Tangential synaptic distribution of NMDA and AMPA receptors in rat neocortex.

Abstract:

:We performed an electron microscopic study in layers II-III of S-1 in rats, using postembedding immunogold histochemistry to compare the synaptic distribution of N-methyl D-aspartate (NMDA) receptors (assessed with an antibody for the NMDAR1 subunit) with that of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors (assessed with an antibody for the GluR2/3 subunit). Labeling for each receptor was concentrated at active zones of asymmetric synapses. Analysis of the tangential position of gold particles along the postsynaptic active zone revealed that NMDA receptors were at highest concentration in the middle of the synaptic apposition, whereas AMPA receptors were concentrated in an annulus away from its center. These data support the view that the two types of receptors are anchored by distinct subsynaptic assemblies, and raise the possibility of independent synaptic microdomains.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Kharazia VN,Weinberg RJ

doi

10.1016/s0304-3940(97)00846-x

subject

Has Abstract

pub_date

1997-11-28 00:00:00

pages

41-4

issue

1-2

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(97)00846-X

journal_volume

238

pub_type

杂志文章
  • Hypertrophy of neurons in the inferior olive after cerebellar ablations in the cat.

    abstract::Olivary hypertrophy, a combined retrograde and transneuronal reaction, is found in cells of the inferior olive after cerebellar ablation in the cat. Its chief features are central chromatolysis and hypertrophy of the peripherally located granular endoplasmatic reticulum with accumulation of electron-dense material in ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(85)90399-4

    authors: Boesten AJ,Voogd J

    更新日期:1985-10-24 00:00:00

  • Voltage dependency of light-evoked on-off transient amacrine cell responses in carp retina.

    abstract::The voltage dependency of the ON and the OFF components of transient amacrine cell responses was studied using two-electrode voltage-clamp and current-clamp techniques in the isolated retina of the carp. The two independent approaches gave similar data. When cells were voltage clamped near their resting potentials, bo...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(96)12900-1

    authors: Djamgoz MB,Low JC,Saito T,Toyoda JI,Yamada M

    更新日期:1996-08-23 00:00:00

  • Frequency dependent inhibition of the nicotinic transmission by serotonin in vesical pelvic ganglia of the rabbit.

    abstract::Intracellular recordings were made from neurons in rabbit vesical pelvic ganglia (VPG), in vitro. Increasing the frequency of preganglionic-nerve stimulations from 0.1-1 Hz to 10-20 Hz facilitated fast excitatory postsynaptic potentials (EPSPs), resulting in a generation of action potentials. Acetylcholine-induced res...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(89)90572-7

    authors: Nishimura T,Yoshida M,Nagatsu I,Akasu T

    更新日期:1989-08-28 00:00:00

  • Effect of TJ-960 (a Japanese herbal medicine) on free radical changes within an iron-induced focal epileptogenic region in rat brain measured by in vivo L-band electron spin resonance.

    abstract::In vivo L-band electron spin resonance (ESR) system was used to measure the decay of nitroxide radicals in the living rat cerebrum containing a cortical area with an iron-induced epileptogenic region. Carbamoyl-PROXYL (3-carbamoyl-2,2,5,5-tetramethyl-1-pyrrolinyloxy) was injected intraperitoneally. The decay of nitrox...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(96)12412-5

    authors: Komatsu M,Hiramatsu M,Yokoyama H,Willmore LJ

    更新日期:1996-03-01 00:00:00

  • Glycine transporter GlyT1, but not GlyT2, is expressed in rat dorsal root ganglion--Possible implications for neuropathic pain.

    abstract::Glycinergic inhibitory neurotransmission plays a pivotal role in the development of neuropathic pain. The glycine concentration in the synaptic cleft is controlled by the glycine transporters GlyT1 and GlyT2. GlyT1 is expressed throughout the central nervous system, while GlyT2 is exclusively located in glycinergic ne...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2015.06.026

    authors: Schlösser L,Barthel F,Brandenburger T,Neumann E,Bauer I,Eulenburg V,Werdehausen R,Hermanns H

    更新日期:2015-07-23 00:00:00

  • 5-Methoxytryptamine is metabolized by monoamine oxidase A in the pineal gland and plasma of golden hamsters.

    abstract::Pineal concentrations of 5-methoxytryptamine, 5-methoxytryptophol, 5-methoxyindole acetic acid and melatonin were determined using high performance liquid chromatography following administration of different monoamine oxidase (MAO) inhibitors (clorgyline, pargyline and deprenyl) to golden hamsters. Plasma concentratio...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(91)90923-h

    authors: Raynaud F,Pévet P

    更新日期:1991-02-25 00:00:00

  • C3a expressed in the central nervous system protects against LPS-induced shock.

    abstract::Complement is implicated in the pathogenesis of inflammatory disorders of the central nervous system (CNS), like multiple sclerosis, Alzheimer's disease, and trauma. The anaphylatoxins C3a and C5a are thought to be the major contributors to complement-mediated inflammation in the CNS, likely mediating their effects vi...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2005.07.015

    authors: Boos L,Szalai AJ,Barnum SR

    更新日期:2005-10-21 00:00:00

  • Differential effects of the aging process on the morphology of the hypothalamic ventromedial nucleus of male and female rats.

    abstract::We investigated the effects of aging on the neuroanatomical sex dimorphisms of the rat hypothalamic ventromedial nucleus (VMN). Stereological methods were used to estimate the volume of the VMN and the total number and size of its neurons, including their dendritic trees, in males and females aged 6 and 24 months. No ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(01)02294-7

    authors: Madeira MD,Ferreira-Silva L,Ruela C,Paula-Barbosa MM

    更新日期:2001-11-13 00:00:00

  • Hippocampal seizures and striatal regulation: a possible functional pathway.

    abstract::Experimental findings have suggested the possibility of a functional relationship between the basal ganglia and the hippocampus. Previous research has revealed a predominantly inhibitory action of the caudate nucleus (CN) and an excitatory effect of the globus pallidus (GP) on electrically induced hippocampal afterdis...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(86)90526-4

    authors: La Grutta V,Sabatino M,Ferraro G,Liberti G,La Grutta G

    更新日期:1986-12-23 00:00:00

  • Magnetic fields abolish nychthemeral rhythmicity of responses of Purkinje cells to the pineal hormone melatonin in the pigeon's cerebellum.

    abstract::The effects of micro-electrophoretically applied melatonin on the electrical activity of Purkinje cells in the cerebellum of anaesthetized pigeons were studied. The proportion of excitatory and inhibitory responses to the pineal indoleamine varied significantly depending on whether the cells were tested during the day...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(86)90072-8

    authors: Demaine C,Semm P

    更新日期:1986-12-12 00:00:00

  • Displaced ganglion cells in carp retina revealed by the horseradish peroxidase technique.

    abstract::Displaced ganglion cells were identified in the carp retina by the retrograde axonal transport of horseradish peroxidase injected into the optic tectum. Cells in the ganglion cell layer were all labelled, while in the amacrine cell layer only 1/4000 cells were labelled. Because of such low population, it is unlikely t...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(78)90064-2

    authors: Tachibana M

    更新日期:1978-09-01 00:00:00

  • Difference in water intake but not in renal sympathetic nerve activity in response to central salt-loading or angiotensin II in awake Dahl salt-sensitive and -resistant rats.

    abstract::Experiments were conducted to examine whether renal sympathetic nerve activity (RSNA) and water intake in response to central salt-loading or angiotensin II (A II) differ between freely-moving Dahl salt-sensitive (DS) and -resistant (DR) rats maintained on a low-salt diet. Intracerebroventricular (i.c.v.) administrati...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(98)00005-6

    authors: Kato K,Saita M,Ishizuka Y,Nose K,Kunitake T,Hanamori T,Kannan H

    更新日期:1998-02-06 00:00:00

  • A single session of exercise as a modulator of short-term learning in healthy individuals.

    abstract:BACKGROUND:A single session of aerobic exercise is linked to faster motor responses; however, the effect on rate of short-term learning is less clear. The objective was to evaluate the influence of a single bout of aerobic exercise on the rate of short-term acquisition of a shape-letter association task requiring a mot...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2016.06.064

    authors: Sage MD,Beyer KB,Laylor M,Liang C,Roy EA,McIlroy WE

    更新日期:2016-08-26 00:00:00

  • Development of mammalian nerve-muscle synapses in culture: lack of interference by antibodies to the neural cell adhesion molecule N-CAM and its L2/HNK-1 carbohydrate epitope.

    abstract::Rat myotubes were cultured with embryonic mouse spinal cord explants. After 4 days of co-culture, (miniature) endplate potentials, (M)EPPs, could be detected in 20-40% of the nerve-contacted myotubes. Polyclonal antibodies against the neural cell adhesion molecule N-CAM and monoclonal antibodies to its L2/HNK-1 carboh...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(87)90368-5

    authors: Mehrke G,Jockusch H,Schachner M

    更新日期:1987-08-05 00:00:00

  • Axonal projections to the ventrolateral nucleus of the solitary tract revealed by double labelling of retrograde fluorescent markers in the cat.

    abstract::The retrofacial nucleus project bilaterally to the ventrolateral nucleus of the tractus solitarius (vlNTS) as revealed by means of retrograde transport of the fluorescent markers, Fast blue (FB) and Diamidino yellow (DY), in the cat. Some of the neurons of the retrofacial nucleus send axonal ramifications to both vlNT...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(87)90415-0

    authors: Portillo F,Pásaro R

    更新日期:1987-05-19 00:00:00

  • Differential activity in the premotor cortex subdivisions in humans during mental calculation and verbal rehearsal tasks: a functional magnetic resonance imaging study.

    abstract::To investigate a possible role of the lateral premotor cortex in human cognitive processes, we compared brain activity during mental-operation numeral (MO-numeral) and verbal rehearsal (VR) tasks, using block-design functional MRI. Sixteen healthy subjects serially added a series of single-digit numbers during the MO-...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(03)00692-x

    authors: Hanakawa T,Honda M,Okada T,Fukuyama H,Shibasaki H

    更新日期:2003-08-28 00:00:00

  • Finger force sharing during an adapted power grip task.

    abstract::This study analyses the finger force sharing using power grip task with adapted experimental conditions. This paradigm limits as much as possible the external constraints when the Index (I), Middle (M), Ring (R) and Little (L) fingers act simultaneously: the thumb did not oppose the other fingers and no secondary mome...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2011.09.050

    authors: Vigouroux L,Rossi J,Foissac M,Grélot L,Berton E

    更新日期:2011-10-31 00:00:00

  • Diurnal rhythms of immunoreactive melatonin in the aqueous humor and serum of male pigmented rabbits.

    abstract::Using specific radioimmunoassays, melatonin was quantified in the aqueous humor and serum of male pigmented rabbits adapted to 12L:12D with lights on at 06.00 h. Melatonin concentrations in the aqueous humor at 08.00 and 16.00 h were similar (mean: 5.23 pg/ml) and significantly lower than those at 22.00 and 01.00 h (m...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(90)90092-n

    authors: Yu HS,Yee RW,Howes KA,Reiter RJ

    更新日期:1990-08-24 00:00:00

  • The effects of unilateral 6-hydroxydopamine lesions in the substantia nigra on hippocampal noradrenaline-induced feeding and other behaviour in the rat.

    abstract::The latency, duration of feeding and number of feeding periods recorded from rats after noradrenaline injection to the hippocampus show little change after unilateral 6-hydroxydopamine injections to the substantia nigra. It is suggested that 6-hydroxydopamine-induced weight losses result from non-specific effects of i...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(77)90194-x

    authors: Oades RD

    更新日期:1977-04-01 00:00:00

  • Elevated endogenous nitric oxide synthase inhibitor in schizophrenic plasma may reflect abnormalities in brain nitric oxide production.

    abstract::Cellular origins of methylarginines are not precisely known but the presence of free methyl and dimethylarginines in the brain were reported. We have investigated the circulating concentrations of asymmetrical dimethylarginine NG,NG-dimethylarginine (ADMA), NG,NG-dimethylarginine (SDMA), nitrate and nitrite levels in ...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(96)12972-4

    authors: Das I,Khan NS,Puri BK,Hirsch SR

    更新日期:1996-09-13 00:00:00

  • Spatial memory and learning deficits after experimental pneumococcal meningitis in mice.

    abstract::Survivors of bacterial meningitis frequently suffer from long-term sequelae, particularly from learning and memory deficits. For this reason, spatial memory and learning was studied in a mouse model of ceftriaxone-treated Streptococcus pneumoniae meningitis. Persistent deficits of spatial learning despite normal motor...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(00)01645-1

    authors: Wellmer A,Noeske C,Gerber J,Munzel U,Nau R

    更新日期:2000-12-22 00:00:00

  • Cognitive operations in the human caudate nucleus.

    abstract::We have addressed the role of the head of caudate nucleus in taks of lexical decision, semantic categorization, reading aloud, memory retrieval and object naming by recording neuronal activity from depth electrodes in parkinsonism patients. The firing rate of cells was increased within 400-600 ms when semantic process...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(97)00680-0

    authors: Abdullaev YG,Melnichuk KV

    更新日期:1997-10-03 00:00:00

  • Immunofluorescence analysis of the expression of Norpeg (Rai14) in retinal Müller and ganglion cells.

    abstract::Novel retinal pigment epithelial cell gene (Norpeg, Rai14), a developmentally regulated mouse gene, encodes a protein containing six ankyrin repeats and a coiled-coil domain. The objective of the present study was to characterize the Norpeg protein and to analyze its expression in mouse retina using an antibody prepar...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2006.06.006

    authors: Kutty RK,Samuel W,Chen S,Vijayasarathy C,Dun Y,Mysona B,Wiggert B,Smith SB

    更新日期:2006-09-01 00:00:00

  • Cardiovascular risk factors and Alzheimer's disease: a genetic association study in a population aged 85 or over.

    abstract::Increasing evidence suggests a relation between vascular disorders and late-onset Alzheimer's disease (AD). We performed an association analysis of low-density lipoprotein receptor-related protein (LRP), lipoprotein lipase (LPL), and angiotensin converting enzyme (ACE) genes, known to be involved in vascular disorders...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/s0304-3940(00)01467-1

    authors: Myllykangas L,Polvikoski T,Sulkava R,Verkkoniemi A,Tienari P,Niinistö L,Kontula K,Hardy J,Haltia M,Pérez-Tur J

    更新日期:2000-10-13 00:00:00

  • Labeling of motoneurons supplying the cutaneous maximus muscle in the rat, following injection of the triceps brachii muscle with horseradish peroxidase.

    abstract::Injection of the triceps brachii muscle of the rat with horseradish peroxidase (HRP) led to labeling of motoneurons in the dorsolateral and ventral aspects of the ventral grey horn of the brachial spinal cord. Ventral, labeled neurons were absent, however, in rats in which the motor branches of the radial nerve to tri...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(85)90596-8

    authors: Haase P,Hrycyshyn AW

    更新日期:1985-10-10 00:00:00

  • Muscarinic cholinergic receptors in dorsal root ganglia of chick embryo: a radioligand binding and immunocytochemical study.

    abstract::The presence and micro-anatomical localization of muscarinic cholinergic receptors were assessed in dorsal root ganglia of chick embryo during development using radioligand binding and immunocytochemical techniques, respectively. The non-selective muscarinic cholinergic receptor radioligand [3H]quinuclidinyl benzilate...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(95)11474-b

    authors: Tata AM,Biagioni S,Ricci A,Amenta F,Augusti-Tocco G

    更新日期:1995-04-21 00:00:00

  • Urotensin I-like immunoreactivity in amacrine cells of the goldfish retina.

    abstract::Urotensin I-like immunoreactivity (UILI), in different localization from that of corticotropin releasing factor-like immunoreactivity (CRFLI), in the goldfish retina has been demonstrated by means of radioimmunoassay, high-performance liquid chromatography (HPLC) and immunohistochemistry. Radioimmunoassay showed 350 +...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(87)90199-6

    authors: Sakanaka M,McMaster D,Chohan K,Shibasaki T,Stell WK,Lederis K

    更新日期:1987-04-23 00:00:00

  • Induction of heme oxygenase-1 (HO-1) after traumatic brain injury in the rat.

    abstract::The induction of heme oxygenase-1 (HO-1), the 32 kDa heat shock protein, was examined in the traumatized rat brain. At 24 h after either mild or severe brain injury or sham surgery, HO-1 was immunolocalized in fixed sections of brain. After mild brain injury, hemorrhage was apparent in the subarachnoid space, external...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/0304-3940(95)12042-3

    authors: Fukuda K,Panter SS,Sharp FR,Noble LJ

    更新日期:1995-10-20 00:00:00

  • Striatal dopamine in the response of brain and liver unsaturated and saturated free fatty acids following administration of C75 in CD-1 mice.

    abstract::In order to clarify the mechanism of action of cerulenin analog, C75, known to suppress feeding behavior, food intake was measured in adult CD-1 male mice n=5 per group, treated i.p. with 10 and 20mg/kg of C75. Animals in both treatment groups had significantly lower 24h food consumption rate relative to the control g...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2009.12.019

    authors: Binienda ZK,Ross IA,Gough B,Riccio T,Kim CS,Ali SF

    更新日期:2010-01-29 00:00:00

  • In vivo BDNF modulation of adult functional and morphological synaptic plasticity at hippocampal mossy fibers.

    abstract::Brain-derived neurotrophic factor (BDNF) has been proposed as a key regulator and mediator of long-term synaptic modifications related to learning and memory maintenance. Our previous studies show that application of high-frequency stimulation (HFS) sufficient to elicit LTP at the dentate gyrus (DG)-CA3 pathway produc...

    journal_title:Neuroscience letters

    pub_type: 杂志文章

    doi:10.1016/j.neulet.2008.08.069

    authors: Gómez-Palacio-Schjetnan A,Escobar ML

    更新日期:2008-11-07 00:00:00