Chronic loss of ovarian function decreases transport of leptin into mouse brain.

Abstract:

:Loss of ovarian function, such as occurs with menopause in human beings and ovariectomy in rodents, results in weight gain. Using multiple-time regression analysis, a sensitive technique for quantifying blood-to-brain transport of peptides and polypeptides, we found that mice ovariectomized for at least 5 weeks had markedly reduced entry of the satiety factor leptin into brain. The rate of entry of leptin into brain remained reduced half a year later. The results suggest that the weight gain resulting from loss of ovarian function could be explained by decreased transport of leptin into the brain.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Kastin AJ,Akerstrom V,Maness LM

doi

10.1016/s0304-3940(01)02074-2

keywords:

subject

Has Abstract

pub_date

2001-09-07 00:00:00

pages

69-71

issue

1

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(01)02074-2

journal_volume

310

pub_type

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