The effect of chronic mild stress on tumor-bearing rats' behavior and its mechanism.

Abstract:

OBJECT:Much evidence has demonstrated that stress and tumor interact, but the mechanisms are poorly understood. The purpose of this study is to discuss the effect of unpredictable chronic mild stress (CMS) upon the behavior of Walker 256 tumor-bearing rats and its mechanism. METHODS:Observe the effects of CMS on the sucrose consumption, activities, body weight and levels of serums TNF-alpha and IL-6 of both tumor-bearing rats and non-tumor-bearing rats, and on the levels of Bcl-2 and the phosphor-ERK1/2 in their hippocampus. RESULTS:CMS can reduce the average sucrose consumption, behavioral scores, body weight gain, expression of Bcl-2 and p-ERK1/2 protein in hippocampus, and increase serums TNF-alpha and IL-6 of both tumor-bearing rats and non-tumor-bearing rats. The stressed tumor-bearing rats had less sucrose consumption, body weight gain and lower behavioral scores, but higher level of serum TNF-alpha than stressed non-tumor-bearing rats. A negative correlation was found between the levels of serum TNF-alpha and sucrose consumption, while a positive correlation between the expression of Bcl-2 protein in hippocampus proper and sucrose consumption. CONCLUSION:CMS can reduce the protein levels of Bcl-2 and p-ERK1/2 in the rats' hippocampus, which contributes to the changes in the rats' behavior caused by CMS. Tumor-bearing rats are prone to behave depressively after the exposure to CMS. Our findings have suggested that the tumor, by increasing the inflammatory reaction, can be taken as a stressor, affecting the hippocampus and consequently causing depression by decreasing the expression of Bcl-2 and p-ERK1/2 in hippocampus.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Xiu LJ,Lin HM,Wei PK

doi

10.1016/j.neulet.2009.06.031

subject

Has Abstract

pub_date

2010-03-31 00:00:00

pages

1-4

issue

1

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(09)00785-X

journal_volume

473

pub_type

杂志文章
  • Differential effects of somatostatin on adenylate cyclase as functional correlate for different brain somatostatin receptor subpopulations.

    abstract::In homogenates of rat hippocampus and striatum, but not substantia nigra, somatostatin (SRIF) inhibits forskolin-activated adenylate cyclase in nanomolar concentrations. However, SRIF can also stimulate adenylate cyclase in micromolar concentrations in homogenates of rat hippocampus and substantia nigra. The SRIF octa...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(89)90321-2

    authors: Markstein R,Stöckli KA,Reubi JC

    更新日期:1989-09-25 00:00:00

  • Projections from the central nucleus of the amygdala to the gastric related area of the dorsal vagal complex: a Phaseolus vulgaris-leucoagglutinin study in rat.

    abstract::Electrophysiological and anatomic studies suggest that the amygdala regulates gastrointestinal motility and gastric acid secretion via projections to the dorsal vagal complex. The topography of these projections is poorly understood. Here, these projections were investigated by injecting anterograde tracer, Phaseolus ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(00)01392-6

    authors: Liubashina O,Jolkkonen E,Pitkänen A

    更新日期:2000-09-15 00:00:00

  • Guanethidine evokes vasodilatation in guinea pig mesenteric artery by acting on sensory nerves.

    abstract::In precontracted, endothelium-free guinea pig mesenteric artery rings, in which adrenergic vasoconstrictor responses had been eliminated, guanethidine (1-30 microM) produced a vasodilatation of 69.3+/-4.4%. The vasodilatation was reduced 89% by capsaicin (10 microM) or 55% by tetrodotoxin (10 microM), indicating media...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(00)01234-9

    authors: Zheng ZL,Shimamura K,Anthony TL,Kreulen DL

    更新日期:2000-07-21 00:00:00

  • Up-regulation of Hrk, a regulator of cell death, in retinal ganglion cells of axotomized rat retina.

    abstract::Hrk, a regulator of cell death, belongs to the family of pro-apoptotic BH3-only proteins and is known to induce apoptosis in nerve tissue. We examined Hrk gene expression to clarify the role of BH3-only proteins in apoptosis of retinal ganglion cells (RGCs) after optic nerve transection in the adult rat. Reverse trans...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(01)02487-9

    authors: Wakabayashi T,Kosaka J,Hommura S

    更新日期:2002-01-25 00:00:00

  • Early maternal deprivation induces alterations in brain-derived neurotrophic factor expression in the developing rat hippocampus.

    abstract::The effects of maternal deprivation (MD) during early postnatal life on the brain-derived neurotrophic factor (BDNF) level were investigated in the present study. Wistar rats were assigned to either maternal deprivation or mother-reared control (MRC) groups. MD manipulation was achieved by separating rat pups from the...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2004.09.012

    authors: Kuma H,Miki T,Matsumoto Y,Gu H,Li HP,Kusaka T,Satriotomo I,Okamoto H,Yokoyama T,Bedi KS,Onishi S,Suwaki H,Takeuchi Y

    更新日期:2004-11-30 00:00:00

  • Selective activation of phosphoinositide hydrolysis by a rigid analogue of glutamate.

    abstract::Ibotenate and trans-D,L-1-amino-1,3-cyclopentanedicarboxylic acid (trans-ACPD) are rigid analogues of glutamate. Ibotenate has been shown to activate phosphoinositide hydrolysis in rat brain slices. We now report that trans-ACPD also stimulates phosphoinositide hydrolysis but with much higher potency and efficacy than...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(90)90555-n

    authors: Desai MA,Conn PJ

    更新日期:1990-02-05 00:00:00

  • Involvement of sialic acid in high-affinity uptake of dopamine by synaptosomes from rat brain.

    abstract::The high-affinity, sodium-dependent uptake of dopamine (DA) was inhibited by the pretreatment of synaptosomes with neuraminidase from Vibrio cholerae. The inhibition was of a non-competitive type, resulting in a 40% decrease of Vmax. Neither basal nor depolarization-stimulated release of DA was affected. Treatment of ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(87)90179-0

    authors: Zaleska MM,Erecińska M

    更新日期:1987-11-10 00:00:00

  • Stimulatory effect of free fatty acids on growth hormone releasing hormone secretion by fetal rat neurons in monolayer culture.

    abstract::The effects of free fatty acids (FFAs) on growth hormone releasing hormone (GHRH) secretion by fetal rat cortical and hypothalamic neurons in monolayer culture have been investigated. Treatment with caprylic or oleic acids for 90 min, induced a dose-dependent increase in GHRH secretion. The stimulatory effect of capry...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(92)90140-3

    authors: Señaris RM,Lewis MD,Lago F,Dominguez F,Scanlon MF,Dieguez C

    更新日期:1992-01-20 00:00:00

  • Postcentral neurons of alert monkeys activated by the contact of the hand with objects other than the monkey's own body.

    abstract::In the caudal postcentral finger region near or in the anterior bank of the intraparietal sulcus of alert monkeys, we found neurons that were activated selectively by the contact of the hand to certain common objects such as bottle brushes, acrylic plates, parts of the stabilized monkey's chair, etc. All of these neur...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(95)11302-d

    authors: Iwamura Y,Tanaka M,Hikosaka O,Sakamoto M

    更新日期:1995-02-17 00:00:00

  • Cerebellar granule cell survival and maturation induced by K+ and NMDA correlate with c-fos proto-oncogene expression.

    abstract::Persistent depolarization with a high K+ concentration (30 mM) or sustained activation of N-methyl-D-aspartate (NMDA) receptors (12.5 mM K+ plus 100 microM NMDA) enhance both survival and maturation of mouse cerebellar granule neurons in vitro taking as criteria the amount of protein and DNA and the release of endogen...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(89)90790-8

    authors: Didier M,Roux P,Piechaczyk M,Verrier B,Bockaert J,Pin JP

    更新日期:1989-12-15 00:00:00

  • Glial fibrillary acidic protein (GFAP)-immunoreactive astrocytes are increased in the hypothalamus of androgen-insensitive testicular feminized (Tfm) mice.

    abstract::In the hypothalamus of androgen-insensitive testicular feminized (Tfm) mice the normal pattern of immunohistochemical staining for glial fibrillary acidic protein (GFAP) is markedly different from normal. Along the borders of the third ventricle and in the dorsomedial and arcuate nuclei, the numbers of stained astrocy...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(90)90252-5

    authors: McQueen JK,Wright AK,Arbuthnott GW,Fink G

    更新日期:1990-10-02 00:00:00

  • Glutamate-induced deporalization in earthworm ventral nerve cord.

    abstract::We investigated glutamate-induced neuron response in the ventral nerve cord of the earthworm (Eisenia foetida) using a voltage-sensitive dye-imaging technique. Isolated earthworm ganglia were stained by fluorescence voltage-sensitive dye, RH414, and voltage image was acquired by a conventional charge-coupled device (C...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(94)90930-x

    authors: Oka K,Ogawa H,Fujita S

    更新日期:1994-09-26 00:00:00

  • Elevated plasma S100B concentration is associated with mesial temporal lobe epilepsy in Han Chinese: a case-control study.

    abstract::Mesial temporal lobe epilepsy (MTLE) is a common type of intractable epilepsy characterized by astroglial gliosis. The S100B was viewed as an astrocyte marker and experimental studies indicated that S100B might be involved in the pathophysiology of temporal lobe epilepsy. In this study, we measured plasma S100B levels...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2010.08.036

    authors: Lu C,Li J,Sun W,Feng L,Li L,Liu A,Li J,Mao W,Wei H,Gao L,Zhang X,Huang Z,Meng X,Wang Y

    更新日期:2010-10-29 00:00:00

  • Sexual differences and seasonal variations in vasoactive intestinal peptide immunoreactivity in the suprachiasmatic nucleus of jerboa (Jaculus orientalis).

    abstract::The sexual differences and the seasonal variation in the vasoactive intestinal peptide (VIP) content of the suprachiasmatic nucleus (SCN) of a desert rodent, the jerboa (Jaculus orientalis) were studied using immunocytochemical techniques. During the period of sexual activity (spring-early summer), the VIP immunoreact...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(92)90708-f

    authors: Lakhdar-Ghazal N,Kalsbeek A,Pevet P

    更新日期:1992-09-14 00:00:00

  • Biperiden (an M1 antagonist) reduces memory consolidation of cocaine-conditioned place preference.

    abstract::It is well-known that cocaine dependence is a public health issue, and several studies stress the need to look for new and more effective treatments. Although the mesolimbic dopamine (DA) system, which originates in the ventral tegmental area (VTA) and projects to several forebrain structures, is known to be criticall...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2012.01.073

    authors: Zacarias MS,Ramos AC,Alves DR,Galduróz JC

    更新日期:2012-04-04 00:00:00

  • Role of the orexinergic system in acute haemorrhage in the rat.

    abstract::Orexins (OXs) stimulate sympathetic nerve activity to increase arterial pressure (AP) and heart rate (HR). We have previously reported that the OX(1)-receptor antagonist SB-334867 reversed the sympathomimetic actions of orexin A (OXA). In the present study we have investigated the role(s) of the orexinergic system in ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2007.12.015

    authors: Hirota K,Kushikata T,Yoshida H,Kudo M,Kudo T

    更新日期:2008-02-20 00:00:00

  • Effects of movement direction upon kinematic characteristics of vertical arm pointing movements in man.

    abstract::Vertical arm pointing movements in two directions (upwards and downwards), imposing two different loads (unload and 0.5 kg) and speeds (normal and fast) have been studied in six subjects. Movements were recorded using an optoelectronic system. Data analysis concentrated upon finger-tip kinematics. Significant effects ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(98)00604-1

    authors: Papaxanthis C,Pozzo T,Stapley P

    更新日期:1998-09-04 00:00:00

  • Activation of Src tyrosine kinase in microglia in the rat hippocampus following transient forebrain ischemia.

    abstract::To better understand the pathophysiological role of Src protein, a non-receptor protein tyrosine kinase of 60kDa, in the ischemic brain, we investigated the time course and regional distribution of active Src expression by using a specific antibody against Tyr416 phosphorylated Src (phospho-Src) in the rat hippocampus...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2005.01.015

    authors: Choi JS,Kim HY,Chung JW,Chun MH,Kim SY,Yoon SH,Lee MY

    更新日期:2005-05-20 00:00:00

  • Nitric oxide synthase immunoreactivity and NADPH-diaphorase activity in a subpopulation of intrinsic neurones of the guinea-pig heart.

    abstract::This is the first report of the presence of nitric oxide synthase (NOS) immunoreactivity and NADPH-diaphorase (NADPH-d) activity in a subpopulation of the intrinsic neurones that innervate the heart. A cytochemical technique to detect NADPH-d and antisera raised against purified rat cerebellar NOS were employed to exa...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(92)90234-x

    authors: Hassall CJ,Saffrey MJ,Belai A,Hoyle CH,Moules EW,Moss J,Schmidt HH,Murad F,Förstermann U,Burnstock G

    更新日期:1992-08-31 00:00:00

  • Self-generated rapid taps directed to the opposite forearm in man: anticipatory reduction in the muscle activity of the target arm.

    abstract::A brief hammer tap applied passively (by the experimenter) to the forearm elicits a short-latency reflex response in the forearm flexors and extensors. When the same tap is performed actively (by the subject) using the opposite forearm, the reflex response is preceded by a short-lasting anticipatory reduction in the m...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(93)90812-y

    authors: Struppler A,Gerilovsky L,Jakob C

    更新日期:1993-09-03 00:00:00

  • N400 as an index of uncontrolled categorization processing in brand extension.

    abstract::This study examined the ERP (event-related potential) correlates of categorization processing in brand extension with irrelative task. Participants faced two sequential stimuli in a pair consisting of a soft drink brand name (S1) and a product name (S2) which comprised two categories: beverage (typical product of the ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2012.07.043

    authors: Wang X,Ma Q,Wang C

    更新日期:2012-09-06 00:00:00

  • Persistent c-fos expression and NADPH-d reactivity in the medulla and the lumbar spinal cord in rat with short-term peripheral anosmia.

    abstract::Here we examine hypothesis that short-term peripheral ZnSO(4)-induced anosmia can produce effects on c-fos expression within spinal cord and caudal medulla in male Wistar rats (n=4). Fos-like-immunoreactive cells revealed by avidin-biotin-peroxidase method show a significant bilateral increase in the nucleus proprius ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(01)01623-8

    authors: Kalueff AV,Maisky VA,Pilyavskii AI,Makarchuk NE

    更新日期:2001-03-30 00:00:00

  • Tyrosine augments clozapine-induced dopamine release in the medial prefrontal cortex of the rat in vivo: effects of access to food.

    abstract::It has been reported that tyrosine administration augments clozapine-induced dopamine (DA) release in the medial prefrontal cortex (MPFC). To characterize this effect and exclude possible confounds, we conducted a series of studies in which microdialysate collection started 24 h after probe implantation, a time at whi...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2003.11.060

    authors: Jaskiw GE,Simpson C,Bongiovanni R,Yamamoto BK

    更新日期:2004-02-26 00:00:00

  • Generator mechanisms of epileptic potentials analyzed by dipole tracing method.

    abstract::A new dipole tracing method, based on a realistic head model, was used to determine dipole locations and vector moments of interictal convexity sharp waves recorded (with conventional EEG technique) from the right fronto-temporal region in a patient with partial complex seizures. When the dipole locations in the head ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(90)90300-x

    authors: Homma S,Nakajima Y,Musha T,Okamoto Y,Hagbarth KE,Blom S,Flink R

    更新日期:1990-05-31 00:00:00

  • Multi-organ investigation in 16 CADASIL families from central Italy sharing the same R1006C mutation.

    abstract::Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) may involve many target organs with relevant variability among affected individuals. We performed a multi-organ assessment tapping nervous system, skeletal muscle and cardiovascular system in thirty-nine individuals be...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2011.10.062

    authors: Ragno M,Pianese L,Cacchiò G,Manca A,Scarcella M,Silvestri S,Di Marzio F,Caiazzo AR,Silvaggio F,Tasca G,Mirabella M,Trojano L

    更新日期:2012-01-06 00:00:00

  • Acute excitotoxicity in chick retina caused by the unusual amino acids BOAA and BMAA: effects of MK-801 and kynurenate.

    abstract::beta-N-Oxalylamino-L-alanine (BOAA) and beta-N-methylamino-L-alanine (BMAA) were tested for their ability to produce acute excitotoxicity in in embryonic chick retina. gamma-Aminobutyric acid (GABA) release and histology were monitored in retina treated with various concentrations of BOAA, BMAA, kainate (KA), N-methyl...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(89)90093-1

    authors: Zeevalk GD,Nicklas WJ

    更新日期:1989-07-31 00:00:00

  • Nicotine activation of neuronal nitric oxide synthase and guanylyl cyclase in the medulla increases blood flow of the common carotid artery in cats.

    abstract::Individual activation of nicotinic acetylcholine receptor (nAChR) or nitric oxide (NO) synthase in the dorsal facial area (DFA) increases blood flow of common carotid artery (CCA) supplying intra- and extra-cranial tissues. We investigated whether the activation of nAChR initiated the activation of NO synthase and gua...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2010.08.072

    authors: Gong CL,Leung YM,Huang YP,Lin NN,Hung YW,Lee TJ,Kuo JS

    更新日期:2010-12-17 00:00:00

  • Neuropsychological evidence that somatic stimuli are spatially coded according to multiple frames of reference in a stroke patient with tactile extinction.

    abstract::A right-brain damaged patient with pure tactile extinction was asked to report series of single or double light, brief touches delivered to both hands, the thumb or the pinkie of a single hand, the sides of a single index. The stimulated hand was positioned palm up or palm down, in front of or behind the patient, in a...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(00)01157-5

    authors: Tinazzi M,Ferrari G,Zampini M,Aglioti SM

    更新日期:2000-06-23 00:00:00

  • Lithium and oxidative stress lessons from the MPTP model of Parkinson's disease.

    abstract::Lithium has been successfully employed therapeutically for treatment of bipolar depressive illness; however, its mechanism of action is poorly understood. Recently, it has been demonstrated by us that lithium can prevent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) dopaminergic neurotoxicity in mice. From analy...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2012.03.055

    authors: Arraf Z,Amit T,Youdim MB,Farah R

    更新日期:2012-05-10 00:00:00

  • Solubilization and immunopurification of rat brain synaptic vesicle protein 2A with maintained binding properties.

    abstract::This study reports the solubilization of the rat synaptic vesicle protein SV2A, the brain binding site for the antiepileptic drug levetiracetam (LEV), and its characterization. N-dodecyl-beta-D-maltoside (DDM) was the best detergent at achieving a high percentage of SV2A solubilization and at maintaining the binding c...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2005.12.059

    authors: Lambeng N,Grossmann M,Chatelain P,Fuks B

    更新日期:2006-05-01 00:00:00