gene in Japanese and German Parkinson's disease families.

    abstract：:To understand the genetic origin of I2020T mutation in the kinase domain of leucine rich repeat kinase 2 (LRRK2), we investigated the original PARK8 Japanese family (Sagamihara family) and a German family (family 32), both of which were found to harbor I2020T as the causal mutation for autosomal dominant familial Park...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2007.02.086

    authors： Ohta E,Hasegawa K,Gasser T,Obata F

    更新日期：2007-04-24 00:00:00

  • Association between the alpha-2C-adrenergic receptor gene and attention deficit hyperactivity disorder in a Korean sample.

    abstract：:Findings from preclinical and clinical research support the involvement of central noradrenergic dysregulation in the etiology of attention deficit hyperactivity disorder (ADHD). Previous studies have suggested that the alpha-2C-adrenergic receptor gene (ADRA2C) is associated with ADHD. The aims of this study were to ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2008.09.058

    authors： Cho SC,Kim JW,Kim BN,Hwang JW,Shin MS,Park M,Kim SA,Cho DY,Yoo HJ,Chung US,Son JW,Park TW

    更新日期：2008-12-03 00:00:00

  • Effects of different unstable supports on EMG activity and balance.

    abstract：:This study analysed the equilibrium strategies and EMG activity during postural equilibrium in four different unstable surfaces. Thirteen team sport males were tested on a FLAT surface and on three different wobble boards (JAKOBS(®) with easy multidirectional displacements, FREEMAN with strong multidirectional displac...

    journal_title：Neuroscience letters

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.neulet.2013.05.025

    authors： Cimadoro G,Paizis C,Alberti G,Babault N

    更新日期：2013-08-26 00:00:00

  • Lower limb flexor reflex: Comparisons between drug-induced akathisia and restless legs syndrome.

    abstract：BACKGROUND AND OBJECTIVE:Akathisia is characterized by restlessness and crawling sensations similar to restless legs syndrome (RLS). Long latency flexor reflex (LLFR) which has helped to advance RLS pathophysiology has never been investigated in akathisia. Due to the clinical commonalities of akathisia and RLS, we inve...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2017.01.042

    authors： Gunduz A,Metin B,Metin SZ,Poyraz BC,Karadeniz D,Kiziltan G,Kiziltan ME

    更新日期：2017-02-22 00:00:00

  • Effects of acetylcholine antagonist injection into the prefrontal cortex on the progress of lever-press extinction in rats.

    abstract：:To determine the relationship between cholinergic modulation within the rat medial prefrontal cortex (mPFC) and the progress of lever-press extinction, we conducted an experiment in which muscarinic and nicotinic acetylcholine (ACh) receptor antagonists were microinjected into the mPFC. The muscarinic antagonist injec...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2003.07.012

    authors： Maruki K,Izaki Y,Akema T,Nomura M

    更新日期：2003-11-13 00:00:00

  • Projection of tooth pulp afferents to the brainstem and to the cortex in the cat.

    abstract：:The projection of tooth pulp afferents in the spinal trigeminal nucleus (N.V.sp.) and the effect of dorsolateral medullotomy on cortical potentials evoked by electrical stimulation of Adelta tooth pulp nerve fibres were studied in cats. It was confirmed that antidromic responses were recorded in the tooth pulp nerve t...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(81)90397-9

    authors： Keller O,Kalina M,Ujec E,Zivný A,Vyklický L

    更新日期：1981-09-25 00:00:00

  • Tactile perception of the roughness of the end of a tool: what role does tool handle roughness play?

    abstract：:We investigated whether the perceived roughness of the end of a tool is influenced by the texture of the handle used to hold it. Participants rated the roughness of the ends (caps) of a series of tools by rubbing them along their forearm, and indicated the perceived roughness of the tool's cap by means of an anchored ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2006.02.068

    authors： Zampini M,Mawhinney S,Spence C

    更新日期：2006-06-12 00:00:00

  • Dorsal raphé nucleus glucocorticoid receptors inhibit tph2 gene expression in male C57BL/6J mice.

    abstract：:The serotonergic dorsal raphé nucleus (DRN) expresses glucocorticoid receptors (GR), and systemic glucocorticoids have been shown to regulate expression and activity of tryptophan hydroxylase isoform 2, the rate-limiting enzyme for serotonin synthesis in brain. We have used intra-DRN injection of pseudotyped adeno-ass...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2017.11.041

    authors： Vincent MY,Donner NC,Smith DG,Lowry CA,Jacobson L

    更新日期：2018-02-05 00:00:00

  • Tangential synaptic distribution of NMDA and AMPA receptors in rat neocortex.

    abstract：:We performed an electron microscopic study in layers II-III of S-1 in rats, using postembedding immunogold histochemistry to compare the synaptic distribution of N-methyl D-aspartate (NMDA) receptors (assessed with an antibody for the NMDAR1 subunit) with that of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (A...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(97)00846-x

    authors： Kharazia VN,Weinberg RJ

    更新日期：1997-11-28 00:00:00

  • Association of polymorphisms in the melanocortin receptor type 2 (MC2R, ACTH receptor) gene with heroin addiction.

    abstract：:The melanocortin receptor type 2 (MC2R or adrenocorticotropic hormone, ACTH receptor) gene (MC2R) encodes a protein involved in regulation of adrenal cortisol secretion, important in the physiological response to stressors. A variant of MC2R, -179A>G, results in reduction of promoter activity and less adrenal action. ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2008.02.042

    authors： Proudnikov D,Hamon S,Ott J,Kreek MJ

    更新日期：2008-04-25 00:00:00

  • Subacute hemorrhage and resolution of edema in Rose Bengal stroke model in rats coincides with improved sensorimotor functions.

    abstract：:The Rose Bengal model in rats is widely used to study brain plasticity, functional recovery and restorative therapies. The present study evaluated temporal profiles of hemorrhage and edema by magnetic resonance imaging (MRI) in rats in relation to sensorimotor impairment after photochemically induced cortical infarct....

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2007.09.043

    authors： Jolkkonen J,Jokivarsi K,Laitinen T,Gröhn O

    更新日期：2007-11-27 00:00:00

  • Anterior cingulate GABA levels predict whole-brain cerebral blood flow.

    abstract：:This study examined the relationship of γ-aminobutyric acid (GABA) and glutamate levels from the anterior and posterior cingulates (AC and PC) with cerebral blood flow (CBF) at rest. (1)H magnetic resonance spectroscopy measurements in the AC and PC and pseudo-continuous arterial spin labeling data were acquired from ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2013.12.062

    authors： Krause BW,Wijtenburg SA,Holcomb HH,Kochunov P,Wang DJ,Hong LE,Rowland LM

    更新日期：2014-02-21 00:00:00

  • Determination of the pharmacokinetics of 2-amino-7-phosphonoheptanoate in rat plasma and cerebrospinal fluid.

    abstract：:The pharmacokinetics of 2-amino-7-phosphonoheptanoate (AP7) in rat plasma and appearance in cerebrospinal fluid (CSF) are reported. Using high-performance liquid chromatography (HPLC) with fluorescence detection, concentrations of AP7 can be detected as low as 1.0 microM. Peak CSF concentrations (12-15 microM) for bot...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(88)90532-0

    authors： Compton RP,Hood WF,Monahan JB

    更新日期：1988-02-03 00:00:00

  • The role of Bax-inhibiting peptide in retinal ganglion cell apoptosis after optic nerve transection.

    abstract：:Bax, a pro-apoptotic member of Bcl-2 family proteins, plays a central role in mitochondria-dependent apoptosis. Bax normally resides in the cytosol in a quiescent state. Bax-inhibiting peptide (BIP) is a membrane permeable peptide comprised of five amino acids designed from the Bax-binding domain of Ku70 [M. Sawada, P...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2004.08.075

    authors： Qin Q,Patil K,Sharma SC

    更新日期：2004-11-30 00:00:00

  • Involvement of central cholinergic mechanisms on sodium intake induced by gabaergic activation of the lateral parabrachial nucleus.

    abstract：:Bilateral injections of the GABA(A) agonist muscimol into the lateral parabrachial nucleus (LPBN) disrupt satiety and induce strong ingestion of water and 0.3M NaCl in fluid-replete rats by mechanisms not completely clear. In the present study, we investigated the effects of the blockade of central muscarinic choliner...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2012.11.042

    authors： Asnar DS,Roncari CF,De Luca LA Jr,de Paula PM,Colombari DS,Menani JV

    更新日期：2013-02-08 00:00:00

  • Myelin oligodendrocyte glycoprotein is expressed in the peripheral nervous system of rodents and primates.

    abstract：:The myelin oligodendrocyte glycoprotein (MOG) is a minor CNS myelin-specific protein that is an important candidate autoantigen in multiple sclerosis. We now report that MOG mRNA transcripts are present in the peripheral nervous system of rodents and primates at levels approximately ten-fold lower than in brain as dem...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(03)00899-1

    authors： Pagany M,Jagodic M,Schubart A,Pham-Dinh D,Bachelin C,Baron van Evercooren A,Lachapelle F,Olsson T,Linington C

    更新日期：2003-10-30 00:00:00

  • Dual immunofluorescence study of citrullinated proteins in Alzheimer diseased frontal cortex.

    abstract：:Deimination is a post-translational modification of proteins in which selected arginine amino acids are enzymatically converted to citrullines. Using dual-color immunofluorescence, the present study is the first to examine the frontal cortex of patients with Alzheimer's disease (AD) versus age-matched controls with an...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2013.04.028

    authors： Nicholas AP

    更新日期：2013-06-17 00:00:00

  • Association between the C957T polymorphism of the dopamine D2 receptor gene and schizophrenia.

    abstract：:The aim of this study was to investigate the relationship between the functional C957T single-nucleotide polymorphism of the dopamine D2 receptor (DRD2) gene and the risk for schizophrenia. We therefore conducted a case-control association study of 188 Finnish schizophrenia patients meeting the DSM-IV criteria and 384...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2006.08.041

    authors： Hänninen K,Katila H,Kampman O,Anttila S,Illi A,Rontu R,Mattila KM,Hietala J,Hurme M,Leinonen E,Lehtimäki T

    更新日期：2006-10-30 00:00:00

  • The effects of chronic copper exposure on the amyloid protein metabolisim associated genes' expression in chronic cerebral hypoperfused rats.

    abstract：:The pathogens of Alzheimer's disease (AD) are still unclear, while accumulating evidences have indicated that both genetic and environmental factors are involved in the pathogenesis of AD. Recent studies suggest that AD is primarily a vascular disorder and copper (Cu) may play an important role in AD pathology. Howeve...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2012.04.030

    authors： Mao X,Ye J,Zhou S,Pi R,Dou J,Zang L,Chen X,Chao X,Li W,Liu M,Liu P

    更新日期：2012-06-14 00:00:00

  • Neonatal enucleation during a critical period reduces the precision of cortico-cortical projections in visual cortex.

    abstract：:Previous studies have reported that intrahemispheric connections between area 17 (V1, striate cortex) and other cortical visual areas are not point-to-point, but instead have some degree of convergence and divergence. Many pathological conditions can interfere with the normal development of patterns of cortico-cortica...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2011.07.005

    authors： Bock AS,Olavarria JF

    更新日期：2011-09-01 00:00:00

  • Redox sites of NMDA receptors can modulate epileptiform activity in hippocampal slices from kainic acid-treated rats.

    abstract：:Using an animal model of temporal lobe epilepsy, the kainic acid lesioned rat hippocampus, we have evaluated the possibility of modulating glutamate N-methyl-D-aspartate (NMDA) receptor-dependent evoked epileptiform activity through the manipulation of NMDA receptor redox sites. Epileptiform activity was recorded extr...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(96)12803-2

    authors： Quesada O,Hirsch J,Ben-Ari Y,Bernard C

    更新日期：1996-07-19 00:00:00

  • 5-HT2A-mu opioid receptor mechanisms in the hypothalamus mediate interleukin-1beta fever in rats.

    abstract：:Direct administration of interleukin-1beta (IL-1beta) into the lateral cerebral ventricle of rat brain, in addition to inducing febrile responses, upregulated the immunoreactivity of tryptophan hydroxylase in the preoptic anterior hypothalamus. The fever induced by IL-1beta was significantly attenuated by pretreatment...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2005.01.074

    authors： Chio CC,Tsai SM,Wang JJ,Lin MT

    更新日期：2005-06-10 00:00:00

  • Expression of ciliary neurotrophic factor (CNTF), CNTF receptor alpha (CNTFR-alpha) following experimental intracerebral hemorrhage in rats.

    abstract：:Ciliary neurotrophic factor (CNTF) is known as a neuro-survival factor in the developing and developed CNS, as well as in the CNS following injury. However, little is known about the expression of CNTF or that of its receptor (CNTFR-alpha) in cases of intracerebral hemorrhage (ICH). We investigated the temporal and sp...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2004.11.093

    authors： Yokota H,Yoshikawa M,Hirabayashi H,Nakase H,Uranishi R,Nishimura F,Sugie Y,Ishizaka S,Sakaki T

    更新日期：2005-04-04 00:00:00

  • Exposure to a high-fat high-sugar diet causes strong up-regulation of proopiomelanocortin and differentially affects dopamine D1 and D2 receptor gene expression in the brainstem of rats.

    abstract：:A strong link between obesity and dopamine (DA) has been established by studies associating body weight status to variants of genes related to DA signalling. Human and animal studies investigating this relationship have so far focused mainly on the role of DA within the mesolimbic pathway. The aim of this study was to...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2013.11.008

    authors： Alsiö J,Rask-Andersen M,Chavan RA,Olszewski PK,Levine AS,Fredriksson R,Schiöth HB

    更新日期：2014-01-24 00:00:00

  • The therapeutic potential of human umbilical cord blood-derived mesenchymal stem cells in Alzheimer's disease.

    abstract：:The neuropathological hallmarks of Alzheimer's disease (AD) include the presence of extracellular amyloid-beta peptide (Abeta) in the form of amyloid plaques in the brain parenchyma and neuronal loss. The mechanism associated with neuronal death by amyloid plaques is unclear but oxidative stress and glial activation h...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2010.06.045

    authors： Lee HJ,Lee JK,Lee H,Shin JW,Carter JE,Sakamoto T,Jin HK,Bae JS

    更新日期：2010-08-30 00:00:00

  • Topographical distribution of pinprick and warmth thresholds to CO2 laser stimulation on the human skin.

    abstract：:We studied the topographical distribution of laser sensory thresholds on the human hairy skin, using a small laser beam for pinprick and a large beam for warmth sensations. The threshold for pinprick sensation correlated positively with the distance from the brain, suggesting that Adelta nociceptors, the fibers which ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(00)01038-7

    authors： Agostino R,Cruccu G,Iannetti G,Romaniello A,Truini A,Manfredi M

    更新日期：2000-05-12 00:00:00

  • Expression of c-Fos-like immunoreactivity in the brain of mice with learned helplessness.

    abstract：:The learned helplessness (LH) developed after repeat inescapable stress is a well validated animal model of human major depression and is not species specific. c-Fos, the protein product of the protooncogene c-fos, is expressed in neurons under a variety of stressors and could reflect the regional neuronal activation....

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2004.04.011

    authors： Huang YH,Cheng CY,Hong CJ,Tsai SJ

    更新日期：2004-06-17 00:00:00

  • Glial cell line-derived neurotrophic factor does not enter normal mouse brain.

    abstract：:Glial cell line-derived neurotrophic factor (GDNF) is produced both in the central nervous system (CNS) and the periphery. Effective in ameliorating neurodegeneration in several animal models of CNS disease, its promise as a therapeutic agent would be greatly enhanced if it readily crossed the blood-brain barrier (BBB...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(03)00007-7

    authors： Kastin AJ,Akerstrom V,Pan W

    更新日期：2003-04-17 00:00:00

  • Effects of stimulation of the frontal cortex on identified output VMT cells in the rat.

    abstract：:The neurons located in the mesencephalic ventro-medial tegmentum (VMT) and projecting to the nucleus accumbens, the septum and the frontal cortex were identified by the antidromic activation method. The activity of single VMT cells was extracellularly recorded in Ketamine anaesthetized rats. The effect of the stimulat...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(79)96097-x

    authors： Thierry AM,Deniau JM,Feger J

    更新日期：1979-12-01 00:00:00

  • Isoflurane anesthesia results in reversible ultrastructure and occludin tight junction protein expression changes in hippocampal blood-brain barrier in aged rats.

    abstract：:The underlying mechanism of isoflurane-induced cognitive dysfunction in older individuals is unknown. In this study, the effects of isoflurane exposure on the hippocampal blood-brain barrier (BBB) in aged rats were investigated because it was previously shown that BBB disruption involves in cognitive dysfunction. Twen...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2014.12.018

    authors： Cao Y,Ni C,Li Z,Li L,Liu Y,Wang C,Zhong Y,Cui D,Guo X

    更新日期：2015-02-05 00:00:00