Postnatal ontogeny of the rat brain neurotensin receptor mRNA.

Abstract:

:Total RNA was purified from rat forebrain at different postnatal ages and analyzed by Northern blot using a specific neurotensin receptor RNA probe. The rat neurotensin receptor mRNA was present in high amount during the first 10 days of life. Thereafter, it rapidly decreased and was undetected after 20 days. [3H]neurotensin binding experiments performed on the same tissues indicated that the total amount of neurotensin receptors increased during the first week and was maximal between day 7 and day 10. This plateau was followed by an important loss (70%) of neurotensin receptors. These results indicate that an important reduction in the genetic expression of the neurotensin receptor after day 10 may probably account for the [3H]neurotensin binding profile observed in rat forebrain during the postnatal ontogeny.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Hermans E,Jeanjean AP,Laduron PM,Octave JN,Maloteaux JM

doi

10.1016/0304-3940(93)90639-3

subject

Has Abstract

pub_date

1993-07-09 00:00:00

pages

45-8

issue

1

eissn

0304-3940

issn

1872-7972

pii

0304-3940(93)90639-3

journal_volume

157

pub_type

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