Abstract：
:Since the mRNA level of Fyn, a neurodevelopmental molecule, expression had been reported to be increased in postmortem schizophrenic prefrontal cortex and showed a strong correlation with age of disease onset, we investigated whether the three polymorphisms of the Fyn gene on genomic DNA (-93A/G, IVS10+37T/C and Ex12+894T/G) also had an effect on clinical onset in 139 unrelated schizophrenics. A comparison of the age of onset among the groups classified by polymorphisms showed no significant difference. Moreover, all allelic combinations also failed to show significant differences in age of onset among the groups. The present study reports that there is no indication that the three polymorphisms in the Fyn gene are associated with the age of schizophrenic onset.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Ohnuma T,Shibata N,Matsubara Y,Sato S,Yamashina M,Arai Hdoi
10.1016/s0304-3940(03)00310-0keywords:
subject
Has Abstractpub_date
2003-05-29 00:00:00pages
70-2issue
1eissn
0304-3940issn
1872-7972pii
S0304394003003100journal_volume
343pub_type
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