Abstract：
:Deimination is a post-translational modification of proteins in which selected arginine amino acids are enzymatically converted to citrullines. Using dual-color immunofluorescence, the present study is the first to examine the frontal cortex of patients with Alzheimer's disease (AD) versus age-matched controls with an established monoclonal antibody (F95) against peptidyl-citrulline moieties. In AD specimens, a number of new findings were discovered, including evidence for deiminated proteins in extracellular plaques, the walls of large blood vessels, the nuclei of selective neurons immunoreactive for phosphorylated tau and numerous reactive astrocytes concentrated around extracellular plaques, ventricular surfaces and at the interface between the gray and white matter of the cortex. Although the identities of these citrullinated proteins remain largely unknown, the present study adds to the growing number of locations in which deiminated proteins may be found in the brains of patients with AD.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Nicholas APdoi
10.1016/j.neulet.2013.04.028subject
Has Abstractpub_date
2013-06-17 00:00:00pages
107-11eissn
0304-3940issn
1872-7972pii
S0304-3940(13)00377-7journal_volume
545pub_type
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