Induction of heme oxygenase-1 (HO-1) after traumatic brain injury in the rat.

Abstract:

:The induction of heme oxygenase-1 (HO-1), the 32 kDa heat shock protein, was examined in the traumatized rat brain. At 24 h after either mild or severe brain injury or sham surgery, HO-1 was immunolocalized in fixed sections of brain. After mild brain injury, hemorrhage was apparent in the subarachnoid space, external capsule and cerebellum. HO-1 was induced in similar areas in macrophages in the subarachnoid space and in glia in the cortex adjacent to the site of impact, the ipsilateral hippocampus, external capsule and cerebellum. After severe brain injury, extensive hemorrhage occurred in the external capsule, hippocampus and cerebellum. HO-1 was induced in glia in these areas of hemorrhage but was more extensive than that seen after mild injury and included the contralateral external capsule and hippocampus. These findings demonstrate remarkable induction of HO-1 in glia in the injured brain. Since heme is a potent inducer of HO-1, it is likely that the subarachnoid and/or intraparenchymal blood induced HO-1 in the glia where the heme was metabolized to biliverdin, iron, and carbon monoxide.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Fukuda K,Panter SS,Sharp FR,Noble LJ

doi

10.1016/0304-3940(95)12042-3

subject

Has Abstract

pub_date

1995-10-20 00:00:00

pages

127-30

issue

2

eissn

0304-3940

issn

1872-7972

pii

0304394095120423

journal_volume

199

pub_type

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