Abstract:
:Loss of ovarian function, such as occurs with menopause in human beings and ovariectomy in rodents, results in weight gain. Using multiple-time regression analysis, a sensitive technique for quantifying blood-to-brain transport of peptides and polypeptides, we found that mice ovariectomized for at least 5 weeks had markedly reduced entry of the satiety factor leptin into brain. The rate of entry of leptin into brain remained reduced half a year later. The results suggest that the weight gain resulting from loss of ovarian function could be explained by decreased transport of leptin into the brain.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Kastin AJ,Akerstrom V,Maness LMdoi
10.1016/s0304-3940(01)02074-2keywords:
subject
Has Abstractpub_date
2001-09-07 00:00:00pages
69-71issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(01)02074-2journal_volume
310pub_type
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journal_title:Neuroscience letters
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