Abstract:
:Pineal concentrations of 5-methoxytryptamine, 5-methoxytryptophol, 5-methoxyindole acetic acid and melatonin were determined using high performance liquid chromatography following administration of different monoamine oxidase (MAO) inhibitors (clorgyline, pargyline and deprenyl) to golden hamsters. Plasma concentrations of 5-methoxytryptamine, 5-methoxytryptophol and melatonin were also measured following 5-methoxytryptamine administration to hamsters pretreated with MAO inhibitors. A significant increase in pineal and plasma 5-methoxytryptamine together with a decrease in 5-methoxytryptophol concentrations was observed after clorgyline or pargyline. In contrast, following deprenyl administration, no change in pineal and plasma 5-methoxyindoles was observed. These results indicate that monoamine oxidase A is responsible for oxidative deamination of 5-methoxytryptamine.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Raynaud F,Pévet Pdoi
10.1016/0304-3940(91)90923-hsubject
Has Abstractpub_date
1991-02-25 00:00:00pages
172-4issue
2eissn
0304-3940issn
1872-7972pii
0304-3940(91)90923-Hjournal_volume
123pub_type
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journal_title:Neuroscience letters
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doi:10.1016/j.neulet.2004.01.035
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2008.01.014
更新日期:2008-07-04 00:00:00
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(84)90211-8
更新日期:1984-01-27 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(93)90076-w
更新日期:1993-04-16 00:00:00
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(76)90091-4
更新日期:1976-09-01 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:1981-09-25 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章,评审
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journal_title:Neuroscience letters
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
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doi:10.1016/j.neulet.2017.07.054
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2006.03.001
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pub_type: 杂志文章
doi:10.1016/0304-3940(92)90562-l
更新日期:1992-05-25 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2012.03.004
更新日期:2012-04-18 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2017.05.003
更新日期:2017-06-09 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/j.neulet.2009.11.066
更新日期:2010-06-21 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(86)90526-4
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journal_title:Neuroscience letters
pub_type: 杂志文章
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更新日期:2002-04-19 00:00:00
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journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/s0304-3940(03)00697-9
更新日期:2003-09-25 00:00:00
abstract::Previous in vitro experiments have indicated that neuronal GABA aminotransferase (GABA-T) differs from extraneuronal GABA-T in sensitivity to certain enzyme inhibitors, including the antiepileptic drug valproate (VPA). In the present experiments, it was studied if GABA-T activity in whole tissue and synaptosomes prepa...
journal_title:Neuroscience letters
pub_type: 杂志文章
doi:10.1016/0304-3940(93)90407-c
更新日期:1993-10-01 00:00:00