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Gastrin releasing peptide-induced satiety is associated with hypothalamic and brainstem changes in chicks.

Abstract：

:Gastrin releasing peptide (GRP) is involved in the stimulation of gastric acid release from the stomach. It also mediates effects on feeding behavior. It is associated with anorexigenic effects in both mammalian and avian species, but the mechanism of action is unknown in any species. The aim of the present study was thus to investigate the hypothalamic and brainstem mechanisms mediating GRP-induced satiety in chicks. In Experiment 1, chicks that received intracerebroventricular (ICV) injection of GRP reduced food intake for up to 150 min following injection and reduced water intake up to 120 min following injection. In Experiment 2, chicks that were food restricted following GRP injection did not reduce water intake. Alimentary canal transit time was not affected by GRP in Experiment 3. A behavior analysis was conducted in Experiment 4, revealing that GRP-treated chicks reduced feeding pecks. In Experiment 5, GRP-treated chicks had increased c-Fos immunoreactivity in the lateral hypothalamus, paraventricular nucleus, and arcuate nucleus of the hypothalamus, and the nucleus of the solitary tract. Collectively, these results demonstrate that central GRP causes anorexigenic effects that are associated with hypothalamic changes without affecting other behaviors.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Bohler M,Dougherty C,Tachibana T,Gilbert ER,Cline MA

doi

10.1016/j.neulet.2019.134529

subject

Has Abstract

pub_date

2019-11-20 00:00:00

pages

134529

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(19)30632-9

journal_volume

713

pub_type

杂志文章

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