Abstract:
:With the use of an antiserum against human apelin-36, apelin-immunoreactivity (irAP) was detected in neurons and cell processes of the supraoptic nucleus (SO), paraventricular nucleus (PVH), accessory neurosecretory nuclei (Acc) and suprachiasmatic nucleus. Strongly labeled cells/processes were noted in the internal layer of the median eminence, infundibular stem, anterior and posterior pituitary. Double-labeling the sections with goat polyclonal neurophysin I-antiserum and rabbit polyclonal apelin-antiserum revealed a population of magnocellular neurons in the PVH, SO and Acc expressing both irAP and neurophysin I-immunoreactivity (irNP), the latter being a marker of oxytocin-containing neurons. By inference, the AP-positive but irNP-negative magnocellular neurons could be vasopressin-containing. The presence of irAP in certain hypothalamic nuclei and pituitary suggests that the peptide may be a signaling molecule released from the hypothalamic-hypophysial axis.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Brailoiu GC,Dun SL,Yang J,Ohsawa M,Chang JK,Dun NJdoi
10.1016/s0304-3940(02)00411-1keywords:
subject
Has Abstractpub_date
2002-07-26 00:00:00pages
193-7issue
3eissn
0304-3940issn
1872-7972pii
S0304394002004111journal_volume
327pub_type
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