Acetyl-l-carnitine enhances myelination of regenerated fibers of the lateral olfactory tract.

Abstract:

:It is well known that acetyl-l-carnitine (ALC) has various neuroprotective effects against neurodegenerative diseases. In addition, it has been reported that ALC facilitates myelination of regenerated axons after peripheral nerve injuries. We previously reported that spontaneous regeneration of the lateral olfactory tract (LOT), the main fiber tract of the central olfactory system, consistently occurred in newborn rats and a majority of these regenerated fibers were unmyelinated in neonatally LOT-transected young adult rats. To investigate the effects of ALC treatment on myelination in LOT, neonatal rats were treated with ALC after LOT transection. Immunohistochemistry for myelin basic protein showed more positive areas in ALC-treated rats than in control rats. Moreover, the number of myelinated axons of regenerated fibers was assessed using electron microscopy and was found to be statistically higher in ALC-treated rats compared to control rats. The study revealed that ALC accelerates myelination of regenerated fibers in neonatally LOT-injured young adult rats.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Fukushima N,Yokouchi K,Kuroiwa M,Kawagishi K,Moriizumi T

doi

10.1016/j.neulet.2017.06.001

subject

Has Abstract

pub_date

2017-07-13 00:00:00

pages

215-219

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(17)30481-0

journal_volume

653

pub_type

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