Analysis of a neuronal antigen (Hu) expression in the developing rat brain detected by autoantibodies from patients with paraneoplastic encephalomyelitis.

Abstract:

:Anti-Hu is an autoantibody that recognizes an antigen (Hu) highly restricted to neuronal nuclei. In the developing rat brain all neurons and the germinal cell layer were anti-Hu positive. Ependyma and choroid plexus were positive only in the early stages of development. The strongest expression of Hu was seen in the most mature neurons. The transitory nature of Cajal-Retzius and subplate neurons was confirmed with the anti-Hu staining. Although the Hu is also expressed by neural cells other than neurons, the strongest staining of mature neurons could indicate that Hu plays a role in the process of neuronal differentiation.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Graus F,Ferrer I

doi

10.1016/0304-3940(90)90314-y

subject

Has Abstract

pub_date

1990-04-20 00:00:00

pages

14-8

issue

1

eissn

0304-3940

issn

1872-7972

pii

0304-3940(90)90314-Y

journal_volume

112

pub_type

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