Abstract:
:Total RNA was purified from rat forebrain at different postnatal ages and analyzed by Northern blot using a specific neurotensin receptor RNA probe. The rat neurotensin receptor mRNA was present in high amount during the first 10 days of life. Thereafter, it rapidly decreased and was undetected after 20 days. [3H]neurotensin binding experiments performed on the same tissues indicated that the total amount of neurotensin receptors increased during the first week and was maximal between day 7 and day 10. This plateau was followed by an important loss (70%) of neurotensin receptors. These results indicate that an important reduction in the genetic expression of the neurotensin receptor after day 10 may probably account for the [3H]neurotensin binding profile observed in rat forebrain during the postnatal ontogeny.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Hermans E,Jeanjean AP,Laduron PM,Octave JN,Maloteaux JMdoi
10.1016/0304-3940(93)90639-3subject
Has Abstractpub_date
1993-07-09 00:00:00pages
45-8issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(93)90639-3journal_volume
157pub_type
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