当前位置： SCI文献检索 > NEUROSCIENCE LETTERS期刊下所有文献 > Biperiden (an M1 antagonist) reduces memory consolidation of cocaine-conditioned place preference.

Biperiden (an M1 antagonist) reduces memory consolidation of cocaine-conditioned place preference.

Abstract：

:It is well-known that cocaine dependence is a public health issue, and several studies stress the need to look for new and more effective treatments. Although the mesolimbic dopamine (DA) system, which originates in the ventral tegmental area (VTA) and projects to several forebrain structures, is known to be critically involved in the neurobiology of cocaine dependence, acetylcholine (ACh) has also been shown to play an important role in cocaine dependence via its action on this reward system. ACh is also important in the formation of hippocampal memory associated with appetitive behavior. Thus, the aim of this study was to evaluate the effect of biperiden, an ACh antagonist with high affinity for muscarinic M1 type receptors, on the acquisition of cocaine-conditioned place preference (CPP) in mice. The cocaine and biperiden were dissolved in sterile saline and were administered intraperitoneally at a dose of 10mg/kg. The conditioning regime was 8 days long, and the cholinergic antagonist was given immediately at the end of each conditioning session. The test for CPP occurred 24h after the last session. The results showed that animals treated with biperiden spent significantly less time in the cocaine-paired compartment than did the ones treated with saline. This finding represents a reduction in the consolidation of cocaine-induced CPP. One hypothesis that could explain this outcome focuses on the action of cholinergic antagonists on the consolidation of contextual memories. The amnesic effect of M1 antagonists on aversive tasks and on morphine CPP has been demonstrated when administered before the training or the conditioning session. The present study highlights the possibility of impairment in the acquisition of an appetitive memory, even when the cholinergic drug is administered after the conditioning session. This protocol also rejects the possibility of performance disturbance and suggests a possible pharmacological tool in the treatment of cocaine dependence.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Zacarias MS,Ramos AC,Alves DR,Galduróz JC

doi

10.1016/j.neulet.2012.01.073

subject

Has Abstract

pub_date

2012-04-04 00:00:00

pages

129-31

issue

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(12)00154-1

journal_volume

513

pub_type

杂志文章

在线工具

Biperiden (an M1 antagonist) reduces memory consolidation of cocaine-conditioned place preference.