当前位置： SCI文献检索 > NEUROSCIENCE LETTERS期刊下所有文献 > Association between the macrophage inflammatory protein-l alpha gene polymorphism and Alzheimer's disease in the Chinese population.

Association between the macrophage inflammatory protein-l alpha gene polymorphism and Alzheimer's disease in the Chinese population.

Abstract：

:Genetic polymorphisms in chemokine receptor and their natural ligand genes have been shown to modify the disease progression of Alzheimer's disease (AD). Human macrophage inflammatory protein-1 alpha (MIP-1alpha) is a chemotactic cytokine which plays a considerable role in AD pathogenesis, but its genetic contribution to AD has never been investigated. Recently, a biallelic dinucleotide microsatellite repeat (TA repeat) polymorphism has been found in the MIP-1alpha gene promoter region at position -906. We investigated whether this promoter polymorphism of MIP-1alpha gene might be responsible for susceptibility to AD in a Chinese population, utilizing a clinically well-defined group of 138 sporadic AD patients and 180 age-matched controls. We also examined the combined gene effects between the MIP-1alpha and apolipoprotein E (APOE) genes. The overall distribution of MIP-1alpha-906 alleles and genotypes was significantly different between AD cases and controls (P<0.05). The odds ratio for AD associated with the (TA)(6)/(TA)(6) versus non-(TA)(6)/(TA)(6) genotype was 1.893 (95% CI=1.208-2.967), while that for APOE varepsilon4 and MIP-1alpha (TA)(6)/(TA)(6) carriers was 7.140 (95% CI=3.222-15.823). In addition, we found that serum MIP-1alpha levels in patients with (TA)(6)/(TA)(6) genotype were increased significantly when compared with non-(TA)(6)/(TA)(6) genotype. The results indicate that the MIP-1alpha-906 (TA)(6)/(TA)(6) genotype, either by itself or interacting with the APOE varepsilon4 gene seems to be a genetic risk factor for AD. This genotype is associated with elevated serum MIP-1alpha levels in patients, which can contribute to increase the inflammatory process occurring in AD.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Li K,Dai D,Yao L,Gu X,Luan K,Tian W,Zhao Y,Wang B

doi

10.1016/j.neulet.2008.01.002

subject

Has Abstract

pub_date

2008-03-12 00:00:00

pages

125-8

issue

2

eissn

0304-3940

issn

1872-7972

pii

S0304-3940(08)00028-1

journal_volume

433

pub_type

杂志文章

相关文献

NEUROSCIENCE LETTERS文献大全
  • Amburoside A, a glucoside from Amburanacearensis, protects mesencephalic cells against 6-hydroxydopamine-induced neurotoxicity.

    abstract：:This study evaluates the potential neuroprotective properties of amburoside A, a glucoside isolated from Amburana cearensis, on rat mesencephalic cell cultures exposure to the neurotoxin 6-hydroxydopamine (6-OHDA). The parameters determined were cell viability by the 3[4,5-dimethylthiazole-2-il]-2,5-diphenyltetrazoliu...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2005.06.034

    authors： Leal LK,Nobre Júnior HV,Cunha GM,Moraes MO,Pessoa C,Oliveira RA,Silveira ER,Canuto KM,Viana GS

    更新日期：2005-11-11 00:00:00

  • GABAρ3 expression in lobule X of the cerebellum is reduced in the valproate model of autism.

    abstract：:Autism spectrum disorder (ASD) is a group of developmental disorders characterized by social interaction deficits, communication impairments, and stereotyped and repetitive behaviors. Additionally, impairments in the GABAergic circuitry have been associated with ASD. Several studies have shown that dysfunction of the ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2018.09.042

    authors： Varman DR,Soria-Ortíz MB,Martínez-Torres A,Reyes-Haro D

    更新日期：2018-11-20 00:00:00

  • Experimental demonstration of intrinsic synapses in cat's caudate nucleus.

    abstract：:The electron microscopic findings in cats after complete interruption of all afferents to caudate nucleus as well as of its efferent fibers, suggest that the type IX synapses, the presynaptic component of which contains large empty round vesicles, are formed by the axon terminals of intrinsic neurons. They make synapt...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(77)90033-7

    authors： Hassler R,Chung JW,Wagner A,Rinne U

    更新日期：1977-07-01 00:00:00

  • Molecular forms of butyrylcholinesterase in rat brain microvessels.

    abstract：:Molecular forms of butyrylcholinesterase (BuChE) were studied in microvessels isolated from rat brain, using sedimentation analysis in sucrose gradients. Three forms, G1, G2 and G4, were found with sedimentation coefficients close to 3S, 6S and 9S, respectively. The relative proportion of the 3 forms was 19% for the m...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(90)90164-5

    authors： Catalán RE,Martínez AM,Aragonés MD,Hernández F

    更新日期：1990-11-27 00:00:00

  • Chloride transport blockers inhibit the chloride-dependent glutamate binding to rat brain membranes.

    abstract：:The effects of a series of chloride transport blockers (ethacrynate, furosemide, torasemide, 4,4'-diisothiocyano-2,2'-disulfonic acid stilbene and diphenylcarboxylate) on Cl(-)-dependent L-[3H]glutamate (Glu) binding were tested in rat brain membranes, Cl-transport blockers inhibit the Ca2+/Cl(-)-induced increase in L...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(87)90151-0

    authors： Recasens M,Pin JP,Bockaert J

    更新日期：1987-02-24 00:00:00

  • Using virtual reality to analyze links between handball thrower kinematics and goalkeeper's reactions.

    abstract：:This work investigates the design of a new method to evaluate the importance of visual elements taken into account by a handball goalkeeper facing a thrower. Virtual reality was used to design and reproduce standardised situations in a controlled environment. Under such conditions, it was possible to isolate for inves...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2004.09.023

    authors： Bideau B,Multon F,Kulpa R,Fradet L,Arnaldi B,Delamarche P

    更新日期：2004-11-30 00:00:00

  • Relation between electromyogram and torque of isometric reflex contractions in man.

    abstract：:Human subjects maintained isometric plantar or dorsal flexions of the ankle in a matching task. H-reflexes of different sizes were superimposed on the steady activity. The peak-to-peak amplitude of the reflexes was measured on the electromyogram (EMG) of the soleus muscle. The size of the corresponding muscle contract...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(89)90571-5

    authors： Ruegg DG,Fluri M

    更新日期：1989-08-28 00:00:00

  • Sensitivity of pressor responses to central hypertonic saline is greatly enhanced even in pre-hypertensive spontaneously hypertensive rats.

    abstract：:It has been suggested that intracerebroventricular injection of hypertonic saline mimics the effects of a high salt diet in spontaneously hypertensive rats (SHR), a genetic model of hypertension. Intracerebroventricular injection of hypertonic saline produces an increase in blood pressure and the pressor response to h...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2006.02.002

    authors： Sasaki Y,Fujimura M,Furukawa M,Kubo T

    更新日期：2006-05-22 00:00:00

  • Reduction of EphA4 receptor expression after spinal cord injury does not induce axonal regeneration or return of tcMMEP response.

    abstract：:Spinal cord injury (SCI) causes an increase of inhibitory factors that may restrict axonal outgrowth after trauma. During the past decade, the Eph receptors and ephrin ligands have emerged as key repulsive cues known to be involved in neurite outgrowth, synapse formation, and axonal pathfinding during development. Giv...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2007.03.015

    authors： Cruz-Orengo L,Figueroa JD,Torrado A,Puig A,Whittemore SR,Miranda JD

    更新日期：2007-05-11 00:00:00

  • Effect of insulin on serotonin, 5-hydroxyindole-acetic acid, norepinephrine, epinephrine and corticosterone contents in chick.

    abstract：:Pineal serotonin (5-HT), 5-hydroxyindole-acetic acid (5-HIAA), norepinephrine (NE), epinephrine (E) and adrenal corticosterone, NE and E contents were measured spectrofluorometrically 5, 15, 30 and 60 min after insulin treatment to induce hypoglycemic stress. In the pineal gland, hypoglycemic stress caused dramatic de...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(91)90662-d

    authors： Mahata SK

    更新日期：1991-01-02 00:00:00

  • Spinal opioid receptors and inhibition of urinary bladder motility in vivo.

    abstract：:The effects of intrathecal injections of morphine and other opioid receptor selective drugs were tested on urinary bladder contractions in the anesthetized rat. Morphine produced dose-related inhibition of bladder motility which was abolished by naloxone. This action was also observed with mu- and delta-opioid recepto...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(84)90390-2

    authors： Dray A,Metsch R

    更新日期：1984-06-01 00:00:00

  • Alzheimer's disease susceptibility genes modify the risk of Parkinson disease and Parkinson's disease-associated cognitive impairment.

    abstract：:The pathogenic mechanism underlying Parkinson's disease (PD) and PD- Cognitive impairment (CI) remains elusive. Its potential link to the risk factors in Alzheimer's disease (AD) is unclear. In this study, we analyzed 16 CE-associated single nucleotide polymorphisms (SNPs) in twelve genes in a Chinese cohort of 450 PD...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2018.04.042

    authors： Fang L,Tang BS,Fan K,Wan CM,Yan XX,Guo JF

    更新日期：2018-06-11 00:00:00

  • Strain difference in fear between spontaneously hypertensive and normotensive rats is mediated by adrenal cortical hormones.

    abstract：:In the present study we sought to determine whether the strain difference in fear reactivity between spontaneously hypertensive rats (SHR) and strain-matched WKY controls might be related to adrenocortical function. SHR and WKY were subjected to adrenalectomy prior to classical fear conditioning. Adrenal cortical ster...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(84)90199-x

    authors： Sakaguchi A,LeDoux JE,Sved AF,Reis DJ

    更新日期：1984-04-20 00:00:00

  • Arginine vasotocin activates phosphoinositide signal transduction system and potentiates N-acetyltransferase activity in the rat pineal gland.

    abstract：:The pineal gland is innervated by pinealopetal peptidergic fibers originating in the hypothalamic nuclei which release arginine vasopressin (AVP) and arginine vasotocin (AVT) from their endings. Since the mechanism of AVT action on the pineal signal transduction and melatonin synthesis has not been determined so far, ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(99)00066-x

    authors： Novotná R,Jác M,Hájek I,Novotný I

    更新日期：1999-03-05 00:00:00

  • Modulatory effects of ketamine on catecholamine efflux from in vivo cardiac sympathetic nerve endings in cats.

    abstract：:With the use of the microdialysis technique, we examined the modulatory effect of ketamine on catecholamine efflux from in vivo cardiac sympathetic nerve endings. A dialysis probe was implanted in the left ventricular myocardium, and dialysate norepinephrine (NE) levels in anesthetized cats were measured with liquid c...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(02)00208-2

    authors： Kitagawa H,Yamazaki T,Akiyama T,Yahagi N,Kawada T,Mori H,Sunagawa K

    更新日期：2002-05-24 00:00:00

  • Potassium channels moderate ectopic excitability of nerve-end neuromas in rats.

    abstract：:The potassium conductance (gK) blockers tetraethylammonium (TEA) and 4-aminopyridine (4-AP) strongly excited experimental neuromas that had spontaneous discharge, but had minimal effects on acutely cut nerves and on old, quiescent neuromas. Resting gK apparently moderates hyperexcitability in active neuromas. ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(83)90299-9

    authors： Devor M

    更新日期：1983-09-30 00:00:00

  • Exploring vocal recovery after cranial nerve injury in Bengalese finches.

    abstract：:Songbirds and humans use auditory feedback to acquire and maintain their vocalizations. The Bengalese finch (Lonchura striata domestica) is a songbird species that rapidly modifies its vocal output to adhere to an internal song memory. In this species, the left side of the bipartite vocal organ is specialized for prod...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2012.12.016

    authors： Urbano CM,Peterson JR,Cooper BG

    更新日期：2013-02-08 00:00:00

  • The nigro-striatal and nigro-amygdaloid pathways undergo different degeneration processes in brains of dementia with Lewy bodies.

    abstract：:We immunohistochemically investigated the degeneration processes of the nigro-striatal and nigro-amygdaloid pathways and the relationship between the loss of dopaminergic neurons and Lewy bodies (LB) formation in the substantia nigra using 15 autopsied cases of dementia with Lewy bodies (DLB). The number of tyrosine h...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2005.01.056

    authors： Iseki E,Marui W,Yamamoto R,Togo T,Katsuse O,Kato M,Iwatsubo T,Kosaka K,Arai H

    更新日期：2005-05-20 00:00:00

  • Acridinic acid: a new antagonist of amino acid-induced excitations of central neurones.

    abstract：:The actions of acridinic acid (2,3-quinoline dicarboxylic acid), a new derivative of quinolinic acid, as an antagonist of amino acid-induced excitations are described. Acridinate, like kynurenate, in the cerebral cortex reduced the effects of all amino acids equally, but in the spinal cord was significantly less activ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(86)90173-4

    authors： Curry K,Magnuson DS,McLennan H,Peet MJ

    更新日期：1986-05-06 00:00:00

  • Receptor desensitization and the transient nature of the secretory response of adrenal chromaffin cells.

    abstract：:Transition of the cellular responsiveness to a cholinergic stimulation during a prolonged stimulation with acetylcholine (ACh) of adrenal chromaffin cells was studied by directly monitoring the secretory process in cell bed perfusion experiments. A pulsatile injection of hexamethonium during the prolonged stimulation ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(86)90472-6

    authors： Ohara-Imaizumi M,Kumakura K

    更新日期：1986-10-08 00:00:00

  • Tyrosine augments clozapine-induced dopamine release in the medial prefrontal cortex of the rat in vivo: effects of access to food.

    abstract：:It has been reported that tyrosine administration augments clozapine-induced dopamine (DA) release in the medial prefrontal cortex (MPFC). To characterize this effect and exclude possible confounds, we conducted a series of studies in which microdialysate collection started 24 h after probe implantation, a time at whi...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2003.11.060

    authors： Jaskiw GE,Simpson C,Bongiovanni R,Yamamoto BK

    更新日期：2004-02-26 00:00:00

  • Characterization of trkB immunoreactive cells in the intermediolateral cell column of the rat spinal cord.

    abstract：:The objective of the present study was to characterize the trkB receptor immunoreactive (-ir) cells in the intermediolateral cell column (IML) of the upper thoracic spinal cord. Small trkB-ir cells (area=56.1+/-4.4 microm(2)) observed in the IML showed characteristics of oligodendrocytes and were frequently observed i...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2008.05.057

    authors： McCartney AM,Abejuela VL,Isaacson LG

    更新日期：2008-08-01 00:00:00

  • Asymmetric Fos labeling in lobule X of the cerebellum following transtympanic tetrodotoxin (TTX) in the rat.

    abstract：:Unilateral transtympanic administration of the sodium channel blocker tetrodotoxin (75 microl of 3 mM TTX in 0.1 M citrate buffer, pH 5.0) produced behavioral symptoms indicative of unilateral vestibular disruption. Following survival times of 2 and 24 h immunocytochemistry for Fos revealed asymmetric labeling in the ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/s0304-3940(02)01426-x

    authors： Saxon DW

    更新日期：2003-03-13 00:00:00

  • Beta rebound after different types of motor imagery in man.

    abstract：:We investigated the behavior of short-lasting beta bursts (beta rebound, beta ERS) induced after imagination of hand, foot or tongue movement. Nine able-bodied subjects were asked to imagine one type of movement following the presentation of a visual cue stimulus. EEG was recorded from 60 closely spaced electrodes pla...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2004.12.034

    authors： Pfurtscheller G,Neuper C,Brunner C,da Silva FL

    更新日期：2005-04-22 00:00:00

  • Ultrastructural studies of medullary synaptic inputs to vasopressin-immunoreactive neurons in the supraoptic nucleus of the rat hypothalamus.

    abstract：:Direct projections from the A1/C1 catecholaminergic cell group in the caudal ventrolateral medulla oblongata to neurons containing vasopressin (VP) in the supraoptic nucleus (SON) were studied electron microscopically by a double-labeling technique which combines anterograde tracing after injection of wheat germ agglu...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(92)90828-u

    authors： Shioda S,Shimoda Y,Nakai Y

    更新日期：1992-12-14 00:00:00

  • Taste cell formation does not require gustatory and somatosensory innervation.

    abstract：:Dependency of taste buds and taste papillae on innervation has been debated for a long time. Previous research showed neurotrophins, brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), play an important role for the establishment of the lingual gustatory and somatosensory innervation. BDNF null mutant ...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/j.neulet.2010.01.039

    authors： Ito A,Nosrat IV,Nosrat CA

    更新日期：2010-03-08 00:00:00

  • Dose ratio is important in maximizing naloxone enhancement of nalbuphine analgesia in humans.

    abstract：:The analgesic effect of kappa partial agonist opioids (i.e. nalbuphine, pentazocine and butorphanol) is significantly greater in women. Recent evidence suggests that this sexual dimorphism may result from a naloxone-sensitive anti-analgesic effect that is activated along with, and summates with, the analgesic effect o...

    journal_title：Neuroscience letters

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0304-3940(03)00939-x

    authors： Gear RW,Gordon NC,Miaskowski C,Paul SM,Heller PH,Levine JD

    更新日期：2003-11-06 00:00:00

  • Behavioural deficits in adult rats following long-term adrenalectomy.

    abstract：:Long-term adrenalectomy results in loss of neurones in the hippocampal formation of the adult rat. The effects of long-term adrenalectomy on spatial learning and exploratory behaviour in adrenalectomized (ADX), adrenalectomized normal weight gain (ADXNW), sham operated and naive control male Sprague-Dawley rats were i...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(95)11724-b

    authors： Islam A,Henriksson B,Mohammed A,Winblad B,Adem A

    更新日期：1995-07-14 00:00:00

  • Immunocytochemical demonstration of luteinizing hormone-releasing hormone in optic nerve and nasal region of fetal rhesus macaque.

    abstract：:The brain and nasal region of a fetal (124 days) female rhesus macaque (Macaca mulatta) were fixed in situ, decalcified, sectioned and treated for the immunocytochemical demonstration of LHRH. Immunoreactive neurons and fibers were found in expected sites and also in sites not reported to date in primates: there was a...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(87)90674-4

    authors： Witkin JW

    更新日期：1987-08-18 00:00:00

  • Positive correlation between contamination by blood and amino acid levels in cerebrospinal fluid of the rat.

    abstract：:The degree of contamination by blood in macroscopically clear cerebrospinal fluid (CSF) from the rat was assessed by the red blood cell count. Amino acid concentrations in the same samples were determined using high performance liquid chromatography. A significant positive correlation between the number of erythrocyte...

    journal_title：Neuroscience letters

    pub_type： 杂志文章

    doi：10.1016/0304-3940(86)90606-3

    authors： Kornhuber ME,Kornhuber J,Kornhuber AW,Hartmann GM

    更新日期：1986-08-29 00:00:00