Adenosine A1/A2a receptors mediate suppression of mismatch negativity by ethanol in humans.

Abstract:

:Acute alcohol challenge suppresses the mismatch negativity (MMN) component of the auditory event-related potential (ERP), however, the transmitter systems underlying MMN generation/mediating this effect have remained vague. To test adenosinergic contribution, 12 healthy social drinkers participated in four sessions, ingesting: (1) placebo pill and placebo beverage; (2) caffeine (100 mg) and placebo beverage; (3) placebo pill and alcohol (0.55 g/kg in 10% (v/v) solution); or (4) both caffeine and alcohol. ERP measured during a dichotic-listening task disclosed increased MMN and P3b peak latencies, and diminished amplitude of processing negativity (PN) with alcohol, however, only the increase in MMN peak latency was significantly antagonized by caffeine. The results suggest that A1 and A2a receptors play a role in the generation of, and mediate partly the suppressant effect of ethanol on, the MMN.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Hirvonen J,Jääskeläinen IP,Näätänen R,Sillanaukee P

doi

10.1016/s0304-3940(99)00897-6

keywords:

subject

Has Abstract

pub_date

2000-01-07 00:00:00

pages

57-60

issue

1-2

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(99)00897-6

journal_volume

278

pub_type

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