Abstract:
:Acute alcohol challenge suppresses the mismatch negativity (MMN) component of the auditory event-related potential (ERP), however, the transmitter systems underlying MMN generation/mediating this effect have remained vague. To test adenosinergic contribution, 12 healthy social drinkers participated in four sessions, ingesting: (1) placebo pill and placebo beverage; (2) caffeine (100 mg) and placebo beverage; (3) placebo pill and alcohol (0.55 g/kg in 10% (v/v) solution); or (4) both caffeine and alcohol. ERP measured during a dichotic-listening task disclosed increased MMN and P3b peak latencies, and diminished amplitude of processing negativity (PN) with alcohol, however, only the increase in MMN peak latency was significantly antagonized by caffeine. The results suggest that A1 and A2a receptors play a role in the generation of, and mediate partly the suppressant effect of ethanol on, the MMN.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Hirvonen J,Jääskeläinen IP,Näätänen R,Sillanaukee Pdoi
10.1016/s0304-3940(99)00897-6keywords:
subject
Has Abstractpub_date
2000-01-07 00:00:00pages
57-60issue
1-2eissn
0304-3940issn
1872-7972pii
S0304-3940(99)00897-6journal_volume
278pub_type
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