Modulatory effects of ketamine on catecholamine efflux from in vivo cardiac sympathetic nerve endings in cats.

abstract：:IgGs from two LEMS patients applied to human neuroblastoma IMR32 cells reduced the density of low- (LVA; T) and high-threshold (HVA; L and N) Ba2+ currents by different percentages: 36% (LVA) and 56% (HVA) for one and 48% and 45% for the other. A pharmacological assay of IgGs action based on the block of L-type channe...

journal_title：Neuroscience letters

authors： Grassi C,Magnelli V,Carabelli V,Sher E,Carbone E

更新日期：1994-11-07 00:00:00

abstract：:Restoration of cellular microenvironment is important in the treatment of neurodegenerative diseases for optimal functioning and survival of neurons. Oxidative stress has been proposed as one of the major pathogenic drivers in Parkinson's disease. Parkinson's model was developed by chronic administration of a pesticid...

journal_title：Neuroscience letters

authors： Bandookwala M,Sahu AK,Thakkar D,Sharma M,Khairnar A,Sengupta P

更新日期：2019-10-15 00:00:00

abstract：:The present investigation describes for the first time leg lateral abduction performance during long-term microgravity exposure. Two astronauts took part in the experiments, starting 2 weeks into the mission and lasting for 5 months. Results on joint angles kinematics confirm previous investigations on parabolic fligh...

journal_title：Neuroscience letters

authors： Pedrocchi A,Baroni G,Mouchnino L,Ferrigno G,Pedotti A,Massion J

更新日期：2002-02-22 00:00:00

abstract：:[3H]Glibenclamide, a potent ATP-sensitive K+ channel blocker, is a specific ligand for the identification of the sulfonylureas receptors which are closely related to ATP-sensitive K+ channels. In order to determine the pre- or postsynaptic localization of these receptors in the rat hippocampus, we studied the effects ...

journal_title：Neuroscience letters

authors： Tremblay E,Zini S,Ben-Ari Y

更新日期：1991-06-10 00:00:00

abstract：:Stimulation of type-1 astrocytes, by a number of agonists, has been shown to increase cytosolic Ca2+ concentrations in an oscillatory manner. However, it is unknown how these are driven or altered by aging, injury or disease. Therefore, we characterized the signaling properties of rat type-1 astrocytes in monolayer cu...

journal_title：Neuroscience letters

authors： Johnston JM,Burnett P,Thomas AP,Tezapsidis N

更新日期：2006-03-06 00:00:00

abstract：:The actions of huperzine A (HupA), a novel cholinesterase inhibitor, on the sustained potassium current were investigated in acutely dissociated hippocampal neurons of rat. HupA inhibited the current (IC(50) = 856 +/- 1 microM) with voltage-dependency. The effect was insensitive to 3 microM atropine. Tacrine (IC(50) =...

journal_title：Neuroscience letters

authors： Li Y,Hu GY

更新日期：2002-08-30 00:00:00

abstract：:New psychoactive substances (NPSs), i.e., newly designed substances with chemical residues that are slightly different from those of known psychoactive substances, have been emerging since the late 2000s, and social problems related to the use of these substances are increasing globally. Two such NPSs are 4-chloro-2,5...

journal_title：Neuroscience letters

authors： Cha HJ,Jeon SY,Jang HJ,Shin J,Kim YH,Suh SK

更新日期：2018-05-29 00:00:00

abstract：:Malnutrition affects a large number of children worldwide. Inadequate nutrition during pre- and postnatal period may alter brain development resulting in biochemical, physiological and anatomical changes which in turn could cause behavioral abnormalities. The impairment of the central nervous system following protein ...

journal_title：Neuroscience letters

authors： Bonatto F,Polydoro M,Andrades ME,Conte da Frota ML Jr,Dal-Pizzol F,Rotta LN,Souza DO,Perry ML,Fonseca Moreira JC

更新日期：2006-10-09 00:00:00

abstract：:Neurite outgrowth is elicited from whole explants or dissociated neurons of 8--10-day-old chick embryo sensory, dorsal root ganglia when cultured in the presence of a high speed supernatant fraction (105,000 g) from homogenates of chick or rat heart, liver or brain. The neurite promoting activity is not identical to m...

journal_title：Neuroscience letters

authors： Lindsay RM,Tarbit J

更新日期：1979-05-01 00:00:00

abstract：:Somatosensory evoked potentials to median nerve (MN) stimulation were recorded by stereotactically implanted electrodes in the frontal lobe of two epileptic patients in order to evaluate whether short-latency cortical responses could be generated in the supplementary motor area (SMA)-proper. In both patients two poten...

journal_title：Neuroscience letters

authors： Barba C,Valeriani M,Restuccia D,Colicchio G,Faraca G,Tonali P,Mauguière F

更新日期：2003-07-03 00:00:00

abstract：:Leucine-enkephalin-like immunoreactive (ENK-LI) afferent fibers to the feline homologue of the Onuf's nucleus (pudendal motoneurons) originate mainly from lamina X of the sacral cord. They make synaptic contacts chiefly upon dendrites of pudendal motoneurons; the synaptic terminals most often contain pleomorphic synap...

journal_title：Neuroscience letters

authors： Konishi A,Itoh K,Sugimoto T,Yasui Y,Kaneko T,Takada M,Mizuno N

更新日期：1985-10-24 00:00:00

abstract：:The effect of preconditioning (PC) on the changes of nerve growth factor-induced gene A (NGFI-A) expression induced by severe hypobaric hypoxia was studied by in situ hybridization. A PC consisted of three trials of mild hypobaric hypoxia (360 Torr, 2 h) spaced at 24 h. The last trial was followed by severe hypoxia (S...

journal_title：Neuroscience letters

authors： Rybnikova E,Tulkova E,Pelto-Huikko M,Samoilov M

更新日期：2002-08-23 00:00:00

abstract：:Effect of 1-methyl-4-phenylpyridinium ion (MPP+) on adenosine triphosphate (ATP) synthesis was studied using isolated mitochondrial preparations from mouse brains. Oxidation of glutamate + malate in the mitochondria estimated by polarography was significantly inhibited by MPP+, and synthesis of ATP was inhibited to ap...

journal_title：Neuroscience letters

authors： Mizuno Y,Suzuki K,Sone N,Saitoh T

更新日期：1987-10-16 00:00:00

abstract：:By using the whole-cell recording technique the Na+ current in cultured melanotrophs of the adult rat pituitary was studied. The Na+ current was eliminated by 1 microM TTX and its equilibrium potential confirmed that it was carried predominantly by Na+. The activation threshold was near -40 mV and half-maximal activat...

journal_title：Neuroscience letters

authors： Kehl SJ

更新日期：1994-01-03 00:00:00

abstract：:The involvement of nitric oxide (NO) in modulation of seizure susceptibility by delta-opioid agonist (+)-4-((alpha R)-alpha-((2S, 5R)-4-allyl-2, 5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N, N-diethyl-benzamide (SNC80) was examined in mice. Systemic administration of SNC80 (0.1-5 mg/kg, intraperitoneally (i.p.)) decre...

journal_title：Neuroscience letters

authors： Khavandgar S,Homayoun H,Dehpour AR

更新日期：2002-08-30 00:00:00

abstract：:GABAergic modulation of enkephalin, substance P and glutamic acid decarboxylase (GAD67) gene expression and the alterations induced by dopamine receptor blockade were studied in the rat striatum. Following subchronic treatment with the GABA-A agonist muscimol, the GABA-B agonist baclofen or the GABA transaminase inhib...

journal_title：Neuroscience letters

authors： Jolkkonen J,Jenner P,Marsden CD

更新日期：1994-10-24 00:00:00

abstract：:Neuroimaging studies have identified cognitive tasks that can selectively activate specific parts of the brains. However, the subsequent effect of localized brain activation on the cognitive functioning remains unclear. We discovered that after being engaged in the novel picture encoding task to activate hippocampus f...

journal_title：Neuroscience letters

authors： Chan AS,Cheung M,Ho Y,Jing He W

更新日期：2000-04-07 00:00:00

abstract：:The role of G-proteins in the mediation of the cardiovascular effects of neuropeptide Y and the alpha 2-adrenoceptor agonist clonidine was investigated by injections of pertussis toxin (10 micrograms/30 microliters, i.v.t., 24 h) in the awake unrestrained male rat. Treatment with pertussis toxin was found to inhibit t...

journal_title：Neuroscience letters

authors： Fuxe K,von Euler G,van der Ploeg I,Fredholm BB,Agnati LF

更新日期：1989-07-03 00:00:00

abstract：:A comparison of cholecystokinin (CCK) receptor binding to sections of rat, mouse and guinea pig brain has been performed using 125I-Bolton Hunter CCK and the selective peripheral CCK receptor antagonist L-365,031. In both rat and mouse, 125I-Bolton Hunter CCK binding in the region of the interpeduncular nucleus (IPN) ...

journal_title：Neuroscience letters

authors： Hill DR,Shaw TM,Woodruff GN

更新日期：1987-08-31 00:00:00

abstract：:The AMPA receptor subunit GluR2 is downregulated in neurons following a wide range of neurological insults. Here we report that suppression of GluR2 gene promoter activity is associated with kainate (KA)-induced downregulation of GluR2 subunit levels in primary cultured cortical neurons. RT-PCR and Northern blotting s...

journal_title：Neuroscience letters

authors： Jia YH,Zhu X,Li SY,Ni JH,Jia HT

更新日期：2006-07-31 00:00:00

abstract：:Comparable to the anti-craving compound acamprosate, caroverine reduces alcohol withdrawal symptoms by an antagonism at ionotropic glutamate receptors and a blockade of calcium channels. The present study examines the effect of caroverine in a craving model, in which acamprosate has proved effective before. A place av...

journal_title：Neuroscience letters

authors： Kratzer U,Schmidt WJ

更新日期：2003-10-02 00:00:00

abstract：:After traumatic brain injury (TBI), the primary insult is followed by a cascade of secondary events which lead to enlargement of the primary lesion and are potentially amenable to therapeutic intervention. Lisuride is a dopaminergic agonist with additional serotoninergic, adrenergic, and glutamate antagonistic propert...

journal_title：Neuroscience letters

authors： Zweckberger K,Simunovic F,Kiening KL,Unterberg AW,Sakowitz OW

更新日期：2011-07-25 00:00:00

abstract：:The present study investigated the changes in the expression of regulators of G-protein-coupled signaling proteins RGS2, 7 and 8 in gerbil hippocampus to better understand alterations of G-protein-coupled receptors signaling after cerebral ischemia. In situ hybridization revealed a transient, robust early increase in ...

journal_title：Neuroscience letters

authors： Shelat PB,Coulibaly AP,Wang Q,Sun AY,Sun GY,Simonyi A

更新日期：2006-07-31 00:00:00

abstract：:It is known that over-exercise or forced running interrupts the regular ovulatory (estrous) cycle in female mammals, including women. The serotonin content of the brain changes under stress conditions. In this experiment, radiofrequency lesions were made in the dorsal (DRL) or median (MRL) raphe nuclei of the midbrain...

journal_title：Neuroscience letters

authors： Shimizu H,Yamanouchi K

更新日期：2011-05-20 00:00:00

abstract：:A critical component of the cellular stress response, the p53 tumor suppressor protein must be functional for many cancer therapies to be effective. Adjuvant therapies that augment p53 function are predicted to sensitize tumor cells to cancer therapies that rely upon p53 for their efficacy. Of those strategies current...

journal_title：Neuroscience letters

authors： Ghassemifar S,Mendrysa SM

更新日期：2012-03-28 00:00:00

abstract：:The effect of sex, postmortem delay and aging on alpha 2-adrenoceptor binding was studied in tissue sections from several representative regions of the human brain from 21 subjects using [3H]UK-14304 as a ligand. Sex and postmortem delay did not influence the density of alpha 2-receptors. Aging resulted in clear decre...

journal_title：Neuroscience letters

authors： Pascual J,del Arco C,González AM,Díaz A,del Olmo E,Pazos A

更新日期：1991-12-09 00:00:00

abstract：:Spontaneous gasps were recorded in pentobarbitone-anesthetized adult cats. Mean interval between gasps in 11 cats with their buffer nerves intact was of 65 sec; it was significantly prolonged to 174 sec after unilateral carotid neurotomy and to 403 sec after bilateral carotid neurotomy. Additional sectioning of both a...

journal_title：Neuroscience letters

authors： Zuazo A,Zapata P

更新日期：1980-01-01 00:00:00

abstract：:The magnetic cell sorter (MACS) technique was applied to isolate retinal ganglion cells (RGCs) for culture. RGCs were labeled retrogradely with 1.1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate (Dil). Subsequently retinal cell suspensions were incubated with biotinylated anti-rat Thy-1 antibody and MA...

journal_title：Neuroscience letters

authors： Shoge K,Mishima HK,Mukai S,Shinya M,Ishihara K,Kanno M,Sasa M

更新日期：1999-01-08 00:00:00

abstract：:The cyclic AMP/protein kinase A signaling pathway is thought to be involved in neural differentiation of mesenchymal stem cells. In the present study, we examined the involvement of β-adrenoceptor signaling on the differentiation of mouse induced pluripotent stem (iPS) cells into neural progenitor cells. Mouse iPS cel...

journal_title：Neuroscience letters

authors： Ishizuka T,Goshima H,Ozawa A,Watanabe Y

更新日期：2012-09-06 00:00:00

abstract：:Chronic treatment with antidepressant drugs (2 weeks or longer) increases corticosteroid receptor mRNA expression in the hippocampus and reduces hypothalamic-pituitary-adrenal axis activity in parallel with improving mood and neuroendocrine function. Earlier effects are less well documented. We examined the effects of...

journal_title：Neuroscience letters

authors： Yau JL,Noble J,Hibberd C,Seckl JR

更新日期：2001-06-29 00:00:00