Abstract:
:Xenopus oocytes were coinjected with cDNAs encoding the Drosophila melanogaster metabotropic glutamate receptor (DmGluRA) and two mammalian G-protein inwardly rectifying potassium channel subunits (GIRK1 and GIRK2). Glutamate and two vertebrate group II mGluR agonists (order of potency: LY 354740 > glutamate > DCG IV) elicited inwardly rectifying potassium currents. These inward currents were sensitive to cesium and barium. They were also blocked by two group II specific antagonists MCCG and APICA (IC50s 97.5 and 200 microM, respectively) and not affected by a group I antagonist (AIDA). Finally, the A-protomer of PTX reduced the glutamate-induced GIRK currents. This study is the first characterization of an invertebrate mGluR-mediated GIRK currents via a PTX-sensitive G protein.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Raymond V,Hamon A,Grau Y,Lapied Bdoi
10.1016/s0304-3940(99)00294-3keywords:
subject
Has Abstractpub_date
1999-07-02 00:00:00pages
1-4issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(99)00294-3journal_volume
269pub_type
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