Memantine increases brain production of kynurenic acid via protein kinase A-dependent mechanism.

abstract：:The pharmacological properties of presynaptic calcium (Ca) channels on rat hippocampal mossy fiber synaptosomes were characterized by determining the inhibitory potencies for various classes of Ca antagonists on depolarization-induced Ca mobilization and the release of dynorphin A(1-8)-like immunoreactivity (Dyn-LI). ...

journal_title：Neuroscience letters

authors： Terrian DM,Damron DS,Dorman RV,Gannon RL

更新日期：1989-12-04 00:00:00

abstract：:Acetylcholinesterase (AChE) colocalizes with amyloid-beta peptide (A beta) deposits present in the brain of Alzheimer's patients. Recent studies showed that A beta 1-40 can adopt two different conformational states in solution (an amyloidogenic conformer, A beta ac, and a non-amyloidogenic conformer, A beta nac) which...

journal_title：Neuroscience letters

authors： Alvarez A,Bronfman F,Pérez CA,Vicente M,Garrido J,Inestrosa NC

更新日期：1995-12-01 00:00:00

abstract：:Molecular mechanisms regulating positions of oligodendrocyte precursor cells (OPCs) remain unclear in developing cerebral cortex. To explore the mechanisms, we investigated how Plexin-A4, receptor of Semaphorin in OPCs, is involved in the positioning. We found that Plexin-A4 knockout mice exhibited (1) an increased nu...

journal_title：Neuroscience letters

authors： Okada A,Tomooka Y

更新日期：2012-05-16 00:00:00

abstract：:We examined effects of centrally administered capsaicin on sympathetic nerve activity (SNA), blood pressure (BP) and heart rate (HR) in chloralose anesthetized cats (n = 18). Upon perfusion of the lower brain stem via the left vertebral artery, capsaicin (0.1-1.0 microM) caused dose-dependent increases in preganglioni...

journal_title：Neuroscience letters

authors： Seller H,Czachurski J,Zanzinger J

更新日期：1997-05-02 00:00:00

abstract：:In order to analyze the elementary mechanisms underlying caffeine-induced epileptiform discharges, hippocampal slices of guinea pigs were exposed to this drug. When the bath concentration of caffeine exceeded 0.2 mM, periodically occurring paroxysmal depolarizations (PD) in CA3 neurons appeared. They were accompanied ...

journal_title：Neuroscience letters

authors： Moraidis I,Bingmann D,Lehmenkühler A,Speckmann EJ

更新日期：1991-08-05 00:00:00

abstract：:The sensory neurons in the trigeminal ganglion which project to the muscles of mastication of the cat were studied using the retrograde transport of horseradish peroxidase. Horseradish peroxidase either was injected directly into the masticatory muscles or applied to the nerves supplying them. Numerous retrogradely la...

journal_title：Neuroscience letters

authors： Martin JW,Panneton WM

更新日期：1986-10-20 00:00:00

abstract：:Tenascin-R (TN-R) is a neural specific protein and an important molecule involved in inhibition of axonal regeneration after spinal cord injury (SCI). Here we report on rabbit-derived TN-R polyclonal antibody, which acts as a TN-R antagonist with high titer and high specificity, promoted neurite outgrowth and sproutin...

journal_title：Neuroscience letters

authors： You J,Hong SQ,Zhang MY,Zhao HL,Liu TZ,Zhou HL,Cai YQ,Xu ZM,Guo Y,Jiang XD,Xu RX

更新日期：2012-09-13 00:00:00

abstract：:We have studied a monkey model of lingual dyskinesia, due to a midbrain lesion, which is markedly increased by apomorphine. In such animals a single large intramuscular dose of haloperidol (HAL), 1 mg/kg, almost completely abolishes the apomorphine potentiation after 24 h, but 15 days later there is a 5-fold increase ...

journal_title：Neuroscience letters

authors： Bédard PJ,Boucher R

更新日期：1986-02-28 00:00:00

abstract：:The homozygous Brattleboro rat (di/di) synthesizes a vasopressin (VP) precursor with an aberrant C-terminus, which causes a hypothalamic form of diabetes insipidus. The neuroendocrine polypeptide 7B2 is present in VP and oxytocin (OT) neurons of the supraoptic and paraventricular nucleus of the hypothalamus in wild ty...

journal_title：Neuroscience letters

authors： Gabreëls BA,Verwer RW,Sonnemans MA,Sluiter AA,Ang CW,van Leeuwen FW

更新日期：1997-12-12 00:00:00

abstract：:The cloned vanilloid receptor-1 (VR1) is recognized as a common molecular target for protons, noxious heat, and vanilloids. The presence of VR1 in the dorsal root, trigeminal, and nodose ganglia has been firmly established, but it is unclear in the gut, despite this VR1 may be important for gastric mucosal homeostasis...

journal_title：Neuroscience letters

authors： Nozawa Y,Nishihara K,Yamamoto A,Nakano M,Ajioka H,Matsuura N

更新日期：2001-08-17 00:00:00

abstract：:The representation of time, space and numbers are strictly linked in the primate's cognitive system. Here we show that merely looking at number symbols biases a temporal judgment on their duration depending upon the number's magnitude. In a first experiment, a group of healthy subjects was submitted to a time estimati...

journal_title：Neuroscience letters

authors： Oliveri M,Vicario CM,Salerno S,Koch G,Turriziani P,Mangano R,Chillemi G,Caltagirone C

更新日期：2008-06-27 00:00:00

abstract：:Cochlear hair cell loss results in the secondary loss of spiral ganglion cells (SGCs). The death of these SGCs is due to apoptosis. The E2F1-cyclin dependent kinase 1 (CDK1) pathway is believed to represent an important mechanism of neuronal cell death. However, the role of this pathway in spiral ganglion neuronal apo...

journal_title：Neuroscience letters

authors： Liu YY,Wang GP,Peng Z,Guo JY,Wu Q,Xie J,Gong SS

更新日期：2016-03-23 00:00:00

abstract：:Effective treatments to improve survivability following exposure to the nerve agent soman have been established and are currently available. Unfortunately, electrographic brain seizures, neuroinflammation and brain cell death are still a potential problem even with treatment. In the present study we have characterized...

journal_title：Neuroscience letters

authors： Williams AJ,Berti R,Yao C,Price RA,Velarde LC,Koplovitz I,Schultz SM,Tortella FC,Dave JR

更新日期：2003-10-09 00:00:00

abstract：:Pain threshold and pain tolerance of heat noxious stimuli were assessed to determine whether they are equivalent when measured at three equidistant sites of both volar forearms. Heat pain threshold and tolerance were measured in 18 healthy volunteers using a standard stimulation device consisting of a thermode. Pain t...

journal_title：Neuroscience letters

authors： Schaffner N,Wittwer A,Kut E,Folkers G,Benninger DH,Candia V

更新日期：2008-08-08 00:00:00

abstract：:Local warming or cooling of the preoptic and anterior hypothalamus (PO/AH) areas evokes various thermoregulatory responses in mammals. We have hypothesized that warm- and cold-sensitive neurons recorded in the PO/AH are multiple thermostats that regulate the core temperature against heat and cold, respectively. Howeve...

journal_title：Neuroscience letters

authors： Abe J,Okazawa M,Adachi R,Matsumura K,Kobayashi S

更新日期：2003-05-15 00:00:00

abstract：:Neuronal voltage-dependent P/Q Ca2+ channels are genetically abnormal in many cases of familial hemiplegic migraine and possibly associated with the more common forms of migraine with and without aura. Besides the brain, these channels are found in motor nerve endings where they control stimulation-induced acetylcholi...

journal_title：Neuroscience letters

authors： Ambrosini A,de Noordhout AM,Alagona G,Dalpozzo F,Schoenen J

更新日期：1999-12-10 00:00:00

abstract：:Tissue-type plasminogen activator (tPA) plays important roles in the regulation of synaptic plasticity in the hippocampus and cerebellum. We found that the expression of tPA mRNA in the visual cortex was increased significantly by the peripheral administration of L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS; 100 mg...

journal_title：Neuroscience letters

authors： Mataga N,Imamura K,Shiomitsu T,Yoshimura Y,Fukamauchi K,Watanabe Y

更新日期：1996-11-08 00:00:00

abstract：:Lead is a neurotoxicant of immense public health importance. Epidemiology studies suggest that heavy metal exposure may be associated with an increased risk of cognitive decline, yet few studies to date have assessed the effect of adult lead exposure on cognitive behavior in animal models. Here, we exposed 6-week-old ...

journal_title：Neuroscience letters

authors： Engstrom AK,Xia Z

更新日期：2017-11-20 00:00:00

abstract：:The action of gamma-aminobutyric acid A (GABAA) and B (GABAB)-agonists has been studied on the membrane potential of astrocytes in explant cultures of rat spinal cord by means of intracellular microelectrode recordings. The GABAB-agonists (-)-baclofen and CGP 27 492 (3-aminopropyl phosphonous acid; 10(-6) to 10(-4) M)...

journal_title：Neuroscience letters

authors： Hösli L,Hösli E,Redle S,Rojas J,Schramek H

更新日期：1990-09-18 00:00:00

abstract：:Regeneration of reduced nicotinamide adenine dinucleotide phosphate (NADPH) is essential for the activity of glutathione redox cycling during cellular peroxide detoxification. In order to test for a function of astroglial glycogen to serve as endogenous precursor for glucose-6-phosphate, the substrate for the regenera...

journal_title：Neuroscience letters

authors： Rahman B,Kussmaul L,Hamprecht B,Dringen R

更新日期：2000-09-01 00:00:00

abstract：:1-methyl-4-phenylpyridinium ion (MPP(+)) has been shown to selectively inhibit mitochondrial function and induce a parkinsonism-like syndrome. MPP(+) stimulates the production of reactive oxygen species (ROS) and induces cell death in vitro. In this study, we investigated the protective effects of okadaic acid on MPP(...

journal_title：Neuroscience letters

authors： Ahn KH,Kim YS,Kim SY,Huh Y,Park C,Jeong JW

更新日期：2009-01-09 00:00:00

abstract：:Changes in extracellular Ca2+ concentration ([Ca2+]e) evoked by transmitters and transmitter agonists, respectively, and by elevation of bath K+ concentration were recorded in isolated segmental ganglia of the leech Hirudo medicinalis using Ca(2+)-selective microelectrodes. A 1-min bath application of kainate (10 micr...

journal_title：Neuroscience letters

authors： Lohr C,Rose CR,Deitmer JW

更新日期：1996-02-16 00:00:00

abstract：:Secondary optic projections were studied in the toad, Bufo marinus using the method of transneuronal transport of triated proline and fucose. Following a survival of 14 days after eye injection autoradiographic label was transported transneuronally to the contralateral nucleus isthmi, the deeper layers of the contrala...

journal_title：Neuroscience letters

authors： Mayner L

更新日期：1980-03-01 00:00:00

abstract：:Recombinant gamma-aminobutyric acid (GABA(A)) receptor channels containing alpha1beta2gamma2-subunits were transiently expressed in HEK293 cells. Modulation by diazepam (DZ) was investigated using the patch-clamp technique with a device for ultra-fast solution exchange. GABA activated Cl(-)-currents were potentiated w...

journal_title：Neuroscience letters

authors： Krampfl K,Lepier A,Jahn K,Franke C,Bufler J

更新日期：1998-11-13 00:00:00

abstract：:To determine how target-derived nerve growth factor (NGF) affects sensory neuronal survival and the development of topographic nerve projections in the spinal cord, anatomical studies were performed on transgenic mice that overexpress NGF in skin and other keratinized epithelial structures. Transgenic animals showed a...

journal_title：Neuroscience letters

authors： Mendelson B,Albers KM,Goodness TP,Davis BM

更新日期：1996-06-14 00:00:00

abstract：:We have compared changes in mRNA of three genes, zif268, raf B, and syntaxin 1 B, following the unilateral induction of long-term potentiation (LTP) in rats previously trained in a water maze, and in behaviourally naive animals. mRNA of all three genes was enhanced in the potentiated dentate gyrus of naive animals 3 h...

journal_title：Neuroscience letters

authors： Richter-Levin G,Thomas KL,Hunt SP,Bliss TV

更新日期：1998-07-17 00:00:00

abstract：:Noise-induced hearing loss (NIHL) severely impacts the quality of life of affected individuals. Oxidative stress resulting from noise exposure is a significant cause of NIHL. Although histone deacetylase (HDAC) inhibitors were shown to protect against NIHL, the underlying mechanism remains unclear, and it is not known...

journal_title：Neuroscience letters

authors： Yang DH,Xie J,Liu K,Peng Z,Guo JY,Yu SK,Wang GP,Gong SS

更新日期：2017-11-01 00:00:00

abstract：:In this study we investigated the effects of different semantic primes on the processing of painful stimuli. For prime stimuli, descriptors of three categories were used: somatosensory pain-related, affective pain-related, and neutral adjectives. While subjects (n=10) processed these primes, a painful laser-heat stimu...

journal_title：Neuroscience letters

authors： Dillmann J,Miltner WH,Weiss T

更新日期：2000-04-21 00:00:00

abstract：:Intolerance of uncertainty (IU), or the increased affective response to situations with uncertain outcomes, is an important component process of anxiety disorders. Increased IU is observed in panic disorder (PD), obsessive compulsive disorder (OCD) and generalized anxiety disorder (GAD), and is thought to relate to dy...

journal_title：Neuroscience letters

authors： Simmons A,Matthews SC,Paulus MP,Stein MB

更新日期：2008-01-10 00:00:00

abstract：:The microscopic distribution of omega 3 (peripheral type benzodiazepine) binding sites in sections from normal and ischaemic rat brain has been determined by emulsion autoradiography with the photoaffinity ligand [3H]PK 14105. In the normal rat brain, high densities of omega 3 sites were present in the ependymal cells...

journal_title：Neuroscience letters

authors： Benavides J,Dubois A,Gotti B,Bourdiol F,Scatton B

更新日期：1990-06-22 00:00:00