Abstract：
:Cortical spreading depression (SD) may produce some symptoms of the aura of classical migraine but it is less probable that it can account for the headache. The aversiveness of SD was examined in unanesthetized rats. In Exp. 1, rats with implanted cortical cannulae were confined in the dark compartment of the step-through apparatus and repeated waves of SD were elicited in one hemisphere. After two such training sessions the rats did not evince passive avoidance of the compartment associated with cortical SD. In Exp. 2, thirsty rats with implanted hippocampal electrodes were trained to drink from two different spouts A and B. Hippocampal SD was elicited when the animal was drinking from spout A but not from spout B. Drinking was interrupted shortly after appearance of the SD wave and gradually recovered over the subsequent 10 min, but up to ten spout A-SD pairings did not change the animal's preference for spout A. It is concluded that cortical or hippocampal SD has no immediate or delayed aversive consequences.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Koroleva VI,Bures Jdoi
10.1016/0304-3940(93)90759-esubject
Has Abstractpub_date
1993-01-12 00:00:00pages
153-6issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(93)90759-Ejournal_volume
149pub_type
杂志文章abstract：:Growth factors are major signaling agents regulating neuron-glia dialogue. Epidermal growth factor (EGF), basic fibroblast growth factor (bFGF), insulin growth factor-I (IGF-I) and insulin (INS) induce neuronal and astroglial cell proliferation and differentiation. This is true also for estrogens that influence astroc...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2004.01.024
更新日期：2004-04-01 00:00:00
abstract：:The present experiment investigated cortical responses of native Italian subjects during reading of short sentences including semantic or morphosyntactic violations. Given the specificity of the Italian language in which the sequencing of words is relatively more free than in English or other languages, we investigate...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(01)02528-9
更新日期：2002-03-29 00:00:00
abstract：:Dysbindin gene (DTNBP1) has been associated with schizophrenia, but literature findings are inconsistent, and further analyses are required. This study is aimed to investigate if a set of DTNBP1 variations might influence clinic psychotic phenotype or treatment response in a sample of 240 Korean schizophrenic in-patie...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2008.05.069
更新日期：2008-08-01 00:00:00
abstract：:A cDNA clone encoding a novel protein (Cer-1) was isolated from a mouse cerebellar cDNA library. The deduced amino acid sequence of Cer-1 is not homologous to other sequences in the protein sequence data base. RNA blot analysis suggests that expression of Cer-1 RNA occurs selectively in the adult cerebellum and in pur...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(96)12628-8
更新日期：1996-05-10 00:00:00
abstract：:The endogenously synthesized nonapeptide arginine vasopressin (AVP) is thought to be involved in transduction of photic information to the pineal gland. The enhancement of circulating AVP leads to a suppression of the nocturnal melatonin surge the mechanisms of which are unknown so far. We therefore studied the effect...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(91)90175-s
更新日期：1991-02-11 00:00:00
abstract：:Specific (nerve growth factor, NGF) and non-specific (serum albumin, BSA) uptake followed by retrograde axonal transport was studied in the sciatic nerves of normal (C57BL/6J) and dystrophic (dy2J/dy2J) mice. In the dystrophic mouse there was a significant decrease in the amount of NGF transported to dorsal root gangl...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(82)90177-x
更新日期：1982-12-31 00:00:00
abstract：:A free radical scavenger edaravone is clinically used in Japan for acute stroke, and several basic researches have carefully examined the mechanisms of edaravone's protective effects. However, its actions on pro-inflammatory responses under stroke are still understudied. In this study, we subjected adult male Sprague-...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2016.08.048
更新日期：2016-10-28 00:00:00
abstract：:Sympathoexcitatory neurons in the C1 adrenergic area of the rostral ventrolateral medulla (RVL) are tonically inhibited by gamma-aminobutyric acid (GABA). To identify the source of this GABAergic input, the distribution of neurons containing glutamate decarboxylase (GAD) was determined immunocytochemically in rats tre...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(85)90333-7
更新日期：1985-07-04 00:00:00
abstract：:Transcranial pulsed current stimulation (tPCS) is a non-invasive brain stimulation technique that employs weak, pulsed current at different frequency ranges, inducing electrical currents that reach cortical and subcortical structures. Very little is known about its effects on brain oscillations and functional connecti...
journal_title：Neuroscience letters
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.neulet.2014.06.021
更新日期：2014-08-08 00:00:00
abstract：OBJECTIVE:Mesenchymal stem cells (MSCs) are widely used in regeneration and repair of various tissues and organs, and whether MSC-conditioned medium (MSC-CM) has protective effects in postoperative cognitive dysfunction (POCD) remains largely unknown. We aimed to assess the therapeutic effect and explore the mechanisms...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2019.134372
更新日期：2019-09-14 00:00:00
abstract：:Studies of cognitive behavior in rodent models of Alzheimer's disease (AD) are the mainstay of academic and industrial efforts to find effective treatments for this disorder. However, in the majority of such studies, the nature of rodent behavioral tests is considerably different from the setting associated with cogni...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2017.04.049
更新日期：2017-05-22 00:00:00
abstract：:Damage to sub-cortical white matter is a key substrate of vascular dementia (VaD) leading to deficits in executive function and cognitive processing speed. Dynamin1 is a 100 kDa protein, accounting for 0.4% of the total brain protein, and has a central role in many intracellular processes such as synaptic vesicle traf...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2014.01.045
更新日期：2014-03-20 00:00:00
abstract：:Spirulina maxima is a blue-green micro alga that contains abundant amounts of proteins (60-70%), vitamins, chlorophyll a, and C-phycocyanin (C-PC). It has been shown to reduce oxidative stress, and prevent diabetes and non-alcoholic fatty liver disease. However, it is unclear whether Spirulina maxima 70% ethanol extra...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2018.02.057
更新日期：2018-04-23 00:00:00
abstract：:The expression of class I and class II histocompatibility antigens by myelin basic protein (MBP)-positive oligodendrocytes, in response to exogenous cytokines, has been investigated in vitro. It has been found that interferon-gamma (IFN-gamma), although capable of class I induction, does not induce class II on oligode...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(91)90154-l
更新日期：1991-02-11 00:00:00
abstract：:In this study, we have developed a microarray including 1467 cDNAs that were selected to specifically measure stress response in peripheral blood leukocytes. Venous blood was collected from 10 graduate students 2 h before and 2 or 24 h after an open presentation for their Ph.D. The mRNA levels in leukocytes were compa...
journal_title：Neuroscience letters
pub_type： 临床试验,杂志文章
doi：10.1016/j.neulet.2005.01.081
更新日期：2005-06-10 00:00:00
abstract：:N-Methyl-D-aspartate (NMDA, 500 ng/0.5 microliters), alpha-amino-3-hydroxy-5-methyl-4-isoxasole-propionic acid (AMPA, 1000 ng/0.5 microliters), or kainic acid (50 ng/0.5 microliters) injected into intermediate and caudal parts of the caudate-putamen induced contralateral head turns and rotations. Picrotoxin (250 ng/0....
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(95)12198-6
更新日期：1995-12-29 00:00:00
abstract：:The objective of this study was to determine if yohimbine, a central norepinephrine enhancing drug, increases cortico-motoneuronal excitability in intact humans. Transcranial magnetic stimulation was used to assess excitability of the motor system reflected in the parameters motor threshold, recruitment curve, intraco...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(01)01921-8
更新日期：2001-07-06 00:00:00
abstract：:The adenosine triphosphate (ATP)-dependent sodium/potassium pump extrudes intracellular sodium in exchange for extracellular potassium. Low ATP causes pump dysfunction increasing both intracellular sodium and water thereby enhancing metabolite mobility. This should be detectable by proton magnetic resonance spectrosco...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(94)90797-8
更新日期：1994-12-05 00:00:00
abstract：:Purinoceptor agonists produced potassium currents with the order of potency: ATP > adenosine = ADP = AMP > beta,gamma-methylene ATP, while a small response or no response was induced by 2-methylthio ATP, UTP, or alpha,beta-methylene ATP. The response induced by beta,gamma-methylene ATP was completely inhibited in the ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(98)00337-1
更新日期：1998-05-29 00:00:00
abstract：:The horizontal vestibulo-ocular reflex (VOR) of two groups of rats was measured. One group was bred and kept under hypergravity (HG; 2.5 g) conditions, the other group lived under normal gravity (NG; 1 g). Eye position was recorded in response to horizontal rotatory stimuli. Measurements were made under NG (1 g), and ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(01)01691-3
更新日期：2001-04-27 00:00:00
abstract：:A restricted recovery of visual excitation occurs in the partially deafferented dorsal lateral geniculate nucleus (dLGN) of the cat after retinal lesions. In the absence of axonal growth an increase of retinogeniculate synapses at the peripheral dendrites of deafferented cells could be a possible underlying mechanism....
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(84)90157-5
更新日期：1984-08-24 00:00:00
abstract：:Reduced supply of glucose involves in many pathological conditions such as stroke and contributes to ischemic injuries. In contrast, hyperglycemia has also been regarded as an important factor in causing and exaggerating stroke damage. Although the molecular mechanism(s) of imbalanced glucose-induced cellular injuries...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2006.09.066
更新日期：2006-12-13 00:00:00
abstract：:We evaluated long-term dynorphin A-immunoreactivity in the rat area postrema (AP) after the administration of cisplatin. First, rats were given 1, 5 and 10mg/kg body weight cisplatin (i.p.) and their behavior was monitored for 72h. We observed a delayed increase in pica 24-72h after injection, compared to the 24h befo...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2007.07.044
更新日期：2007-09-07 00:00:00
abstract：:Antidepressants such as tricyclic antidepressants, and serotonin noradrenaline reuptake inhibitors are a first-line treatment for neuropathic pain. Here, we aimed to determine the involvement of the spinal dopaminergic system in the antihyperalgesic effects of antidepressants in a rat model of neuropathic pain induced...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2017.04.017
更新日期：2017-05-10 00:00:00
abstract：:Corticokinematic coherence (CKC), i.e., coherence calculated between MEG and an accelerometer signal, recording movement kinematics, can be used for functional mapping of the sensorimotor cortex. Cortical sources of CKC, induced by both voluntary and passive movements, localize at the proximity of sensorimotor cortex....
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2015.06.034
更新日期：2015-08-18 00:00:00
abstract：:By means of light microscopic autoradiography, binding sites for the gamma-aminobutyric acid (GABA) analogues, 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol ([7-3H]THIP), [3H]isoguvacine and [3H]baclofen were found on many cultured cerebellar and spinal neurons of fetal and newborn rats. The number of neurons labelle...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(85)90417-3
更新日期：1985-10-24 00:00:00
abstract：:Intra- and extracellular recordings from the in vitro rat hippocampal slice preparation have been used to investigate the influence of serotoninergic, adrenergic and cholinergic receptor antagonists on the excitability of CA1 pyramidal neurones. The serotonin receptor antagonist 4-amino-N-(1-azabicyclo[2.2.2]oct-3yl)-...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(95)12063-a
更新日期：1995-10-27 00:00:00
abstract：:We have previously shown that glycine binding sites on presynaptic NMDA receptors (NMDA-Rs) can tonically regulate glutamate release in the rat visual cortex. In the present study, we investigated the subunit composition of these presynaptic NMDA-Rs. We recorded miniature a-amino-3-hydroxy-5-methyl-4-isoxazolepropioni...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2007.12.023
更新日期：2008-02-27 00:00:00
abstract：:The aim of the present study is to investigate the effects of orphanin FQ (OFQ) microinjected into the nucleus raphe magnus (NRM) and the nucleus reticularis gigantocellularis (NGC) on pain modulation. The tail-flick latency (TFL) was used as a behavioral index of nociceptive responsiveness. The result showed microinj...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(01)01874-2
更新日期：2001-06-22 00:00:00
abstract：:Intracortical facilitatory and inhibitory processes in the primary motor cortex (M1) play an important role in both the preparation and execution of motor tasks. Here we aimed to (1) confirm the existence of, and further characterise, intracortical facilitation at long conditioning-test stimulus intervals at subthresh...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2014.03.060
更新日期：2014-06-06 00:00:00
