Abstract:
:The homozygous Brattleboro rat (di/di) synthesizes a vasopressin (VP) precursor with an aberrant C-terminus, which causes a hypothalamic form of diabetes insipidus. The neuroendocrine polypeptide 7B2 is present in VP and oxytocin (OT) neurons of the supraoptic and paraventricular nucleus of the hypothalamus in wild type rats. However, in the di/di rat 7B2 immunoreactivity is absent in the VP cell population, whereas 7B2 levels within the OT cells are unaffected. Remarkably, there is no obvious difference in 7B2 transcript levels between VP and OT neurons in the di/di rat hypothalamus. This study shows that the presence of mRNA does not automatically result in the subsequent synthesis of its protein. Cellular mechanisms underlying this discrepancy are discussed.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Gabreëls BA,Verwer RW,Sonnemans MA,Sluiter AA,Ang CW,van Leeuwen FWdoi
10.1016/s0304-3940(97)00883-5subject
Has Abstractpub_date
1997-12-12 00:00:00pages
5-8issue
1eissn
0304-3940issn
1872-7972pii
S0304-3940(97)00883-5journal_volume
239pub_type
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