Abstract:
:We performed an electron microscopic study in layers II-III of S-1 in rats, using postembedding immunogold histochemistry to compare the synaptic distribution of N-methyl D-aspartate (NMDA) receptors (assessed with an antibody for the NMDAR1 subunit) with that of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors (assessed with an antibody for the GluR2/3 subunit). Labeling for each receptor was concentrated at active zones of asymmetric synapses. Analysis of the tangential position of gold particles along the postsynaptic active zone revealed that NMDA receptors were at highest concentration in the middle of the synaptic apposition, whereas AMPA receptors were concentrated in an annulus away from its center. These data support the view that the two types of receptors are anchored by distinct subsynaptic assemblies, and raise the possibility of independent synaptic microdomains.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Kharazia VN,Weinberg RJdoi
10.1016/s0304-3940(97)00846-xsubject
Has Abstractpub_date
1997-11-28 00:00:00pages
41-4issue
1-2eissn
0304-3940issn
1872-7972pii
S0304-3940(97)00846-Xjournal_volume
238pub_type
杂志文章abstract::Olivary hypertrophy, a combined retrograde and transneuronal reaction, is found in cells of the inferior olive after cerebellar ablation in the cat. Its chief features are central chromatolysis and hypertrophy of the peripherally located granular endoplasmatic reticulum with accumulation of electron-dense material in ...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(85)90399-4
更新日期:1985-10-24 00:00:00
abstract::The voltage dependency of the ON and the OFF components of transient amacrine cell responses was studied using two-electrode voltage-clamp and current-clamp techniques in the isolated retina of the carp. The two independent approaches gave similar data. When cells were voltage clamped near their resting potentials, bo...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(96)12900-1
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(89)90572-7
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(96)12412-5
更新日期:1996-03-01 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2015.06.026
更新日期:2015-07-23 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(91)90923-h
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2005-10-21 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(01)02294-7
更新日期:2001-11-13 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(78)90064-2
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:1998-02-06 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2016.06.064
更新日期:2016-08-26 00:00:00
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2011.09.050
更新日期:2011-10-31 00:00:00
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:1995-10-20 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2008-11-07 00:00:00