Abstract:
:The survival of identified retinal ganglion cells (RGGs) in vitro increased when they were plated over subcultured monolayers of astrocytes. Immunofluorescence labelling of these monolayers showed that over 85% of the cells were glial fibrillary acidic protein (GFAP) positive and consisted of large, flat immature astrocytes. Less than 7% of the total cell population in the monolayers were fibroblasts, leptomeningeal or endothelial cells. Coculturing of RGCs with subcultured astrocytes revealed that the trophic interaction between astrocytes and RGCs is mediated through cell contact.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
McCaffery CA,Raju TR,Bennett MRdoi
10.1016/0304-3940(85)90512-9subject
Has Abstractpub_date
1985-06-24 00:00:00pages
319-24issue
3eissn
0304-3940issn
1872-7972pii
0304-3940(85)90512-9journal_volume
57pub_type
杂志文章abstract::Iron mediated oxidative stress is known to contribute to the neurodegenerative process in Parkinson's disease (PD). Although there are hints that genes involved in brain iron metabolism might be involved in the pathogenesis of PD in some instances, it is still not known whether the increase in brain iron content const...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2006.07.070
更新日期:2006-10-16 00:00:00
abstract::Mutations in DJ-1 cause familial Parkinson's disease (PD). The expression pattern of DJ-1 in the brain remains controversial. In the present study, we used DJ-1 deficient mice as negative controls and examined DJ-1 mRNA expression in mouse brains. In sequential double labeling on the same sections, in situ hybridizati...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2009.09.024
更新日期:2009-11-20 00:00:00
abstract::Hearing impairment affects 1 in 500 newborns worldwide and nearly one out of three people over the age of 65 (WHO, 2019). Hereditary hearing loss is the most common type of congenital deafness; genetic factors also affect deafness susceptibility. Gene therapies may preserve or restore natural sound perception, and hav...
journal_title:Neuroscience letters
pub_type: 杂志文章,评审
doi:10.1016/j.neulet.2019.134326
更新日期:2019-09-14 00:00:00
abstract::We investigated the relation between visual feedback and the degree of structure versus randomness in the variability of single-digit, isometric force output. Participants were instructed to maintain a constant level of force during the presence or absence of visual feedback about force output. The structure of force ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2012.02.002
更新日期:2012-03-28 00:00:00
abstract::The conductance increase induced by bath application of GABA has been measured in voltage-clamped stretch-receptor neurones of crayfish. A rapid conductance increase was obtained only at GABA concentrations above 3.3 X 10(-4) M. The response to lower GABA concentrations (between 10(-4) and 10(-6) M) developed slowly o...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(84)90521-4
更新日期:1984-06-29 00:00:00
abstract::The activity of single units in the striatum of urethane-anesthetized rats was recorded before and after the systemic administration of 7-nitro-indazole (7-NI; 50 mg/kg intraperitoneally), a selective inhibitor of neuronal nitric oxide (NO) synthase. Two neuronal types were clearly distinguishable electrophysiological...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(02)00270-7
更新日期:2002-06-14 00:00:00
abstract::The effects of acute and subacute supramaximal and submaximal electroshock-induced convulsions on rat brain tribulin activity were investigated. Both supramaximal and submaximal shocks induced a marked increase, as measured 30 min after the onset of convulsions, with a significantly greater effect from the former. The...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(91)90132-d
更新日期:1991-04-15 00:00:00
abstract::In this study, we have developed a microarray including 1467 cDNAs that were selected to specifically measure stress response in peripheral blood leukocytes. Venous blood was collected from 10 graduate students 2 h before and 2 or 24 h after an open presentation for their Ph.D. The mRNA levels in leukocytes were compa...
journal_title:Neuroscience letters
pub_type: 临床试验,杂志文章
doi:10.1016/j.neulet.2005.01.081
更新日期:2005-06-10 00:00:00
abstract::Bilaterally symmetrical periventricular lesions at preoptic-anterior hypothalamic levels of anteroventral third ventricle (AV3V) produce adipsia without aphagia in the rat. Sweet palatable fluids, but not water, are drunk during the adipsic period and if hydration is thus maintained, voluntary ingestion of plain water...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(77)90043-x
更新日期:1977-07-01 00:00:00
abstract::Effects of anxiety on perceptual-motor organisation of rhythmical forearm movements were examined using an interrupted time series design with staggered baselines. Participants were exposed to repeated baseline sessions interrupted with two anxiety-inducing sessions. Results showed that under moderate levels of anxiet...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2005.04.036
更新日期:2005-08-12 00:00:00
abstract::Deep brain stimulation (DBS) of the anterior limb of the internal capsule (ALIC) may be effective in treating depression. Parental verbal abuse has been linked to decreased fractional anisotropy (FA) of white matter and reduced FA correlated with depression and anxiety scores. Utilizing a nonhuman primate model of moo...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2010.06.012
更新日期:2010-08-16 00:00:00
abstract::Post-stroke 'pushing' behaviour appears to be caused by impaired perception of vertical in the roll plane. While pushing behaviour typically resolves with stroke recovery, it is not known if misperception of vertical persists. The purpose of this study was to determine if perception of vertical is impaired amongst str...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2015.02.007
更新日期:2015-03-17 00:00:00
abstract::Changes in contingent negative variation (CNV), a brain-evoked potential related in arousal, as well as in serum triiodothyronine (T3), thyroxine (T4), thyroid-stimulating hormone (TSH), prolactin (PRL), cortisol and growth hormone (GH) levels were recorded in 12 male volunteers receiving either thyrotropin-releasing ...
journal_title:Neuroscience letters
pub_type: 临床试验,杂志文章
doi:10.1016/0304-3940(88)90107-3
更新日期:1988-11-11 00:00:00
abstract::Tacrine (1,2,3,4-tetrahydro-9-acridinamine) inhibited binding of [3H]flunitrazepam to benzodiazepine receptors of guinea pig hippocampus with an inhibition constant of 46 microM at 2 degrees C and 37 degrees C. gamma-Aminobutyric acid (GABA) decreased the affinity of tacrine for the receptor, suggesting that tacrine m...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(91)90473-7
更新日期:1991-08-19 00:00:00
abstract::Serotonin-immunoreactive (5HT-IR) neurons were investigated in the brain and rostral (cervical) spinal cord of the garfish, a non-teleost actinopterygian. The diencephalon contained a prominent 5HT-IR cell group consisting mainly of liquor-contacting neurons in the hypothalamic periventricular wall. Their ependymofuga...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(98)01011-8
更新日期:1999-02-12 00:00:00
abstract:OBJECT:Much evidence has demonstrated that stress and tumor interact, but the mechanisms are poorly understood. The purpose of this study is to discuss the effect of unpredictable chronic mild stress (CMS) upon the behavior of Walker 256 tumor-bearing rats and its mechanism. METHODS:Observe the effects of CMS on the s...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2009.06.031
更新日期:2010-03-31 00:00:00
abstract::Immunoreactive beta-endorphin is localized mainly in the synaptosome-enriched subcellular fraction from rat hypothalami. In this report, we demonstrate that release of immunoreactive beta-endorphin from the synaptosome-enriched subcellular fraction is increased by 150% in a medium containing high potassium. This stimu...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(80)90259-1
更新日期:1980-08-01 00:00:00
abstract::Cultured rat pheochromocytoma cells, PC-12, were found to contain renin-like activity. The activity which was inhibited by monospecific antibodies to rat renal renin showed a pH optimum between 6 and 7, indicating that it was a specific renin. The cells also contained angiotensin I and angiotensin I converting enzyme....
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(84)90433-6
更新日期:1984-05-04 00:00:00
abstract::Using in situ hybridization histochemistry, we have demonstrated that 3 alpha subunit mRNAs of the GABAA receptor are present in different cell populations of the bovine cerebellum. While the alpha 1 mRNA is the most abundant and is present in granule cells, Purkinje cells and stellate/basket cells, the alpha 2 mRNA a...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(89)90193-6
更新日期:1989-11-20 00:00:00
abstract::The cerebral vessels have sympathetic, parasympathetic, and sensory innervations. A sensory innervation of the cerebral vessels originating in the trigeminal ganglion has been described in a number of species by several investigations. It has been shown that the electrical stimulation of the trigeminal ganglion causes...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2004.04.079
更新日期:2004-07-29 00:00:00
abstract::Contact heat evoked potentials (CHEPs) have been difficult to elicit due to slow temperature rise times. A recently developed heat-foil technology was used to elicit pain and CHEPs. Two groups of subjects were separately stimulated at the left arm with contact heat via one fast-acting (70 degrees C/s) heat-foil thermo...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(01)02374-6
更新日期:2001-12-01 00:00:00
abstract::The aim was to examine the effect of handball training on cognitive ability in elderly with mild cognitive impairment. A total of 60 elderly were randomly divided into training group (n=30) and control group (n=30). The mini-mental state examination (MMSE) score and abilities of daily living scale (ADL) score before, ...
journal_title:Neuroscience letters
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.neulet.2014.02.035
更新日期:2014-04-30 00:00:00
abstract::Spinal cord injury (SCI) results in rapid and significant oxidative stress. We have previously demonstrated that polyethylene glycol (PEG) repairs neuronal membrane and inhibits lipid peroxidation in an in vitro model of SCI. In this study we tested the effects of PEG on oxidative stress in guinea pigs after SCI. Oxid...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2004.02.027
更新日期:2004-04-15 00:00:00
abstract::Previous studies have shown an association between diabetes mellitus and impairments in learning and memory. These deficits were partially reversed by the use of insulin. Due to the fact that exercise has positive effects on many physiological systems, including the central nervous system, the present study, evaluated...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2009.03.052
更新日期:2009-05-15 00:00:00
abstract::We assess in mice, the electrophysiological criteria developed in humans and rats in vivo for unmyelinated (C) fibre differentiation into sub-classes, derived from the activity-induced latency increase ("slowing") in response to electrical stimulation during 6 min at 0.25 Hz followed by 3 min at 2 Hz. Fibres are consi...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2015.02.057
更新日期:2015-04-10 00:00:00
abstract::We have used the polyoma middle T oncogene to immortalize cells from rat embryo encephalon. Immunostaining experiments with monoclonal antibodies demonstrated that the cells of one of the obtained lines, named CEINGE CL3, are stained by anti-vimentin and anti-S100 antibodies, are not stained by anti-neurofilaments (NF...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(93)90823-4
更新日期:1993-09-03 00:00:00
abstract::Our previous investigations revealed that progranulin (PGRN) is a lysosomal protein involved in hippocampal neurogenesis and neuroinflammation. However, the possible involvement of PGRN in regulating inflammatory response and mediating neuronal activity is still not well-defined. Here, we demonstrate that PGRN deficie...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2020.134755
更新日期:2020-02-16 00:00:00
abstract::In the present study, the effects of fluvoxamine on the inhibition of gastrointestinal transit, antinociception and hyperlocomotion induced by morphine were investigated in mice. Treatment with morphine (10 mg/kg, subcutaneously (s.c.)) inhibited gastrointestinal transit and hyperlocomotion. These effects were attenua...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(00)01768-7
更新日期:2001-02-16 00:00:00
abstract::The ability to extract invariant relationships from physically varying stimulation is critical for example to categorical perception of complex auditory information such as speech and music. Human subjects were presented with tone pairs randomly varying over a wide frequency range, there being no physically constant t...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(99)00237-2
更新日期:1999-04-23 00:00:00
abstract::To determine whether diabetes mellitus alters the lipid order and composition of cerebral microvessels, streptozotocin-induced diabetic rats were studied after 5 weeks of chronic hyperglycemia. Diabetes did not affect membrane order or the thermotropic transition temperature of cerebral microvessels as determined from...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(92)90007-t
更新日期:1992-10-12 00:00:00