Brain function in a patient with torture related post-traumatic stress disorder before and after fluoxetine treatment: a positron emission tomography provocation study.

Abstract:

:We report positron emission tomographic measurements of regional cerebral blood flow (rCBF) in a male patient with war and torture related post-traumatic stress disorder (PTSD) during symptom provocation. The subject was exposed to war related sounds before and after treatment with a selective serotonin reuptake inhibitor (SSRI; Fluoxetine; Fontex((R))). Therapy reduced PTSD symptoms, provoked anxiety and heart rate. Before treatment trauma reminders resulted in decreased rCBF in the insula, prefrontal, and inferior frontal cortices. Increased activity was evident in the cerebellum, precuneus and supplementary motor cortex. This was normalized after SSRI administration. Prefrontal and cingulate rCBF correlated with heart rate. Hence, the anxiolytic effect of SSRI for PTSD could be mediated by prefrontal and paralimbic cortices. Data suggest that SSRI treatment normalize provocation induced rCBF alterations in areas involved in memory, emotion, attention and motor-control.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Fernandez M,Pissiota A,Frans O,von Knorring L,Fischer H,Fredrikson M

doi

10.1016/s0304-3940(00)01674-8

keywords:

subject

Has Abstract

pub_date

2001-01-12 00:00:00

pages

101-4

issue

2

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(00)01674-8

journal_volume

297

pub_type

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