Abstract：
:The effect of Ca2+/calmodulin-dependent protein phosphorylation on K+ channels was examined in snail neurons, using several pharmacological agents, the voltage clamp method and the pressure injection technique. H-7, a general protein kinase inhibitor, reduced the delayed outward K+ current (IKD) which was suppressed by tetraethylammonium. Ca2+/calmodulin-dependent protein kinase II, when injected into neurons which had been treated with H-7, transiently restored the reduced IKD nearly to the pre-H-7 level. However, this restoration was blocked by W-7, a calmodulin inhibitor. In contrast, the catalytic subunit of cAMP-dependent protein kinase or protein kinase C injected into the H-7-treated neurons had little effect on the current. These findings suggest that Ca2+/calmodulin-dependent protein phosphorylation is involved in the opening process of K+ channels.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Onozuka M,Furuichi H,Imai S,Fukami Ydoi
10.1016/0304-3940(91)90816-ckeywords:
subject
Has Abstractpub_date
1991-03-11 00:00:00pages
35-8issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(91)90816-Cjournal_volume
124pub_type
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