Induction of heme oxygenase-1 (HO-1) after traumatic brain injury in the rat.


:The induction of heme oxygenase-1 (HO-1), the 32 kDa heat shock protein, was examined in the traumatized rat brain. At 24 h after either mild or severe brain injury or sham surgery, HO-1 was immunolocalized in fixed sections of brain. After mild brain injury, hemorrhage was apparent in the subarachnoid space, external capsule and cerebellum. HO-1 was induced in similar areas in macrophages in the subarachnoid space and in glia in the cortex adjacent to the site of impact, the ipsilateral hippocampus, external capsule and cerebellum. After severe brain injury, extensive hemorrhage occurred in the external capsule, hippocampus and cerebellum. HO-1 was induced in glia in these areas of hemorrhage but was more extensive than that seen after mild injury and included the contralateral external capsule and hippocampus. These findings demonstrate remarkable induction of HO-1 in glia in the injured brain. Since heme is a potent inducer of HO-1, it is likely that the subarachnoid and/or intraparenchymal blood induced HO-1 in the glia where the heme was metabolized to biliverdin, iron, and carbon monoxide.


Neurosci Lett


Neuroscience letters


Fukuda K,Panter SS,Sharp FR,Noble LJ




Has Abstract


1995-10-20 00:00:00














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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Julliams A,Vanderhoeven I,Kuhn S,Van Broeckhoven C,De Jonghe C

    更新日期:1999-07-09 00:00:00

  • Evidence that CHP100 neuroblastoma cell death induced by N-methyl-D-aspartate involves L-arginine-nitric oxide pathway activation.

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Corasaniti MT,Tartaglia RL,Melino G,Nisticò G,Finazzi-Agrò A

    更新日期:1992-12-07 00:00:00

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Pralong E,Pollo C,Bloch J,Villemure JG,Daniel RT,Tétreault MH,Debatisse D

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Suzuki R,Porreca F,Dickenson AH

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Suzuki T,Kobayashi K,Nagatsu T

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  • Treadmill exercise suppresses nigrostriatal dopaminergic neuronal loss in 6-hydroxydopamine-induced Parkinson's rats.

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Yoon MC,Shin MS,Kim TS,Kim BK,Ko IG,Sung YH,Kim SE,Lee HH,Kim YP,Kim CJ

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    journal_title:Neuroscience letters

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Bollen B,Bouslama M,Matrot B,D'Hooge R,Van den Bergh O,Gallego J

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  • c-Fos activity in the insular cortex, nucleus accumbens and basolateral amygdala following the intraperitoneal injection of saccharin and lithium chloride.

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Shimizu H,Yamanouchi K

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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  • The C-type lectin CD209b is expressed on microglia and it mediates the uptake of capsular polysaccharides of Streptococcus pneumoniae.

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    journal_title:Neuroscience letters

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    更新日期:2009-02-06 00:00:00

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Doly S,Fischer J,Salio C,Conrath M

    更新日期:2004-03-04 00:00:00

  • Effects of central administration of oxytocin-saporin cytotoxin on chronic inflammation and feeding/drinking behaviors in adjuvant arthritic rats.

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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  • α-Iso-cubebene exerts neuroprotective effects in amyloid beta stimulated microglia activation.

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    journal_title:Neuroscience letters

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Yin C,Zhou S,Jiang L,Sun X

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Mori F,Tanji K,Odagiri S,Toyoshima Y,Yoshida M,Kakita A,Takahashi H,Wakabayashi K

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    更新日期:1990-09-18 00:00:00