Growth factor-estradiol interaction on DNA labeling and cytoskeletal protein expression in cultured rat astrocytes.

abstract：:Personalized or precision medicine is a medical discipline that proposes tailoring health care to each individual by integrating data from their genetic makeup, epigenetic modifications, other biomarkers, clinical symptoms and environmental exposures. Currently, patients typically present for treatment of mood disorde...

journal_title：Neuroscience letters

authors： Prendes-Alvarez S,Nemeroff CB

更新日期：2018-03-16 00:00:00

abstract：:Gastrin releasing peptide (GRP) is involved in the stimulation of gastric acid release from the stomach. It also mediates effects on feeding behavior. It is associated with anorexigenic effects in both mammalian and avian species, but the mechanism of action is unknown in any species. The aim of the present study was ...

journal_title：Neuroscience letters

authors： Bohler M,Dougherty C,Tachibana T,Gilbert ER,Cline MA

更新日期：2019-11-20 00:00:00

abstract：:A peptide consisting of residues 25-35 of the amyloid beta protein was applied to single neurons while monitoring membrane current by whole cell voltage clamp recording. Within minutes of direct exposure of a neuron to the amyloid beta peptide, a paroxysmal increase in neuronal membrane conductance was observed. This ...

journal_title：Neuroscience letters

authors： Simmons MA,Schneider CR

更新日期：1993-02-19 00:00:00

abstract：:Unilateral intraplantar injections (1/day for 3 days) of 4 mu g nerve growth factor (NGF) into the rat hindpaw increased the expression of prepro-tachykinin (PPT)- and prepro-calcitonin gene-related peptide (ppCGRP)-mRNA in bilateral L5 dorsal root ganglia (DRGs). This was accompanied by an increase of CGRP-like immun...

journal_title：Neuroscience letters

authors： Amann R,Sirinathsinghji DJ,Donnerer J,Liebmann I,Schuligoi R

更新日期：1996-01-26 00:00:00

abstract：:The cingulum, a major structure of the limbic system, is closely associated with memory function. In the current study, we investigated aging of the cingulum according to the location of the cingulum in each part of the cingulum after dividing the cingulum into five parts in normal subjects, using DTT parameters (frac...

journal_title：Neuroscience letters

authors： Jang SH,Kwon YH,Lee MY,Kim JR,Seo JP

更新日期：2016-01-01 00:00:00

abstract：:Localized moderate cooling (+10 degrees C) of the anterior and ventral part of the raphe dorsalis induced cortical synchronization and ponto-geniculo-occipital (PGO) waves followed sometimes by paradoxical sleep. Cooling the region of the raphe magnus produced cortical arousal. After depletion of brain 5-hydroxytrypta...

journal_title：Neuroscience letters

authors： Cespuglio R,Walker E,Gomez ME,Musolino R

更新日期：1976-11-01 00:00:00

abstract：:The present study was designed to observe the effect of orphanin FQ (OFQ, also known as 'nociceptin'), a newly-discovered neuropeptide, on pain behavior and morphine analgesia evaluated by formalin test in rats. It was found that intracerebroventricular (i.c.v.) injection of 0.1 microg OFQ had no effect on formalin-in...

journal_title：Neuroscience letters

authors： Zhu CB,Cao XD,Xu SF,Wu GC

更新日期：1997-10-10 00:00:00

abstract：:Mammals navigate a complex environment using a variety of strategies, which can operate in parallel and even compete with one another. We have recently described a variant water maze task in which two of these strategies, hippocampus-dependent spatial learning and striatum-dependent cued learning, can be dissociated. ...

journal_title：Neuroscience letters

authors： Baldan Ramsey LC,Pittenger C

更新日期：2010-10-11 00:00:00

abstract：:The potential of nitric oxide for the induction of reactive oxygen species (ROS) has been evaluated in a cerebral synaptosomal fraction. Nitric oxide (NO) was generated using S-nitroso-N-acetylpenicillamine (SNAP). NO stimulated ROS production, assayed using a fluorescent probe. This stimulation was largely inhibited ...

journal_title：Neuroscience letters

authors： Bondy SC,Naderi S

更新日期：1994-02-28 00:00:00

abstract：:The enzyme Fatty Acid Amide Hydrolase (FAAH) is a key regulator of the endogenous levels of a family of biologically active lipid mediators, the fatty acid amides. These include anandamide, oleoyl ethanolamide and palmitoyl ethanolamide, and their effects are mediated by a variety of downstream targets including canna...

journal_title：Neuroscience letters

authors： Webb M,Luo L,Ma JY,Tham CS

更新日期：2008-07-04 00:00:00

abstract：:We have studied nicotinic acetylcholine receptors in spontaneously hypertensive 'stroke prone' (SHsp) rats. We found a significant decrease in 125I-alpha-bungarotoxin binding and alpha7 subunit mRNA levels in cortical areas of the SHsp rats with respect to Wistar Kyoto (WKy) normotensive rats. Antihypertensive drug tr...

journal_title：Neuroscience letters

authors： Ferrari R,Frasoldati A,Leo G,Torri C,Zini I,Agnati LF,Zoli M

更新日期：1999-12-31 00:00:00

abstract：:The study of neural arousal mechanisms has been greatly aided by the discovery of the orexin peptides (orexin A and orexin B), the subsequent identification of the neurons that synthesize these peptides, their projections in the brain, and the distribution of orexin receptors in the central nervous system. Orexin neur...

journal_title：Neuroscience letters

authors： Brown TM,Coogan AN,Cutler DJ,Hughes AT,Piggins HD

更新日期：2008-12-31 00:00:00

abstract：:Genetic polymorphisms in chemokine receptor and their natural ligand genes have been shown to modify the disease progression of Alzheimer's disease (AD). Human macrophage inflammatory protein-1 alpha (MIP-1alpha) is a chemotactic cytokine which plays a considerable role in AD pathogenesis, but its genetic contribution...

journal_title：Neuroscience letters

authors： Li K,Dai D,Yao L,Gu X,Luan K,Tian W,Zhao Y,Wang B

更新日期：2008-03-12 00:00:00

abstract：:To investigate the actions of glucocorticoids (GCs) on astrocyte functions, interactions of dexamethasone and immediate early genes (IEGs) were studied in cell cultures of rat cerebral cortical astrocytes. Vasoactive intestinal peptide (VIP) induces rapid c-fos mRNA expression and morphological changes (stellation) in...

journal_title：Neuroscience letters

authors： Hisanaga K,Sagar SM,Koistinaho J,Hicks KJ,Sharp FR

更新日期：1993-06-25 00:00:00

abstract：:Motor nerve supplies to 15 poles of rat lumbrical spindle were reconstructed from serial, 1-micron transverse sections of muscle embedded in resin. Neural and muscular elements associated with the modulation of static sensitivity of afferents were deficient in these spindles relative to cat tenuissimus and rat soleus ...

journal_title：Neuroscience letters

authors： Walro JM,Kucera J

更新日期：1985-09-06 00:00:00

abstract：:Accumulating evidence indicates that obesity is an independent risk factor for developing Alzheimer disease (AD). Recent studies have shown that diet-induced obesity (DIO) enhances AD-related pathologies in transgenic mouse models of the disease. DIO increases amyloid β (Aβ) deposition in amyloidogenic transgenic mice...

journal_title：Neuroscience letters

authors： Koga S,Kojima A,Kuwabara S,Yoshiyama Y

更新日期：2014-06-13 00:00:00

abstract：:A calcium-dependent potassium channel K(Ca) has been isolated in mouse motoneurons. With physiological concentrations of potassium across inside-out patches, a 100 pS K(Ca) channel was activated when the bath solution of Ca2+ was in excess of 1 microM. Introduction of the drug tedisamil, a blocker of repolarizing pota...

journal_title：Neuroscience letters

authors： McLarnon JG,Sawyer D,Michikawa M,Kim SU

更新日期：1992-09-14 00:00:00

abstract：:In micturition control, the roles of ionotropic glutamate (iGlu) receptors NMDA and AMPA are well established, whereas little is known about the function of metabotropic glutamate (mGlu) receptors. Since antagonists for mGlu5 receptors are efficacious in animal models of inflammatory and neuropathic pain, we examined ...

journal_title：Neuroscience letters

authors： Hu Y,Dong L,Sun B,Guillon MA,Burbach LR,Nunn PA,Liu X,Vilenski O,Ford AP,Zhong Y,Rong W

更新日期：2009-01-23 00:00:00

abstract：:To determine the role of cytokines in the nervous system, we examined the effect of interleukin-12(IL-12) on the nerve regeneration of mouse superior cervical ganglion cells (SCG). IL-12 enhanced the neurite outgrowth in a concentration-dependent manner. Immunocytochemical studies demonstrated the expression of IL-12 ...

journal_title：Neuroscience letters

authors： Lin H,Hikawa N,Takenaka T,Ishikawa Y

更新日期：2000-01-14 00:00:00

abstract：:In the rat, unilateral intrastriatal injection of monoclonal antibodies to acetylcholinesterase (AChE) produced ipsilateral disappearance of AChE-positive nerve terminals within striatum and adjacent cortex. No alterations in striatal staining patterns were observed for tyrosine hydroxylase, somatostatin, neuropeptide...

journal_title：Neuroscience letters

authors： Bean AJ,Xu Z,Chai SY,Brimijoin S,Hökfelt T

更新日期：1991-11-25 00:00:00

abstract：:Female Fischer 344 (F344) rats were tested for age-related differences in both cerebellar beta-adrenergic receptor activation and motor learning. Three and 20 month old rats were tested on a motor learning paradigm that required the rats to adjust their gait to navigate a runway of unevenly spaced pegs. Rates of acqui...

journal_title：Neuroscience letters

authors： Gould TJ,Bickford PC

更新日期：1996-09-20 00:00:00

abstract：:The intramedullary axon collateral systems of adult cat spinal alpha-motoneurones were studied with morphological and physiological techniques 12 weeks after peripheral transection of the motor axons. Morphologically, intracellular horseradish peroxidase (HRP) staining showed that the axotomy induced an elimination of...

journal_title：Neuroscience letters

authors： Havton L,Kellerth JO

更新日期：1984-11-23 00:00:00

abstract：:Ibotenate induced a concentration- and largely calcium-dependent release of endogenous glutamate from guinea pig cerebro-cortical synaptosomes. In the absence of Mg2+, the response to ibotenate was enhanced through a mechanism involving N-methyl-D-aspartate (NMDA) receptors; this component was sensitive to the NMDA an...

journal_title：Neuroscience letters

authors： Jones PG,Roberts PJ

更新日期：1990-03-26 00:00:00

abstract：:Neurofibromatosis 1 (NF1) is a common autosomal dominant disorder in which affected individuals develop benign and malignant tumors as well as non-tumor-related abnormalities, such as seizures and learning disabilities. Here, we report an NF1 isoform arising from the alternative splicing of exon 9a with predominant ce...

journal_title：Neuroscience letters

authors： Geist RT,Gutmann DH

更新日期：1996-06-21 00:00:00

abstract：:It is debated whether non-affected relatives of patients with affective disorders share a specific brain structure endophenotype. Aim of this work is to explore the medial temporal morphology in affected and non-affected members of a family with mood disorders. Hippocampi and amygdalae were manually traced from the 3D...

journal_title：Neuroscience letters

authors： Boccardi M,Almici M,Bresciani L,Caroli A,Bonetti M,Monchieri S,Gennarelli M,Frisoni GB

更新日期：2010-01-04 00:00:00

abstract：:The phenotypic manifestation of McArdle disease varies considerably from one individual to the next. The purpose of this study was to assess the possible association between the clinical severity of the disease, and each of the genotypes PYGM (R50X), ACE (I/D), AMPD1 (Q12X), PPARGC1A (G482S) and ACTN3 (R577X). We also...

journal_title：Neuroscience letters

authors： Rubio JC,Gómez-Gallego F,Santiago C,García-Consuegra I,Pérez M,Barriopedro MI,Andreu AL,Martín MA,Arenas J,Lucia A

更新日期：2007-07-18 00:00:00

abstract：:The neurotransmitter gamma-aminobuteric acid (GABA) is believed to have a controlling action on spinal locomotor networks. In spasticity, spinal locomotor networks are thought to play a role. A well known drug in the treatment of spasticity is the GABA(B) agonist Baclofen. We report an inhibitory effect of Baclofen on...

journal_title：Neuroscience letters

authors： de Louw AJ,de Vente J,Steinbusch HP,Steinbusch HW,Troost J,Vles JS

更新日期：2002-03-15 00:00:00

abstract：:gamma-Aminobutyric acidA (GABA(A)) gated chloride ion channels were expressed from human recombinant cDNA using the baculovirus/Sf-9 insect cell expression system. The electrophysiological effects in whole-cell currents of 5-(4-piperidyl) isoxazol-3-ol (4-PIOL), a GABA(A) receptor partial agonist, were investigated on...

journal_title：Neuroscience letters

authors： Westh-Hansen SE,Noguchi K,Witt MR,Murai Y,Nielsen M,Akaike N

更新日期：1997-07-11 00:00:00

abstract：:People with Down syndrome develop Alzheimer's disease with an early age of onset. Plasma amyloid beta (Abeta) levels were measured in individuals with Down syndrome who were over the age of 40. No associations between age and Abeta1-40 and Abeta1-42 concentrations were found and nor were Abeta1-40 and Abeta1-42 levels...

journal_title：Neuroscience letters

authors： Jones EL,Hanney M,Francis PT,Ballard CG

更新日期：2009-02-20 00:00:00

abstract：:Cellular locations, axonal projections, and synaptic effects of inhibitory vestibulocollic (VC) neurons activated by the ampullary nerve of the posterior semicircular canal (PCN) were studied in anesthetized cats. The inhibitory VC neurons were identified by their monosynaptic responses to PCN stimulation and by their...

journal_title：Neuroscience letters

authors： Isu N,Sakuma A,Hiranuma K,Ichikawa T,Uchino Y

更新日期：1990-11-13 00:00:00