Changes in nicotinic acetylcholine receptor subunit mRNAs and nicotinic binding in spontaneously hypertensive stroke prone rats.

abstract：:Vasoactive intestinal polypeptide (VIP) in the concentration of 1 microM or less markedly and selectively increased the amplitude and duration of the muscarinic slow excitatory postsynaptic potential (EPSP) without appreciably affecting the nicotinic fast EPSP or the non-cholinergic EPSP of guinea pig inferior mesente...

journal_title：Neuroscience letters

authors： Mo N,Dun NJ

更新日期：1984-11-23 00:00:00

abstract：:Total RNA was purified from rat forebrain at different postnatal ages and analyzed by Northern blot using a specific neurotensin receptor RNA probe. The rat neurotensin receptor mRNA was present in high amount during the first 10 days of life. Thereafter, it rapidly decreased and was undetected after 20 days. [3H]neur...

journal_title：Neuroscience letters

authors： Hermans E,Jeanjean AP,Laduron PM,Octave JN,Maloteaux JM

更新日期：1993-07-09 00:00:00

abstract：:Delivery of alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionate receptors (AMPARs) to the synapse is a critical factor controlling synaptic strength. It is now established that blockade of synaptic activity increases the surface expression of AMPARs. Factors modulating the delivery, insertion and expression of AMPAR...

journal_title：Neuroscience letters

authors： Wang Y,Barbaro MF,Baraban SC

更新日期：2006-06-19 00:00:00

abstract：:A fundamental question in human sexuality regards the neural substrate underlying sexually-arousing representations. Lesion and neuroimaging studies suggest that dorsolateral pre-frontal cortex (DLPFC) plays an important role in regulating the processing of visual sexual stimulation. The aim of this Functional Near-In...

journal_title：Neuroscience letters

authors： Leon-Carrion J,Martín-Rodríguez JF,Damas-López J,Pourrezai K,Izzetoglu K,Barroso Y Martin JM,Dominguez-Morales MR

更新日期：2007-04-06 00:00:00

abstract：BACKGROUND:Perinatal hypoxic-ischemic insult is considered a major contributor to child mortality and morbidity and leads to neurological deficits in newborn infants. There has been a lack of promising neurotherapeutic interventions for hypoxic-ischemic brain damage (HIBD) for clinical application in infants. The prese...

journal_title：Neuroscience letters

authors： Zhu H,Qiao L,Sun Y,Yin L,Huang L,Jiang L,Li J

更新日期：2018-04-23 00:00:00

abstract：:We have investigated the effect of histamine (HA) on spontaneous firing of dopaminergic (DA) and GABAergic neurons in the substantia nigra (SN) and the ventral tegmental area (VTA) of the rat in vitro. Single-unit extracellular recordings were obtained and drugs were bath applied. In both regions application of HA (10...

journal_title：Neuroscience letters

authors： Korotkova TM,Haas HL,Brown RE

更新日期：2002-03-08 00:00:00

abstract：:This study examined the relationship of γ-aminobutyric acid (GABA) and glutamate levels from the anterior and posterior cingulates (AC and PC) with cerebral blood flow (CBF) at rest. (1)H magnetic resonance spectroscopy measurements in the AC and PC and pseudo-continuous arterial spin labeling data were acquired from ...

journal_title：Neuroscience letters

authors： Krause BW,Wijtenburg SA,Holcomb HH,Kochunov P,Wang DJ,Hong LE,Rowland LM

更新日期：2014-02-21 00:00:00

abstract：:Neural stem cells (NSCs) persist in the mammalian brain throughout life and protect against hypoxia-ischemia injury. NSCs are being increasingly recognized as a novel therapeutic target for various neurological disorders. Previous research indicates that miR-21 attenuates hypoxia-ischemia induced apoptotic death in va...

journal_title：Neuroscience letters

authors： Chen R,Tai Y,Zhang Y,Wang L,Yang Y,Yang N,Ma S,Xue F,Wang J

更新日期：2019-01-18 00:00:00

abstract：:Growing amounts of evidence suggest that N-Methyl-d-aspartate (NMDA) receptor mediated glutamate neurotransmission may be involved in the pathophysiology of drug dependence. The NMDA receptor consists of three subfamilies (NR1, NR2, and NR3). The ability of subunit NR3 to negatively modulate the NMDA receptor function...

journal_title：Neuroscience letters

authors： Xie X,Liu H,Zhang J,Chen W,Zhuang D,Duan S,Zhou W

更新日期：2016-09-19 00:00:00

abstract：:N-Methyl-D-aspartate (NMDA)-evoked release of [3H]acetylcholine (ACh) from slices of rat brain medial septum/vertical limb of the diagonal band (ms/vdB) was examined. NMDA increased the release of tritium in a concentration-dependent manner and the specific non-competitive NMDA antagonist, MK-801, and the competitive ...

journal_title：Neuroscience letters

authors： Nishimura LM,Boegman RJ

更新日期：1990-07-31 00:00:00

abstract：:A 12h sleep deprivation enhances the expression of 5-hydroxytryptamine (5-HT) 1A receptors in rat hippocampus that recedes with 48h sleep recovery. The depressant effect of applied 5-HT on the field excitatory postsynaptic potentials recorded in the CA1 area, is also enhanced in hippocampi of SD rats. Following a 24 o...

journal_title：Neuroscience letters

authors： Azizi H,Hwang J,Suen V,Kang NZ,Somvanshi R,Tadavarty R,Kumar U,Sastry BR

更新日期：2017-08-10 00:00:00

abstract：:CSF-A beta 42 may be a marker of Alzheimer's disease (AD). A decreased level of CSF-A beta 42 is consistently found in AD and has been suggested to be related to the deposition of amyloid plaques in the brain. However, low CSF-A beta 42 levels have also been found in disorders devoid of plaques, for instance Creutzfel...

journal_title：Neuroscience letters

authors： Sjögren M,Gisslén M,Vanmechelen E,Blennow K

更新日期：2001-11-13 00:00:00

abstract：:Parvalbumin-immunoreactive dystrophic neurites and aberrant terminal sprouts associated with senile plaques, together with preserved density of parvalbumin-immunoreactive neurons, were found in the cerebral cortex of two patients with Alzheimer's disease, one of them familiar, in which a biopsy of the left frontal lob...

journal_title：Neuroscience letters

authors： Ferrer I,Zújar MJ,Rivera R,Soria M,Vidal A,Casas R

更新日期：1993-08-20 00:00:00

abstract：:Using immunohistochemistry, Fas and caspase 8 positive sites were localized in the brains of Alzheimer patients and those with multiple infarcts as well as age-matched normal. The frontal, occipital and hippocampal regions were dissected out from these patients and normal individuals shortly after death. Positive Fas ...

journal_title：Neuroscience letters

authors： Yew DT,Ping Li W,Liu WK

更新日期：2004-08-26 00:00:00

abstract：:The goat milk contains conjugated linoleic acid (CLA), which can influence physical growth and brain development. This study investigated the impact of a diet containing goat milk fat (GMF) on physical parameters of gestating (G) and/or lactating (L) rat dams, and their progeny's physical growth, and anxiety behavior....

journal_title：Neuroscience letters

authors： Soares JK,de Melo AP,Medeiros MC,Queiroga RC,Bomfim MA,Santiago EC,Guedes RC

更新日期：2013-09-27 00:00:00

abstract：:The neuropathological hallmarks of Alzheimer's disease (AD) include the presence of extracellular amyloid-beta peptide (Abeta) in the form of amyloid plaques in the brain parenchyma and neuronal loss. The mechanism associated with neuronal death by amyloid plaques is unclear but oxidative stress and glial activation h...

journal_title：Neuroscience letters

authors： Lee HJ,Lee JK,Lee H,Shin JW,Carter JE,Sakamoto T,Jin HK,Bae JS

更新日期：2010-08-30 00:00:00

abstract：:Recently, we have reported that erythropoietin (Epo) provides neuroprotection in 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP)-induced neurotoxicity in vivo. In the present study, we investigated the effects of single Epo administration on brain antioxidant enzyme (superoxide dismutase (SOD) and glutathion perox...

journal_title：Neuroscience letters

authors： Genc S,Akhisaroglu M,Kuralay F,Genc K

更新日期：2002-03-15 00:00:00

abstract：:People with Down syndrome develop Alzheimer's disease with an early age of onset. Plasma amyloid beta (Abeta) levels were measured in individuals with Down syndrome who were over the age of 40. No associations between age and Abeta1-40 and Abeta1-42 concentrations were found and nor were Abeta1-40 and Abeta1-42 levels...

journal_title：Neuroscience letters

authors： Jones EL,Hanney M,Francis PT,Ballard CG

更新日期：2009-02-20 00:00:00

abstract：:Spatial memory is coordinated with different brain regions especially hippocampus (HIP) and medial prefrontal cortex (mPFC). Influence of noise stress on working and reference memory error in rats was evaluated by radial eight-arm maze experiment. Changes in the dendritic count were observed in the brain regions such ...

journal_title：Neuroscience letters

authors： Manikandan S,Padma MK,Srikumar R,Jeya Parthasarathy N,Muthuvel A,Sheela Devi R

更新日期：2006-05-15 00:00:00

abstract：:Normal aging is associated with chronic oxidative stress. In the basal ganglia, oxidative stress may contribute to the increased risk of Parkinson's disease in the elderly. Neurons are thought to actively utilize compensatory defense mechanisms, such as heat shock proteins (HSPs), to protect from persisting stress. De...

journal_title：Neuroscience letters

authors： Gupte AA,Morris JK,Zhang H,Bomhoff GL,Geiger PC,Stanford JA

更新日期：2010-03-19 00:00:00

abstract：:In this review, we summarize the recent development of positron emission tomography (PET) radioligands for γ-aminobutyric acid A (GABAA) receptors and their potential to measure changes in endogenous GABA levels and highlight the clinical and translational applications of GABA-sensitive PET radioligands. We review the...

journal_title：Neuroscience letters

authors： Andersson JD,Matuskey D,Finnema SJ

更新日期：2019-01-19 00:00:00

abstract：:Acute alcohol challenge suppresses the mismatch negativity (MMN) component of the auditory event-related potential (ERP), however, the transmitter systems underlying MMN generation/mediating this effect have remained vague. To test adenosinergic contribution, 12 healthy social drinkers participated in four sessions, i...

journal_title：Neuroscience letters

authors： Hirvonen J,Jääskeläinen IP,Näätänen R,Sillanaukee P

更新日期：2000-01-07 00:00:00

abstract：:To investigate a possible role of the lateral premotor cortex in human cognitive processes, we compared brain activity during mental-operation numeral (MO-numeral) and verbal rehearsal (VR) tasks, using block-design functional MRI. Sixteen healthy subjects serially added a series of single-digit numbers during the MO-...

journal_title：Neuroscience letters

authors： Hanakawa T,Honda M,Okada T,Fukuyama H,Shibasaki H

更新日期：2003-08-28 00:00:00

abstract：:The purpose of the study was to investigate the accuracy of location of equivalent current dipoles estimated by the dipole tracing method (DT) utilizing a realistic 3-shell (scalp-skull-brain) head model (SSB-DT). Three patients with intractable complex partial seizures, diagnosed as having typical temporal seizures w...

journal_title：Neuroscience letters

authors： Homma I,Masaoka Y,Hirasawa K,Yamane F,Hori T,Okamoto Y

更新日期：2001-05-18 00:00:00

abstract：:Central dopaminergic systems have been implicated in the regulation of blood pressure. We examined the effect on blood pressure of electrical or chemical stimulation of the rat brain ventral tegmental area (VTA) which is the region of origin of the A10 dopaminergic system. Electrical stimulation in urethane-anaestheti...

journal_title：Neuroscience letters

authors： Cornish JL,van den Buuse M

更新日期：1994-08-01 00:00:00

abstract：:To determine the relationship between cholinergic modulation within the rat medial prefrontal cortex (mPFC) and the progress of lever-press extinction, we conducted an experiment in which muscarinic and nicotinic acetylcholine (ACh) receptor antagonists were microinjected into the mPFC. The muscarinic antagonist injec...

journal_title：Neuroscience letters

authors： Maruki K,Izaki Y,Akema T,Nomura M

更新日期：2003-11-13 00:00:00

abstract：:The effect of chronic alcoholism in the neuronal nuclear area (karyometry) of the lateral entorhinal cortex at three rostro-caudal levels (rostral, intermediate and caudal) has been studied in 19 alcoholic subjects and in 15 aged-matched controls. Cases were distributed into three groups according to their age (29-44,...

journal_title：Neuroscience letters

authors： Ibáñez J,Herrero MT,Insausti R,Belzunegui T,Tuñón T,García-Bragado F,Gonzalo LM

更新日期：1995-01-02 00:00:00

abstract：:Cerebral ischemia-reperfusion (I/R)-induced brain tissue injury is a major obstacle for acute stroke management. Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) is reported to play a critical role in the regulation of myocardial or hepatic I/R injury. However, its role in cerebral I/R remains elu...

journal_title：Neuroscience letters

authors： Liu Y,Guo Y

更新日期：2021-01-19 00:00:00

abstract：:Oestrogen influences both oxytocin mRNA and peptide immunoreactivity in the preoptic area and the rat oxytocin gene contains functional oestrogen response elements. However, using combinations of immunocytochemistry and in situ hybridization for oxytocin and oestrogen receptor, we found that preoptic oxytocin neurons ...

journal_title：Neuroscience letters

authors： Cruttwell CJ,Herbison AE,Bicknell RJ

更新日期：1995-11-17 00:00:00

abstract：:Rat myotubes were cultured with embryonic mouse spinal cord explants. After 4 days of co-culture, (miniature) endplate potentials, (M)EPPs, could be detected in 20-40% of the nerve-contacted myotubes. Polyclonal antibodies against the neural cell adhesion molecule N-CAM and monoclonal antibodies to its L2/HNK-1 carboh...

journal_title：Neuroscience letters

authors： Mehrke G,Jockusch H,Schachner M

更新日期：1987-08-05 00:00:00