Abstract:
:In order to search for compounds mimicking the neurotrophic activities, a series of substances possessing the guanidine group of isaxonine (2-isopropylamino-pyrimidine), were synthesized and tested for their ability to induce neurite outgrowth in cultures of explants of rat dorsal root ganglia. It is reported that several of these compounds, at concentrations ranging from 10(-5) to 10(-7) M, showed important effects on neurite outgrowth in vitro, similar to that obtained with the nerve growth factor NGF. These effects were found to be additive to that of NGF.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Lehmann S,Quirosa-Guillou C,Becherer U,Thal C,Zanetta JPdoi
10.1016/0304-3940(93)90482-zsubject
Has Abstractpub_date
1993-04-02 00:00:00pages
57-60issue
1-2eissn
0304-3940issn
1872-7972pii
0304-3940(93)90482-Zjournal_volume
152pub_type
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