NMDA receptor dependent paroxysmal discharges in the dentate gyrus.

Abstract:

:The N-methyl-D-aspartic acid subclass of glutamate receptors is thought to be involved in events that depend on repetitive activation of neurons. The present study shows that repetitive stimulation of CA3 can produce epileptiform discharges in the contralateral dentate gyrus. This distinctive paroxysmal response was blocked by the NMDA antagonists, ketamine and MK-801. The MK-801 blockade required previous activation of the dentate gyrus in the presence of the drug, thus demonstrating, in vivo, a use-dependent effect. These studies show that repetitive, low intensity stimulation of hippocampal circuits can produce NMDA-mediated epileptiform discharges in the dentate gyrus.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Stringer JL,Lothman EW

doi

10.1016/0304-3940(88)90744-6

subject

Has Abstract

pub_date

1988-09-23 00:00:00

pages

69-75

issue

1

eissn

0304-3940

issn

1872-7972

pii

0304-3940(88)90744-6

journal_volume

92

pub_type

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