Increase of plasma neuropeptide Y-like immunoreactivity following chronic hypoxia in the rat.

abstract：:Sensitisation of the capsaicin receptor, transient receptor potential vanilloid type 1 (TRPV1) ion channel in nociceptive primary sensory neurons (PSN) underlies the development of inflammatory heat hyperalgesia. Removal of the negative-dominant splice variant of the TRPV1 molecule, TRPV1b from TRPV1/TRPV1b heterotetr...

journal_title：Neuroscience letters

authors： Mistry S,Paule CC,Varga A,Photiou A,Jenes A,Avelino A,Buluwela L,Nagy I

更新日期：2014-04-03 00:00:00

abstract：:Vitamin B12 is implicated in methylation processes. Myelin basic protein is methylated on one arginine group. A defect in methylation could produce an unstable protein, leading to neurological disorders. In order to study myelin basic protein, we have developed the cultures of newborn rat oligodendrocytes in vitamin B...

journal_title：Neuroscience letters

authors： Sponne IE,Gaire D,Stabler SP,Droesch S,Barbé FM,Allen RH,Lambert DA,Nicolas JP

更新日期：2000-07-21 00:00:00

abstract：:DNA methylation of a CpG island located in intron 1 of the α-synuclein gene (SNCA) has been reported to play an essential role in the regulation of α-synuclein transcription, and probably has a close association with Parkinson's disease (PD). However, there is no simple and cost effective method to quantify DNA methyl...

journal_title：Neuroscience letters

authors： Song Y,Ding H,Yang J,Lin Q,Xue J,Zhang Y,Chan P,Cai Y

更新日期：2014-05-21 00:00:00

abstract：:Erythropoietin (EPO) and its specific receptor (EPOR) have been proposed to act as an endogenous system protecting against neuronal injury and neurodegeneration. We measured EPO in cerebrospinal fluid (CSF) of patients with neurodegenerative diseases, and tested for a correlation with an established biomarker of neuro...

journal_title：Neuroscience letters

authors： Brettschneider J,Widl K,Ehrenreich H,Riepe M,Tumani H

更新日期：2006-09-01 00:00:00

abstract：:The aim of the present study was to investigate the intrathecal (i.t.) action of a selective A1-adenosine receptor agonist, R-phenylisopropyl adenosine (R-PIA), on tactile withdrawal thresholds in a rat model of mononeuropathy produced by sciatic chronic constriction injury (CCI). An additional aim was to examine whet...

journal_title：Neuroscience letters

authors： Cui JG,Sollevi A,Linderoth B,Meyerson BA

更新日期：1997-02-28 00:00:00

abstract：:Gabaculine, a conformationally restricted analogue of GABA, is (i) a moderately potent inhibitor (IC(50) 69 muM) of the sodium-dependent uptake of GABA in rat brain slices, (ii) ineffective at 100 muM as an inhibitor of the sodium-independent binding of GABA to membranes from rat brain, (iii) a relatively weak inhibit...

journal_title：Neuroscience letters

authors： Allan RD,Johnston GA,Twitchin B

更新日期：1977-01-01 00:00:00

abstract：:In order to study the mechanism of intracellular sorting and processing of the Alzheimer's disease amyloid precursor protein (APP), we deleted two potential N-linked glycosylation sites of APP by site-directed mutagenesis. Substitution of alanines for the critical asparagine residues Asn467 and Asn496 was performed. W...

journal_title：Neuroscience letters

authors： Yazaki M,Tagawa K,Maruyama K,Sorimachi H,Tsuchiya T,Ishiura S,Suzuki K

更新日期：1996-12-27 00:00:00

abstract：:Interleukin-1 beta (IL-1 beta), interleukin-2 (IL-2), and interleukin-6 (IL-6) were measured in the cerebrospinal fluid (CSF) and plasma of 12 control subjects, 11 sporadic Alzheimer's disease (AD) and 22 de novo Parkinson's disease (PD) patients using high sensitivity enzyme-linked immunosorbent assays (ELISA). IL-1 ...

journal_title：Neuroscience letters

authors： Blum-Degen D,Müller T,Kuhn W,Gerlach M,Przuntek H,Riederer P

更新日期：1995-12-29 00:00:00

abstract：:The possibility that zinc (Zn2+) induces giant depolarizing potentials (GDPs) by blocking pre- and postsynaptic gamma-aminobutyric acidB (GABAB) receptors in area CA1 of rat hippocampal slices was investigated. Monosynaptic GABAA receptor-mediated fast and GABAB receptor-mediated late inhibitory postsynaptic potential...

journal_title：Neuroscience letters

authors： Lambert NA,Levitin M,Harrison NL

更新日期：1992-02-03 00:00:00

abstract：:The influence of insulin on the infarct volume due to middle cerebral artery (MCA) occlusion was investigated in rats. A small dose of insulin (1 unit/kg) was injected i.p. just after MCA occlusion. The infarct areas were measured by planimetry from brains perfused with 2,3,5-triphenyltetrazolium-chloride (TTC) 48 h a...

journal_title：Neuroscience letters

authors： Izumi Y,Pinard E,Roussel S,Seylaz J

更新日期：1992-09-14 00:00:00

abstract：:Mutations in the glucocerebrosidase (GCase) gene (GBA) and GCase deficiency are major risk factors for Lewy body diseases. Decreased GCase activity enhances alpha-synuclein aggregation and disease development. Lysosomal integral membrane protein type 2, encoded by SCARB2, binds GCase targeting it to lysosomes and tran...

journal_title：Neuroscience letters

authors： Pérez-Roca L,Prada-Dacasa P,Segú-Vergés C,Gámez-Valero A,Serrano-Muñoz MA,Santos C,Beyer K

更新日期：2019-07-27 00:00:00

abstract：:Aphasia is a highly disabling language disorder usually caused by a left stroke brain damage. Even if traditional language therapies have been proved to induce an adequate clinical recovery, a large percentage of patients are left with chronic deficits at 6 months post-stroke. Therefore, new strategies to common speec...

journal_title：Neuroscience letters

authors： Marangolo P

更新日期：2020-02-06 00:00:00

abstract：:Transient cognitive and behavioral stabilization of patients with Alzheimer's disease (AD) is the main goal of acetylcholinesterase inhibitor (AChEI) therapy. Response to treatment is variable and it is usually assessed clinically via neuropsychological scales. Functional neuroimaging could ideally permit the objectiv...

journal_title：Neuroscience letters

authors： Ferreri F,Pasqualetti P,Määttä S,Ponzo D,Guerra A,Bressi F,Chiovenda P,Del Duca M,Giambattistelli F,Ursini F,Tombini M,Vernieri F,Rossini PM

更新日期：2011-04-01 00:00:00

abstract：:In a light microscopic study the ferric ion-ferrocyanide staining of the squid giant axon was investigated. In other neurons this stain is known to indicate excitable membranes with high sodium channel density, such as the node of Ranvier or the initial segment. In the squid the stain reacted in small patches of the a...

journal_title：Neuroscience letters

authors： Greeff NG,Akert K,Sandri C

更新日期：1985-06-12 00:00:00

abstract：:The facial nucleus (FN) has been known as a motor nucleus to control the activity of the facial skeletal muscles by its efferent somatic motoneurons. Much less, however, is known about the non-motor control functions of its interneurons. The present study was designed to investigate if the interneurons of the FN parti...

journal_title：Neuroscience letters

authors： Zhang C,Yan H,Li C,Zheng Y

更新日期：2004-09-09 00:00:00

abstract：:The dopamine transporter (DAT1) gene has been implicated in the pathogenesis of many neuropsychiatric disorders, including schizophrenia. The present study aimed to investigate association of the DAT1 gene polymorphisms with schizophrenia in a Han Chinese population. Two single nucleotide polymorphisms (SNPs) in the D...

journal_title：Neuroscience letters

authors： Zheng C,Shen Y,Xu Q

更新日期：2012-04-04 00:00:00

abstract：:We have investigated the effect of ethanol upon vasopressin (AVP) content in brain and upon in-vitro release of AVP from the rat median eminence. In-vitro ethanol concentrations (5-25 mM), comparable to behaviorally relevant blood ethanol levels, induce a substantial inhibition of AVP release from the median eminence,...

journal_title：Neuroscience letters

authors： Brinton RE,Gruener R,Deshmukh P,Yamamura HI

更新日期：1986-06-18 00:00:00

abstract：:Extracellular field-potential recordings and measurements of the extracellular concentration of potassium ([K+]o) were made in layers II and III of the adult rat entorhinal cortex in a slice preparation. Two types of spontaneous, synchronous potentials were induced by the convulsant drug 4-aminopyridine (4AP, 50 micro...

journal_title：Neuroscience letters

authors： Lücke A,Nagao T,Köhling R,Avoli M

更新日期：1995-02-13 00:00:00

abstract：:Somatosensory evoked potentials to median nerve (MN) stimulation were recorded by stereotactically implanted electrodes in the frontal lobe of two epileptic patients in order to evaluate whether short-latency cortical responses could be generated in the supplementary motor area (SMA)-proper. In both patients two poten...

journal_title：Neuroscience letters

authors： Barba C,Valeriani M,Restuccia D,Colicchio G,Faraca G,Tonali P,Mauguière F

更新日期：2003-07-03 00:00:00

abstract：:In previous studies, chronic low-dose methylphenidate (MPH) administration during early development has been shown to increase emotional responding in adulthood. However, most studies employed male subjects, which generally show enhanced fear relative to females in laboratory tests of anxious behaviors. The present st...

journal_title：Neuroscience letters

authors： Bethancourt JA,Vásquez CE,Britton GB

更新日期：2011-05-27 00:00:00

abstract：:Previous research has revealed the existence of perceptual mechanisms that compensate for slight temporal asynchronies between auditory and visual signals. We investigated whether temporal recalibration would also occur between auditory and tactile stimuli. Participants were exposed to streams of brief auditory and ta...

journal_title：Neuroscience letters

authors： Navarra J,Soto-Faraco S,Spence C

更新日期：2007-02-08 00:00:00

abstract：:The circadian modulation of occurrence of non-rapid-eye-movement sleep (NREM) was investigated in 37 volunteers under dim-light conditions after 24-h total sleep deprivation using a 26-h 10/20-min ultra-short sleep-wake schedule. The propensity of NREM showed rapid increase followed by gradual decrease during the subj...

journal_title：Neuroscience letters

authors： Tagaya H,Uchiyama M,Shibui K,Kim K,Suzuki H,Kamei Y,Okawa M

更新日期：2002-04-19 00:00:00

abstract：:Parvalbumin-immunoreactive dystrophic neurites and aberrant terminal sprouts associated with senile plaques, together with preserved density of parvalbumin-immunoreactive neurons, were found in the cerebral cortex of two patients with Alzheimer's disease, one of them familiar, in which a biopsy of the left frontal lob...

journal_title：Neuroscience letters

authors： Ferrer I,Zújar MJ,Rivera R,Soria M,Vidal A,Casas R

更新日期：1993-08-20 00:00:00

abstract：:The first psychotic episode is classically viewed as a critical period which management is important in determining the long-term outcome of the schizophrenia (SCZ). For this reason, the duration of untreated illness (DUI), defined as the interval between the onset of the psychiatric disorder and the administration of...

journal_title：Neuroscience letters

authors： Murru A,Carpiniello B

更新日期：2018-03-16 00:00:00

abstract：:Lesion-induced degeneration was combined with immunocytochemistry to study, with electron microscopy, the synaptic connectivity between corticothalamic axon terminals from the first and second somatosensory areas and local circuit neurons of the ipsilateral ventrobasal complex (VB), selectively labelled with an antibo...

journal_title：Neuroscience letters

authors： Barbaresi P,Manzoni T

更新日期：2003-03-27 00:00:00

abstract：:Reactive oxygen species (ROS), such as superoxide and hydrogen peroxide, play essential roles in physiological plasticity and are also involved in the pathogenesis of persistent pain. Roles of peripheral and spinal ROS in pain have been well established, but much less is known about ROS in the amygdala, a brain region...

journal_title：Neuroscience letters

authors： Lu YF,Neugebauer V,Chen J,Li Z

更新日期：2016-04-21 00:00:00

abstract：OBJECTIVES:Suicide attempt in schizophrenia is an important clinical issue. We performed a genome-wide association study to identify genetic markers, which increase the risk for suicide attempt in schizophrenia. METHODS:Suicide attempt lifetime was assessed in 121 schizophrenia patients and defined by the means of the...

journal_title：Neuroscience letters

authors： Bani-Fatemi A,Graff A,Zai C,Strauss J,De Luca V

更新日期：2016-05-27 00:00:00

abstract：:kappa-Opioid receptors were radiolabelled with the peptides [125I]dynorphin(1-8) and [3H]dynorphin(1-8) or with [3H]etorphine on guinea pig forebrain and cerebellar sections and visualized by quantitative autoradiography. All three radioligands yielded similar patterns of kappa-receptor localization. However, quantita...

journal_title：Neuroscience letters

authors： Sharif NA,Hunter JC,Hill RG,Hughes J

更新日期：1988-04-12 00:00:00

abstract：:The effects of administration of 1-oleoyl-2-docosahexaenoyl-sn-glycero-3-phosphorylcholine (O-DH-PC), a kind of lecithin, and of glycerophosphorylcholine (GPC) on sleep were investigated in male F344 rats. Intracerebroventricular administration of O-DH-PC at a dose of 10 micrograms/rat induced significant increase in ...

journal_title：Neuroscience letters

authors： Hashimoto M,Gong XW,Izaki Y,Iriki M,Hibino H

更新日期：1993-08-06 00:00:00

abstract：:Neuropeptide Y (NPY)-immunoreactivity has been localized to a rich network of fibres in the uvea of guinea pig and rat. In the iris, NPY-immunoreactive nerves were present in iridial smooth muscle and around blood vessels; similarly throughout the choroid a dense network of NPY-immunoreactive fibres was found surround...

journal_title：Neuroscience letters

authors： Terenghi G,Polak JM,Allen JM,Zhang SQ,Unger WG,Bloom SR

更新日期：1983-11-21 00:00:00