Modulatory effects of ketamine on catecholamine efflux from in vivo cardiac sympathetic nerve endings in cats.


:With the use of the microdialysis technique, we examined the modulatory effect of ketamine on catecholamine efflux from in vivo cardiac sympathetic nerve endings. A dialysis probe was implanted in the left ventricular myocardium, and dialysate norepinephrine (NE) levels in anesthetized cats were measured with liquid chromatogram-electrical detection. A 60-min occlusion of the left anterior descending coronary artery caused increases in dialysate NE levels. Through the dialysis probe, locally applied ketamine (10 mM) augmented the dialysate NE responses to coronary occlusion in the presence and absence of desipramine (membrane NE transport blocker). Thus, the ketamine-induced NE increment is not mediated through the neuronal NE transporter. The sympathomimetic action of ketamine may augment the NE efflux evoked by myocardial ischemia.


Neurosci Lett


Neuroscience letters


Kitagawa H,Yamazaki T,Akiyama T,Yahagi N,Kawada T,Mori H,Sunagawa K





Has Abstract


2002-05-24 00:00:00














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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Grassi C,Magnelli V,Carabelli V,Sher E,Carbone E

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  • Edaravone-caffeine combination for the effective management of rotenone induced Parkinson's disease in rats: An evidence based affirmative from a comparative analysis of behavior and biomarker expression.

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Bandookwala M,Sahu AK,Thakkar D,Sharma M,Khairnar A,Sengupta P

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  • Absence of center of mass control for leg abduction in long-term weightlessness in humans.

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Pedrocchi A,Baroni G,Mouchnino L,Ferrigno G,Pedotti A,Massion J

    更新日期:2002-02-22 00:00:00

  • Autoradiographic study of the cellular localization of [3H]glibenclamide binding sites in the rat hippocampus.

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Tremblay E,Zini S,Ben-Ari Y

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Johnston JM,Burnett P,Thomas AP,Tezapsidis N

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Li Y,Hu GY

    更新日期:2002-08-30 00:00:00

  • Rewarding and reinforcing effects of 4-chloro-2,5-dimethoxyamphetamine and AH-7921 in rodents.

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Cha HJ,Jeon SY,Jang HJ,Shin J,Kim YH,Suh SK

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  • Effects of maternal protein malnutrition on oxidative markers in the young rat cortex and cerebellum.

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Bonatto F,Polydoro M,Andrades ME,Conte da Frota ML Jr,Dal-Pizzol F,Rotta LN,Souza DO,Perry ML,Fonseca Moreira JC

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Lindsay RM,Tarbit J

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  • The human supplementary motor area-proper does not receive direct somatosensory inputs from the periphery: data from stereotactic depth somatosensory evoked potential recordings.

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Barba C,Valeriani M,Restuccia D,Colicchio G,Faraca G,Tonali P,Mauguière F

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Konishi A,Itoh K,Sugimoto T,Yasui Y,Kaneko T,Takada M,Mizuno N

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Rybnikova E,Tulkova E,Pelto-Huikko M,Samoilov M

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Mizuno Y,Suzuki K,Sone N,Saitoh T

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  • Voltage-clamp analysis of the voltage-gated sodium current of the rat pituitary melanotroph.

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Khavandgar S,Homayoun H,Dehpour AR

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Chan AS,Cheung M,Ho Y,Jing He W

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Ghassemifar S,Mendrysa SM

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Zuazo A,Zapata P

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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


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    journal_title:Neuroscience letters

    pub_type: 杂志文章


    authors: Yau JL,Noble J,Hibberd C,Seckl JR

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