Persistence of visual responsiveness in the lateral geniculate nucleus of rats treated with monosodium-L-glutamate.

Abstract:

:Normal treatment of rats with monosodium-L-glutamate (MSG) resulted in extensive degeneration of the inner nuclear layer of the retina. The retino-hypothalamic projection was still functional as these rats entrained their circadian food intake rhythm to the light-dark cycle. A normal proportion of dorsal lateral geniculate nucleus (LGNd) cells in MSG rats responded to visual stimulation. The response pattern, latency and variability of LGNd cells at different times (3-18 months) after treatment were comparable to those of normal rats. These results demonstrate the MSG-induced retinal damage does not lead to blindness in the rat. The similarity in pathophysiology between MSG lesioned rats and animals exposed to constant illumination is discussed.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Groos G

doi

10.1016/0304-3940(81)90407-9

subject

Has Abstract

pub_date

1981-09-25 00:00:00

pages

293-7

issue

3

eissn

0304-3940

issn

1872-7972

pii

0304-3940(81)90407-9

journal_volume

25

pub_type

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