Abstract：
:The p53 gene is mutated in pluripotential human neuroectodermal tumor DAOY cells which express both glial and neuronal markers. In most cells, nuclear m-p53 immunostaining was intense while cytoplasmic glial specific proteins (GSPs) were present at low levels. Conversely, glial fibrillary acidic protein (GFAP) and glutamine synthetase (GS) were expressed in the few cells devoid of nuclear m-p53 immunoreactivity. The level of neuron specific enolase (NSE) staining was low and not different between p53 positive and p53 negative cells. Therefore, a selective, mutually exclusive expression relationship exists between cytoplasmic GSPs and nuclear m-p53. Upon treatment with epidermal growth factor (EGF) and dibutyrylcyclic AMP, overall cytoplasmic GFAP and GS levels were increased while nuclear p53 was suppressed but a mutually exclusive expression pattern between these proteins was maintained. In cells which also express NSE, GFAP was selectively stimulated suggesting that nuclear expression of m-p53 and cytoplasmic expression of GSPs may be functionally related.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
U HS,Banaie A,Rigby L,Chen Jdoi
10.1016/s0304-3940(98)00061-5subject
Has Abstractpub_date
1998-03-06 00:00:00pages
41-6issue
1eissn
0304-3940issn
1872-7972pii
S0304394098000615journal_volume
244pub_type
杂志文章abstract：:Dibutyrylcytidine 3',5'-cyclic monophosphate (Bt2cCMP) stimulated neurite outgrowth in rat pheochromocytoma PC12 cells in a dose-dependent manner at the dose range from 0.5 mM to 6 mM. About 25% of the cells had neurites in response to 6 mM Bt2cCMP. In contrast with the effect of nerve growth factor (NGF) which increa...
journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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更新日期：2002-06-07 00:00:00
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journal_title：Neuroscience letters
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更新日期：2019-09-14 00:00:00
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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doi：10.1016/j.neulet.2011.06.045
更新日期：2011-08-18 00:00:00
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journal_title：Neuroscience letters
pub_type： 临床试验,杂志文章
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journal_title：Neuroscience letters
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更新日期：2006-05-22 00:00:00
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章
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journal_title：Neuroscience letters
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journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2005-02-28 00:00:00
