Abstract:
:It is well known that acetyl-l-carnitine (ALC) has various neuroprotective effects against neurodegenerative diseases. In addition, it has been reported that ALC facilitates myelination of regenerated axons after peripheral nerve injuries. We previously reported that spontaneous regeneration of the lateral olfactory tract (LOT), the main fiber tract of the central olfactory system, consistently occurred in newborn rats and a majority of these regenerated fibers were unmyelinated in neonatally LOT-transected young adult rats. To investigate the effects of ALC treatment on myelination in LOT, neonatal rats were treated with ALC after LOT transection. Immunohistochemistry for myelin basic protein showed more positive areas in ALC-treated rats than in control rats. Moreover, the number of myelinated axons of regenerated fibers was assessed using electron microscopy and was found to be statistically higher in ALC-treated rats compared to control rats. The study revealed that ALC accelerates myelination of regenerated fibers in neonatally LOT-injured young adult rats.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Fukushima N,Yokouchi K,Kuroiwa M,Kawagishi K,Moriizumi Tdoi
10.1016/j.neulet.2017.06.001subject
Has Abstractpub_date
2017-07-13 00:00:00pages
215-219eissn
0304-3940issn
1872-7972pii
S0304-3940(17)30481-0journal_volume
653pub_type
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