Abstract：
:Two electrophysiologically distinct cell types were found with intracellular recordings for the first time in an in vitro preparation of the olfactory epithelium of the salamander, Ambystoma tigrinum. Intracellular recordings showed that Type I cells did not discharge action potentials but had high resting membrane potentials (-50 to -104 mV) and relatively low input resistances. Type II cells had resting membrane potentials of -24 to -52 mV, high input resistances, and discharged upon penetration and to depolarizing current steps. The discharge pattern of Type II cells showed the following characteristics: (1) decreased spike latency and increased discharge frequency with increasing current step intensity; (2) relatively slowly adapting spike trains; and (3) varying spike amplitude during repetitive discharges. The superficial location in the epithelium of the Type I cells implies that they may be sustentacular cells with glial-like electrophysiological properties. The Type II cells are presumably olfactory receptor cells, based on the characteristics of their spike discharge to depolarizing current and their intermediate location within the olfactory epithelium.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Masukawa LM,Kauer JS,Shepherd GMdoi
10.1016/0304-3940(83)90527-xsubject
Has Abstractpub_date
1983-01-31 00:00:00pages
59-64issue
1eissn
0304-3940issn
1872-7972pii
0304-3940(83)90527-Xjournal_volume
35pub_type
杂志文章abstract：:A combination of immunocytochemistry with transmitter specific autoradiography at the electron microscopic level was used to identify vasoactive intestinal polypeptide (VIP)- or ACTH-containing neurons and serotoninergic nerve terminals in the suprachiasmatic (SCN) and arcuate nuclei (AN). We observed nerve terminals ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(84)90068-5
更新日期：1984-02-10 00:00:00
abstract：:The distribution of cells concentrating R 5020, a potent synthetic progestin, in the brain and pituitary of estrogen-primed ovariectomized rat was investigated by radioautography. In the brain, radioactivity was found concentrated in nuclei of neurons in the preoptic region (nucleus (n.) preopticus pars suprachiasmati...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(78)90203-3
更新日期：1978-10-01 00:00:00
abstract：:Early intervention following combat deployment has the potential to prevent posttraumatic stress disorder (PTSD), but there is a need for greater understanding of the factors that contribute to PTSD symptom progression. This study investigated: (1) fear-potentiated startle during a fear extinction, (2) white matter mi...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2016.02.041
更新日期：2016-04-08 00:00:00
abstract：:Sleep fragmentation due to intermittent nocturnal arousal resulting in a reduction of total sleep time and sleep efficiency is a common symptom among people with Alzheimer's disease (AD) and elderly people with normal cognitive function. Although epidemiological studies have indicated an association between sleep frag...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2017.05.054
更新日期：2017-07-13 00:00:00
abstract：:Constant bright light (LL) suppresses 24-h melatonin and many other behavioral and physiological rhythms in pigeons. LL also strongly suppresses sleep. Daily melatonin infusions in LL restore sleep to normal nocturnal levels of a light-dark cycle and continuous infusions sustain it for at least 10 days. Restoration of...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(92)90026-4
更新日期：1992-10-12 00:00:00
abstract：:This study examined c-Fos expression in selected brain areas consequent to intraperitoneal (IP) administration of saccharin and lithium chloride. Rats were tested for aversion to the saccharin as measured by flavor consumption and orofacial reactions in the taste reactivity (TR) test. It was found that intraperitoneal...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2017.03.025
更新日期：2017-04-24 00:00:00
abstract：:To identify the BOLD effects related to olfaction in humans, we recorded functional magnetic resonance imaging (fMRI) scans in response intravenously instilled thiamine propyl disulfide (TPD) and thiamine tetrahydrofurfuryl disulfide monohydrochloride (TTFD). TPD and TTFD evoked a strong and weak odor sensation, respe...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2007.06.039
更新日期：2007-08-09 00:00:00
abstract：:Neural cell adhesion molecules (NCAMs) are members of the immunoglobulin superfamily and are involved in synaptic rearrangements in the mature brain. There are three major NCAM forms: NCAM 180, NCAM 140 and NCAM 120. Several studies report that NCAMs play a central role in memory. In the present study we investigated ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(02)00328-2
更新日期：2002-06-28 00:00:00
abstract：:Incorporation of ubiquitin and ubiquitin-related proteins including p62 into neuronal intranuclear inclusions (NIIs) has been reported in a variety of neurodegenerative diseases. However, involvement of autophagy-specific proteins (NBR1 and LC3) in NIIs has not been mentioned. We immunohistochemically examined the bra...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2012.06.026
更新日期：2012-08-01 00:00:00
abstract：:Protein profiling of cerebrospinal fluid in Guillain-Barrè syndrome (GBS), an acute and immune-mediated disease affecting the peripheral nervous system, was performed by two-dimensional electrophoresis. Significant modulated spots in GBS patients vs. control groups (a group of multiple sclerosis patients and one of he...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2010.08.060
更新日期：2010-11-12 00:00:00
abstract：:We investigated the role of local cutaneous signals and of co-contraction of antagonists in repeated judgements of heaviness of weights lifted by flexor pollicis longus. A reference weight lifted by right thumb flexion was matched to a weight lifted by left thumb flexion. Anaesthesia of the right thumb, or of the supe...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(95)12179-x
更新日期：1995-12-15 00:00:00
abstract：:Noxious peripheral stimulation induces the expression of various proto-oncogenes in rat spinal neurons. However, proto-oncogene expression seems to differ depending on the mode of the stimulus. Here, we report that noxious cutaneous ultraviolet (UV) irradiation results in a nearly 8-fold increase in junD mRNA levels i...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(92)90654-p
更新日期：1992-02-17 00:00:00
abstract：:Proton-induced Na+ currents (INa(H] were measured in precursor cells from chick dorsal root ganglia with whole-cell patch-clamp recording. Precursor cells were isolated using the method of Rohrer et al. (EMBO. J., 4 (1985) 1709-1714) and fast pH changes were applied with a technique developed by Davies et al. (J. Phys...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(89)90270-x
更新日期：1989-04-24 00:00:00
abstract：:Unilateral transtympanic administration of the sodium channel blocker tetrodotoxin (75 microl of 3 mM TTX in 0.1 M citrate buffer, pH 5.0) produced behavioral symptoms indicative of unilateral vestibular disruption. Following survival times of 2 and 24 h immunocytochemistry for Fos revealed asymmetric labeling in the ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(02)01426-x
更新日期：2003-03-13 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(96)12823-8
更新日期：1996-07-26 00:00:00
abstract：:The effect of electroshock on the brain levels of somatostatin mRNA were evaluated by in situ hybridization using a selective oligonucleotide probe. Rats were submitted to single or repeated (7 days, one session for each day) sessions of electroshock. There was a marked increase of the expression of somatostatin mRNA ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(93)90321-b
更新日期：1993-04-30 00:00:00
abstract：:Hemispheric asymmetries in spatial processing are generally considered to be responsible for the shorter reaction time (RT) of the left hand classically observed for right-handers when pointing at targets. Surprisingly, despite the special role which the right cerebral hemisphere is known to play in visual attention, ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(01)02313-8
更新日期：2001-11-23 00:00:00
abstract：:Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine involved in the development and maintenance of inflammatory and neuropathic pain conditions. The mechanisms by which TNF-alpha elicits pain behavior are still incompletely understood. Numerous studies suggest that TNF-alpha sensitizes primary affere...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2008.01.070
更新日期：2008-04-04 00:00:00
abstract：:Neuronal voltage-dependent P/Q Ca2+ channels are genetically abnormal in many cases of familial hemiplegic migraine and possibly associated with the more common forms of migraine with and without aura. Besides the brain, these channels are found in motor nerve endings where they control stimulation-induced acetylcholi...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(99)00820-4
更新日期：1999-12-10 00:00:00
abstract：:The present study investigated the changes in the expression of regulators of G-protein-coupled signaling proteins RGS2, 7 and 8 in gerbil hippocampus to better understand alterations of G-protein-coupled receptors signaling after cerebral ischemia. In situ hybridization revealed a transient, robust early increase in ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2006.04.037
更新日期：2006-07-31 00:00:00
abstract：:A trait locus for electroencephalographic photoparoxysmal response (PPR) has been mapped to the chromosomal region 6p21 near a susceptibility locus for juvenile myoclonic epilepsy (JME). Linkage disequilibrium mapping revealed strong associations between JME and polymorphisms of the gene encoding the bromodomain-conta...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2006.02.026
更新日期：2006-05-29 00:00:00
abstract：:To better understand the pathophysiological role of Src protein, a non-receptor protein tyrosine kinase of 60kDa, in the ischemic brain, we investigated the time course and regional distribution of active Src expression by using a specific antibody against Tyr416 phosphorylated Src (phospho-Src) in the rat hippocampus...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2005.01.015
更新日期：2005-05-20 00:00:00
abstract：:Electrical high frequency deep brain stimulation (DBS) of the globus pallidus internus (GPi) or the subthalamic nucleus (STN) has dramatic beneficial motor effects in advanced Parkinson's disease (PD). However, the mechanisms underlying these clinical results remain unclear. It is proposed that the gamma-aminobutyric ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2004.08.050
更新日期：2004-11-23 00:00:00
abstract：:Narcolepsy is characterized, beside other features, by excessive daytime sleepiness and disturbed sleep at night. The pineal hormone melatonin may affect the sleep characteristics. The aim of the study was to compare the circadian rhythm in salivary melatonin in narcoleptic patients with that in control healthy subjec...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2008.03.076
更新日期：2008-05-30 00:00:00
abstract：:The intra-adrenal distribution of nitric oxide synthase (NOS)-immunoreactive nerve fibres was studied in rats subjected to various denervations. Splanchnic nerve section eliminated the NOS-immunoreactive nerve fibres which innervate adrenal chromaffin and neuronal cells. It did not affect those innervating blood vesse...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(95)11514-w
更新日期：1995-05-05 00:00:00
abstract：:We have previously demonstrated that repeated exposure of adult rat hippocampal slices to brief episodes of hypoxia induce a sustained decrease in the threshold of stimulus-evoked population spike discharges in CA1 pyramidal neurons [O. Godukhin, A. Savin, S. Kalemenev, S. Levin, Neuronal hyperexcitability induced by ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2004.11.057
更新日期：2005-03-22 00:00:00
abstract：:In the present study, newborn male Wistar rats were injected, subcutaneously, five times, every other day, with monosodium glutamate (MSG, 4 g/kg bw) or saline (as control, C), during the neonatal period. MSG animals developed destruction of the arcuate nuclei (ARC) with absence of NPY-immunoreactive cell bodies, whic...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2005.12.043
更新日期：2006-05-01 00:00:00
abstract：:The aim of this study was to clarify whether 12-lipoxygenase (12-LOX) activation was involved in reactive oxygen species (ROS) generation, extensive poly(ADP-ribose) polymerase (PARP) activation and neuronal death induced by glucose-deprivation, followed by glucose-reload (GD/R). The decrease of neuronal viability and...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2007.09.073
更新日期：2007-12-18 00:00:00
abstract：:Age-related impairment of learning and memory is a common phenomenon in humans and animals, yet the underlying mechanism remains unclear. We hypothesize that a small ubiquitin-related modifier (Sumo) might correlate with age-related loss of learning and memory. To test this hypothesis, the present study evaluated age-...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2012.04.051
更新日期：2012-06-19 00:00:00
abstract：:Application of a GABAA (gamma-aminobutyric acid-A) receptor antagonist through a microdialysis probe into the forelimb primary motor cortex of ketamine-anesthetized rats induced electromyographic activity in the contralateral forelimb. This activity consisted of spontaneous forelimb movements with a frequency of 0.8 +...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(93)90531-o
更新日期：1993-02-19 00:00:00
