Abstract：
:Electrophysiological and biochemical studies have indicated that GABAergic modulation is involved in the opioid-induced altering of response properties of visual cortical cells and impairing of short-term synaptic plasticity in the geniculo-cortical visual pathway. The aim of the current study was to examine whether there were changes in the localization and density of micro-opioid receptor subtype (MOR1) and GABA in the visual cortex of morphine-dependent and abstinent rats. Immunofluorescence histochemical method was applied to display MOR1 and GABA distribution. We found that MOR1-like immunoreactive neurons were significantly lowered in layer I-VI of visual cortex of rats sacrificed immediately after the last injection (defined as morphine-dependent (MD)) than saline-control group. In rats sacrificed just before the last injection (defined as morphine-abstinent (MA)), the density of micro-opioid receptor was higher than that in dependent group in layer I-V neurons of visual cortex, but remained lower than those in control group. Three hours after the last morphine injection (defined as 3h after morphine-abstinent (3h)), MOR1-like immunoreactive neurons in layer I and layer IV of visual cortex were still significantly lower than control. As to GABA-like immunoreactive neurons, they were significantly decreased in abstinent group compared to dependent group. These results provide morphological evidence that opioid-induced altering of response properties of visual cortical cells might be due to the change of visual cortical GABAergic system induced by opioid via mu-opioid receptor, which result in disinhibition of visual cortex projection neurons and their abnormal firing.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Li Y,He L,Chen Q,Zhou Ydoi
10.1016/j.neulet.2007.09.041subject
Has Abstractpub_date
2007-11-20 00:00:00pages
11-6issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(07)01027-0journal_volume
428pub_type
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