Prolonged exposure to bradykinin and prostaglandin E2 increases TRPV1 mRNA but does not alter TRPV1 and TRPV1b protein expression in cultured rat primary sensory neurons.

abstract：:Traumatic brain injury (TBI) is a major cause of neurological disability across all ages, but the elderly are particularly vulnerable and have a worse prognosis than younger individuals. To advance the understanding of long-term pathogenesis induced by TBI in the elderly, aged mice (21 -- 24 months) were given a contr...

journal_title：Neuroscience letters

authors： Onyszchuk G,LeVine SM,Brooks WM,Berman NE

更新日期：2009-03-13 00:00:00

abstract：:The mechanisms responsible for the termination of paroxysmal depolarization shifts (PDS) were studied with intracellular recordings on CA1 neurons of rat hippocampal slices. Epileptiform activity was induced by application of penicillin, bicuculline or Mg-free artificial cerebrospinal fluid (ACSF). PDS in penicillin-c...

journal_title：Neuroscience letters

authors： Domann R,Westerhoff CH,Witte OW

更新日期：1994-07-18 00:00:00

abstract：:The present study was designed to test the hypothesis that administration of low extracellular levels of magnesium ions ([Mg(2+)](o)) to primary cultured cerebral vascular smooth muscle cells will cause lipid peroxidation, degradation of IkappaB-alpha, and activation of nuclear transcription factor kappa B (NF-kappaB)...

journal_title：Neuroscience letters

authors： Altura BM,Gebrewold A,Zhang A,Altura BT

更新日期：2003-05-08 00:00:00

abstract：:The effects of histamine (HA) on the resting membrane potential and input resistance of rat medial vestibular nucleus (MVN) neurons were investigated using intracellular recording techniques from a submerged brain slice preparation. The exogenous application of HA predominantly produced a concentration-dependent membr...

journal_title：Neuroscience letters

authors： Phelan KD,Nakamura J,Gallagher JP

更新日期：1990-02-16 00:00:00

abstract：:Aquaporins are involved in the maintenance of ionic and osmotic balance in the central nervous system and in the eye. Whereas the expression of aquaporin-9 immunoreactivity in the brain has been described for catecholaminergic neurons and glial cells, the expression of aquaporin-9 in the neural retina is unclear. We e...

journal_title：Neuroscience letters

authors： Iandiev I,Biedermann B,Reichenbach A,Wiedemann P,Bringmann A

更新日期：2006-05-08 00:00:00

abstract：:The AMPA receptor subunit GluR2 is downregulated in neurons following a wide range of neurological insults. Here we report that suppression of GluR2 gene promoter activity is associated with kainate (KA)-induced downregulation of GluR2 subunit levels in primary cultured cortical neurons. RT-PCR and Northern blotting s...

journal_title：Neuroscience letters

authors： Jia YH,Zhu X,Li SY,Ni JH,Jia HT

更新日期：2006-07-31 00:00:00

abstract：:During hibernation the body temperature of the golden-mantled ground squirrel, Spermophilus lateralis, may drop below 5 degrees C for a few hours to a week or more. Animals cycle between euthermia and deep hibernation many times over the course of the hibernation season. Expression of the transcription factor c-fos in...

journal_title：Neuroscience letters

authors： Bitting L,Sutin EL,Watson FL,Leard LE,O'Hara BF,Heller HC,Kilduff TS

更新日期：1994-01-03 00:00:00

abstract：:The aim of the present study was to assess reorganization in the motor cortex of patients with lower limb amputation. We studied seven patients with traumatic lower limb amputation, and six healthy controls, using transcranial magnetic stimulation mapping, with recordings from the quadriceps femoris muscle on both sid...

journal_title：Neuroscience letters

authors： Schwenkreis P,Pleger B,Cornelius B,Weyen U,Dertwinkel R,Zenz M,Malin JP,Tegenthoff M

更新日期：2003-10-09 00:00:00

abstract：:Xenopus oocytes were coinjected with cDNAs encoding the Drosophila melanogaster metabotropic glutamate receptor (DmGluRA) and two mammalian G-protein inwardly rectifying potassium channel subunits (GIRK1 and GIRK2). Glutamate and two vertebrate group II mGluR agonists (order of potency: LY 354740 > glutamate > DCG IV)...

journal_title：Neuroscience letters

authors： Raymond V,Hamon A,Grau Y,Lapied B

更新日期：1999-07-02 00:00:00

abstract：:NGP1-01, a member of the pentacycloundecylamine cage compound family, was recently shown to exhibit both NMDA receptor channel blocking and L-type calcium channel antagonism activity. In the present study, focal ischemia was induced in mice by permanent middle cerebral artery occlusion (MCAO) to test for potential neu...

journal_title：Neuroscience letters

authors： Mdzinarishvili A,Geldenhuys WJ,Abbruscato TJ,Bickel U,Klein J,Van der Schyf CJ

更新日期：2005-07-22 00:00:00

abstract：:The present study has described and quantitated the distribution of mu-opioid receptors in the nucleus raphe magnus (NRM) and nucleus gigantocellularis (NGC), using in vitro autoradiography. Moderately dense binding of a mu-enkephalin analog, DAGO, was observed in the NRM and adjacent parts of the NGC. DAGO binding de...

journal_title：Neuroscience letters

authors： Bowker RM,Dilts RP

更新日期：1988-06-07 00:00:00

abstract：:The cloned vanilloid receptor-1 (VR1) is recognized as a common molecular target for protons, noxious heat, and vanilloids. The presence of VR1 in the dorsal root, trigeminal, and nodose ganglia has been firmly established, but it is unclear in the gut, despite this VR1 may be important for gastric mucosal homeostasis...

journal_title：Neuroscience letters

authors： Nozawa Y,Nishihara K,Yamamoto A,Nakano M,Ajioka H,Matsuura N

更新日期：2001-08-17 00:00:00

abstract：:Neuroimaging studies have identified frontal lobe brain abnormalities in migraineurs. Neuropsychological investigations highlighted frontal lobe related cognitive impairments in migraineurs, including working memory and executive function deficits. The relationship between brain anatomy and cognitive function in migra...

journal_title：Neuroscience letters

authors： Schmitz N,Arkink EB,Mulder M,Rubia K,Admiraal-Behloul F,Schoonman GG,Kruit MC,Ferrari MD,van Buchem MA

更新日期：2008-08-01 00:00:00

abstract：:We report positron emission tomographic measurements of regional cerebral blood flow (rCBF) in a male patient with war and torture related post-traumatic stress disorder (PTSD) during symptom provocation. The subject was exposed to war related sounds before and after treatment with a selective serotonin reuptake inhib...

journal_title：Neuroscience letters

authors： Fernandez M,Pissiota A,Frans O,von Knorring L,Fischer H,Fredrikson M

更新日期：2001-01-12 00:00:00

abstract：:People with Down syndrome develop Alzheimer's disease with an early age of onset. Plasma amyloid beta (Abeta) levels were measured in individuals with Down syndrome who were over the age of 40. No associations between age and Abeta1-40 and Abeta1-42 concentrations were found and nor were Abeta1-40 and Abeta1-42 levels...

journal_title：Neuroscience letters

authors： Jones EL,Hanney M,Francis PT,Ballard CG

更新日期：2009-02-20 00:00:00

abstract：:Pituitary adenylate cyclase-activating polypeptide-like immunoreactive (PACAP-LI) neuronal elements in the rat hypothalamus including the median eminence (ME) were investigated by light and electron microscopic immunocytochemistry. PACAP-LI neuronal perikarya with well-developed cell organelles and dense granules were...

journal_title：Neuroscience letters

authors： Tamada Y,Tanaka M,Ichitani Y,Okamura H,Yanaihara N,Ibata Y

更新日期：1994-10-24 00:00:00

abstract：:Coenzyme Q(10) (CoQ(10)) exerts neuroprotective effects in several in vivo and in vitro models of neurodegenerative disorders. However, the mechanisms of action are not fully understood. The aim in this study was to investigate whether oral administration of CoQ(10) could inhibit cytochrome c (cyt c) release from mito...

journal_title：Neuroscience letters

authors： Mitsumoto Y,Kobayashi S,Matsushima H,Muroyama A,Yoshimura I

更新日期：2009-09-29 00:00:00

abstract：:The induction of heme oxygenase-1 (HO-1), the 32 kDa heat shock protein, was examined in the traumatized rat brain. At 24 h after either mild or severe brain injury or sham surgery, HO-1 was immunolocalized in fixed sections of brain. After mild brain injury, hemorrhage was apparent in the subarachnoid space, external...

journal_title：Neuroscience letters

authors： Fukuda K,Panter SS,Sharp FR,Noble LJ

更新日期：1995-10-20 00:00:00

abstract：:The ultrastructure of astrocytic foot processes at the glia limitans in rat optic nerve was studied by freeze-fracture. Two classes of astrocytic end-foot processes were observed. Most astrocytic foot processes in this region show a high density of orthogonal arrays of P-face particles (assemblies) that are randomly o...

journal_title：Neuroscience letters

authors： Black JA,Waxman SG

更新日期：1985-04-19 00:00:00

abstract：:Neuronal apoptosis is a contributing cause of disability and death in cerebral ischemia. Nuclear factor-κB (NF-κB) may become a potential therapeutic target for hypoxic/ischemic neuron damage because NF-κB is inactivated after hypoxia exposure. Vascular endothelial growth factor (VEGF) has been found to improve neurol...

journal_title：Neuroscience letters

authors： Mo SJ,Hong J,Chen X,Han F,Ni Y,Zheng Y,Liu JQ,Xu L,Li Q,Yang XH,Sun RH,Yin XY

更新日期：2016-01-01 00:00:00

abstract：:Neuronal voltage-dependent P/Q Ca2+ channels are genetically abnormal in many cases of familial hemiplegic migraine and possibly associated with the more common forms of migraine with and without aura. Besides the brain, these channels are found in motor nerve endings where they control stimulation-induced acetylcholi...

journal_title：Neuroscience letters

authors： Ambrosini A,de Noordhout AM,Alagona G,Dalpozzo F,Schoenen J

更新日期：1999-12-10 00:00:00

abstract：:Telmisartan is an angiotensin II type 1 receptor blocker and partial agonist of peroxisome proliferator-activated receptor gamma (PPAR-γ). Here, we investigated the protective capacity of telmisartan against high glucose (HG)-elicited oxidative damage in PC12 cells. The activity of lactate dehydrogenase (LDH), NADPH o...

journal_title：Neuroscience letters

authors： Eslami H,Sharifi AM,Rahimi H,Rahati M

更新日期：2014-01-13 00:00:00

abstract：:The input-output relation of a single neuron stands at the basis of every biologically oriented description of the brain. This report shows that the input-output relation of cultured cortical neurons is non-linearly tuned by the input frequency. Increasing the rate of stimulation results in the appearance of ordered t...

journal_title：Neuroscience letters

authors： Tal D,Jacobson E,Lyakhov V,Marom S

更新日期：2001-03-02 00:00:00

abstract：:Secondary optic projections were studied in the toad, Bufo marinus using the method of transneuronal transport of triated proline and fucose. Following a survival of 14 days after eye injection autoradiographic label was transported transneuronally to the contralateral nucleus isthmi, the deeper layers of the contrala...

journal_title：Neuroscience letters

authors： Mayner L

更新日期：1980-03-01 00:00:00

abstract：:Transforming growth factor-β (TGF-β) is an anti-inflammatory cytokine and is expressed in the injured spinal cord. TGF-β signals through receptors to activate Smad proteins, which translocate into the nucleus. In the present study, we investigated the chronological alterations and cellular locations of the TGF-β/Smad ...

journal_title：Neuroscience letters

authors： Joko M,Osuka K,Usuda N,Atsuzawa K,Aoyama M,Takayasu M

更新日期：2013-08-09 00:00:00

abstract：:Bereitschaftspotentials (BPs) preceding muscle relaxation and contraction were compared by using subdural electrodes which were implanted onto the right medial frontal surface in two patients with supplementary motor area (SMA) seizure. The applied movement paradigm (muscle relaxation and contraction tasks) was comple...

journal_title：Neuroscience letters

authors： Yazawa S,Ikeda A,Kunieda T,Mima T,Nagamine T,Ohara S,Terada K,Taki W,Kimura J,Shibasaki H

更新日期：1998-03-20 00:00:00

abstract：:Motor and sensory neuropathies with the clinical features of HMSN III (Dejerine-Sottas syndrome, DSS) are etiologically related to heterozygous mutations in either peripheral myelin protein-22 (PMP22) or myelin protein zero (MPZ). Heterozygous mutations in either of these two genes are also responsible for other hered...

journal_title：Neuroscience letters

authors： Stögbauer F,Young P,Wiebusch H,Timmerman V,Kuhlenbäumer G,Nelis E,Ringelstein EB,Kurlemann G,Assmann G,Van Broeckhoven C,Funke H

更新日期：1998-01-02 00:00:00

abstract：:The involvement of ecto-protein kinase activity in activity-dependent long-term potentiation (LTP) was studied in CA1 neurons of guinea-pig hippocampal slices. Application of 5 microM K-252b, an ecto-protein kinase inhibitor, blocked LTP induced by a theta-burst stimulation (3 bursts composed of 5 pulses at 100 Hz wit...

journal_title：Neuroscience letters

authors： Fujii S,Ito K,Osada H,Hamaguchi T,Kuroda Y,Kato H

更新日期：1995-03-03 00:00:00

abstract：:Mutations in coding exons or exon 10 5'-splice-site of the gene for microtubule-associated protein tau can cause chromosome 17-linked frontotemporal dementia and parkinsonism (FTDP-17). We sequenced the 11 coding exons plus exon-intron boundaries of the tau gene in 15 cases of progressive supranuclear palsy (PSP), and...

journal_title：Neuroscience letters

authors： Bonifati V,Joosse M,Nicholl DJ,Vanacore N,Bennett P,Rizzu P,Fabbrini G,Marconi R,Colosimo C,Locuratolo N,Stocchi F,Bonuccelli U,De Mari M,Wenning G,Vieregge P,Oostra B,Meco G,Heutink P

更新日期：1999-10-15 00:00:00

abstract：:Histone modifications, such as lysine methylation, acetylation and ubiquitination, are epigenetic tags that shape the chromatin landscape and regulate transcription required for synaptic plasticity and memory. Here, we show that transcription-promoting histone H3 trimethylated at lysine 4 (H3K4me3), histone H3 acetyla...

journal_title：Neuroscience letters

authors： Bach SV,Tacon PR,Morgan JW,Hegde AN

更新日期：2015-03-30 00:00:00