Abstract:
:The N-methyl-D-aspartic acid subclass of glutamate receptors is thought to be involved in events that depend on repetitive activation of neurons. The present study shows that repetitive stimulation of CA3 can produce epileptiform discharges in the contralateral dentate gyrus. This distinctive paroxysmal response was blocked by the NMDA antagonists, ketamine and MK-801. The MK-801 blockade required previous activation of the dentate gyrus in the presence of the drug, thus demonstrating, in vivo, a use-dependent effect. These studies show that repetitive, low intensity stimulation of hippocampal circuits can produce NMDA-mediated epileptiform discharges in the dentate gyrus.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Stringer JL,Lothman EWdoi
10.1016/0304-3940(88)90744-6subject
Has Abstractpub_date
1988-09-23 00:00:00pages
69-75issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(88)90744-6journal_volume
92pub_type
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