Amyloid beta concentrations in older people with Down syndrome and dementia.

Abstract:

:People with Down syndrome develop Alzheimer's disease with an early age of onset. Plasma amyloid beta (Abeta) levels were measured in individuals with Down syndrome who were over the age of 40. No associations between age and Abeta1-40 and Abeta1-42 concentrations were found and nor were Abeta1-40 and Abeta1-42 levels found to vary between those with Alzheimer's-type dementia and those without dementia. The APOE genotype was not found to have an impact upon Abeta1-40 or Abeta1-42 concentrations. These data suggest that other factors play important roles in determining the onset and progression of dementia in the Down syndrome population.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Jones EL,Hanney M,Francis PT,Ballard CG

doi

10.1016/j.neulet.2008.12.030

subject

Has Abstract

pub_date

2009-02-20 00:00:00

pages

162-4

issue

2

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(08)01727-8

journal_volume

451

pub_type

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