Alzheimer's disease susceptibility genes modify the risk of Parkinson disease and Parkinson's disease-associated cognitive impairment.

abstract：:Since the rubro-olivary projection has not been demonstrated in the rat, unlike the monkey and cat (refs. in text). HRP or highly-concentrated wheat germ agglutinin-horseradish peroxidase (WGA-HRP) was injected into the inferior olivary nucleus using a ventral approach. After processing with a modified technique, sect...

journal_title：Neuroscience letters

authors： Kennedy PR

更新日期：1987-03-09 00:00:00

abstract：:Using scanning electron microscopy (SEM), we encountered a new phenomenon in developing olfactory structures. A few cells with single slender processes that sprout from their cell bodies were found lying on the surface of the developing olfactory epithelium in 15 and 16 day old rat embryos. These slender processes res...

journal_title：Neuroscience letters

authors： Menco BP,Jackson JE

更新日期：1997-12-19 00:00:00

abstract：:The polymerase chain reaction was utilized to determine which of six cloned phospholipase A2 (PLA2) messenger RNAs (mRNAs), encoding four distinct low molecular weight forms of secretory PLA2 (PLA2-IB, PLA2-IIA, PLA2-IIC and PLA2-V), a calcium-dependent high molecular weight PLA2 (PLA2-IV, cPLA2) and a calcium-indepen...

journal_title：Neuroscience letters

authors： Molloy GY,Rattray M,Williams RJ

更新日期：1998-12-24 00:00:00

abstract：:Neovascularization of the dissociated central nervous tissue transplanted into the lateral ventricle of the rat was studied using laminin immunohistochemistry. A very high immunoreactive response to laminin was demonstrated in the presumably newly formed vessels within the transplants and the graft-host borders. The g...

journal_title：Neuroscience letters

authors： Shigematsu K,Kamo H,Akiguchi I,Kameyama M,Kimura H

更新日期：1989-04-24 00:00:00

abstract：:A traditional analysis of intra-encephalic auditory evoked potentials does not highlight the dynamical evolution of the auditory 'information' processing in neither time nor space. This work presents a method for tracing such signal evolution throughout the primary auditory pathway in the mesencephalon of adult anesth...

journal_title：Neuroscience letters

authors： Moraes MF,Del Vecchio F,Terra VC,Garcia-Cairasco N

更新日期：2000-04-21 00:00:00

abstract：:Motoneuron death induced by sciatic nerve transection in neonatal rats has been related to induction of the neuronal isoform of nitric oxide synthase (nNOS), a diaphorase of which one of the cofactors is nicotinamide adenine dinucleotide phosphate (NADPH). We transected the sciatic nerve of neonatal rats (P2) and exam...

journal_title：Neuroscience letters

authors： Rogério F,Teixeira SA,de Souza Queiroz L,De Nucci G,Langone F

更新日期：2001-07-13 00:00:00

abstract：:The effect of carbachol on the excitatory synaptic transmission was studied in rat neostriatal neurons using intracellular and whole-cell voltage clamp-recording methods. Depolarizing excitatory postsynaptic potentials (EPSPs) were evoked by cortical stimulation. Superfusion of carbachol (0.01-3 microM) reversibly dec...

journal_title：Neuroscience letters

authors： Hsu KS,Huang CC,Gean PW

更新日期：1995-09-08 00:00:00

abstract：:Neuroglobin (Ngb) is a novel vertebrate globin expressed principally in neurons. Ngb expression is induced by hypoxia and ischemia, and Ngb protects neurons against these insults. The mechanism of Ngb's protective action is unknown, but its ability to bind NO suggests that NO scavenging might be involved. To test this...

journal_title：Neuroscience letters

authors： Jin K,Mao XO,Xie L,Khan AA,Greenberg DA

更新日期：2008-01-10 00:00:00

abstract：:Learning is important for humans and can be disrupted by disease. However, the essence of how learning may be represented within a neuronal network is still elusive. Spike trains generated by neurons have been demonstrated to carry information which is relevant for learning. The present study uses well-established mut...

journal_title：Neuroscience letters

authors： Jog MS,Aur D,Connolly CI

更新日期：2007-01-22 00:00:00

abstract：:In this review, we summarize the recent development of positron emission tomography (PET) radioligands for γ-aminobutyric acid A (GABAA) receptors and their potential to measure changes in endogenous GABA levels and highlight the clinical and translational applications of GABA-sensitive PET radioligands. We review the...

journal_title：Neuroscience letters

authors： Andersson JD,Matuskey D,Finnema SJ

更新日期：2019-01-19 00:00:00

abstract：:Rat pineal glands incubated in vitro with 10 or 100 microM norepinephrine (NE) released 51% and 415% more prostaglandin E2 (PGE2) to the medium than in the absence of NE. Phentolamine (10 microM) prevented fully the effect of NE at both concentrations, whereas propranolol failed to affect it significantly. After super...

journal_title：Neuroscience letters

authors： Ritta MN,Cardinali DP

更新日期：1982-08-31 00:00:00

abstract：:Continuous use of crack induces hyperalgesia which is related to drug tolerance. Despite cumulative evidence based on the growth rate of crack abuse, no serious study has been focused on the mechanisms of crack-induced hyperalgesia. This study aimed to elucidate whether extracellular signal-regulated kinases (Erk1/2)/...

journal_title：Neuroscience letters

authors： Aberoumandi SM,Vousooghi N,Tabrizi BA,Karimi P

更新日期：2019-04-17 00:00:00

abstract：:The effects of oral dexnorfenfluramine (DNF; 1-4 mg/kg, twice daily for 4 days), the active metabolite of dexfenfluramine, were examined on rat regional brain indole contents and [3H]citalopram binding. Two hours after the last dose, serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) were dose-dependently lowere...

journal_title：Neuroscience letters

authors： Gobbi M,Bergami A,Caltavuturo C,Valle FD,Mennini T,Caccia S

更新日期：1996-11-15 00:00:00

abstract：:When locally infused, the potent vasoconstrictor, endothelin-1 (ET-1) produces partial ischemic damage in many regions of the brain, including the hippocampus. The hippocampus is known for a high density of glucocorticoid receptors and for the potent actions of stress and corticosterone to modulate function. The curre...

journal_title：Neuroscience letters

authors： Faraji J,Lehmann H,Metz GA,Sutherland RJ

更新日期：2009-10-25 00:00:00

abstract：:There are many evidences suggest that ascorbate in the extracellular space can affect glutamate concentration in the rat's brain. In this report, we studied how ascorbate in microdialysis perfusion medium affected glutamate level at the striatum in freely-moving rats. Three perfusion mediums were used: 0, 250, and 400...

journal_title：Neuroscience letters

authors： Lai YJ,Shen EY,Pan WH

更新日期：2000-02-04 00:00:00

abstract：:We have identified the secretory cleavage site in the Alzheimer amyloid precursor (APP) in a non-transfected neuronal cell line, using cyanogen bromide digests of APP purified from medium conditioned by PC-12 cells which were differentiated to a neuronal phenotype. The results obtained are most consistent with proteol...

journal_title：Neuroscience letters

authors： Anderson JP,Esch FS,Keim PS,Sambamurti K,Lieberburg I,Robakis NK

更新日期：1991-07-08 00:00:00

abstract：:Repeated exposure to dizocilpine (MK-801) can be used as a model of schizophrenia that incorporates disease progression. Proton magnetic resonance spectroscopy (1H MRS) has been widely used to investigate schizophrenia-related alterations in glutamate (Glu). The purpose of this study was to investigate metabolic alter...

journal_title：Neuroscience letters

authors： Yoo CH,Song KH,Lim SI,Lee DW,Woo DC,Choe BY

更新日期：2017-01-10 00:00:00

abstract：:Ethanol withdrawal is a serious clinical problem owing in part to over stimulation of ionotropic glutamate receptors in the brain and is linked to elevated oxidative damage. In this study, we tested the hypothesis that lipid peroxidation is elevated in the brain tissue of rats fed an ethanol-containing diet for 6 week...

journal_title：Neuroscience letters

authors： Milne GL,Morrow JD,Picklo MJ Sr

更新日期：2006-09-25 00:00:00

abstract：:Auditory evoked potentials (AEPs) were recorded during presentation of stimuli of 1000 Hz (standard) and 2000 Hz (deviant) in trains of 10 tone bursts (one deviant per train) in the wake and rapid eye movement (REM) sleep states. The constant inter-stimulus interval (ISI) was 600 ms and the trains were separated by 3 ...

journal_title：Neuroscience letters

authors： Atienza M,Cantero JL,Gómez CM

更新日期：1997-11-14 00:00:00

abstract：:Transition of the cellular responsiveness to a cholinergic stimulation during a prolonged stimulation with acetylcholine (ACh) of adrenal chromaffin cells was studied by directly monitoring the secretory process in cell bed perfusion experiments. A pulsatile injection of hexamethonium during the prolonged stimulation ...

journal_title：Neuroscience letters

authors： Ohara-Imaizumi M,Kumakura K

更新日期：1986-10-08 00:00:00

abstract：:Spontaneous openings of acetylcholine receptor channels were investigated using Xenopus myotomal muscle cells in culture and patch clamp recording methods. Two classes of channels with conductances close to 40 and 60 pS and reversal potentials near 0 mV were found to open in the absence of agonist. The open time of th...

journal_title：Neuroscience letters

authors： Rojas L,Zuazaga C

更新日期：1991-04-01 00:00:00

abstract：:Using retrograde transport of Fluoro-Gold (FG) combined with immunofluorescence for phenylethanolamine-N-methyltransferase (PNMT), we have examined afferents to the nucleus locus coeruleus (LC) from the rostral ventrolateral medulla (nucleus paragigantocellularis; PGi) in rats sustaining lesions of the medullary adren...

journal_title：Neuroscience letters

authors： Astier B,Van Bockstaele EJ,Aston-Jones G,Pieribone VA

更新日期：1990-10-16 00:00:00

abstract：:Behavioral responses and neural responses in the somatosensory cortex were recorded in nine rabbits during the unpaired and paired treatments of classical eyeblink conditioning with a tone conditioned stimulus (CS) and an airpuff unconditioned stimulus. During the unpaired treatment, neither the behavioral nor neural ...

journal_title：Neuroscience letters

authors： Wikgren J,Ruusuvirta T,Korhonen T

更新日期：2003-05-01 00:00:00

abstract：:The p53 gene is mutated in pluripotential human neuroectodermal tumor DAOY cells which express both glial and neuronal markers. In most cells, nuclear m-p53 immunostaining was intense while cytoplasmic glial specific proteins (GSPs) were present at low levels. Conversely, glial fibrillary acidic protein (GFAP) and glu...

journal_title：Neuroscience letters

authors： U HS,Banaie A,Rigby L,Chen J

更新日期：1998-03-06 00:00:00

abstract：:In our horseradish peroxidase (HRP) study of the afferents to the medullary raphe nuclei in the cat, HRP uptake by damaged axons en route to the inferior olive (IO) was thought to be responsible for retrograde labelling of specific midbrain nuclei. To control for such indirect labelling, HRP was injected iontophoretic...

journal_title：Neuroscience letters

authors： Abols IA,Basbaum AI

更新日期：1979-07-01 00:00:00

abstract：:It has been shown that orexin neuropeptides contribute to morphine-induced physical dependence. The locus coeruleus (LC), which receives a dense extra-hypothalamic orexinergic projection, is a key brain region implicated in the expression of somatic signs of morphine withdrawal syndrome. The aim of the present study i...

journal_title：Neuroscience letters

authors： Azizi H,Mirnajafi-Zadeh J,Rohampour K,Semnanian S

更新日期：2010-10-04 00:00:00

abstract：:Spinocerebellar ataxia type 2 (SCA2) is associated with an expansion of CAG/polyglutamine-repeat of a gene of unknown function. We performed an immunohistochemical study to identify the immunolocalization of the disease protein ataxin-2 in normal and SCA2 patients. Although normal and expanded ataxin-2 were ubiquitous...

journal_title：Neuroscience letters

authors： Koyano S,Uchihara T,Fujigasaki H,Nakamura A,Yagishita S,Iwabuchi K

更新日期：1999-10-01 00:00:00

abstract：:Cerebral ischemia induces rapid efflux of glutamate into the extracellular space contributing to excessive activation of glutamate receptors in postsynaptic cells, particularly N-methyl-D-aspartate (NMDA) receptors, which triggers the neuron lesion through calcium overload. Our studies indicated that cerebral ischemia...

journal_title：Neuroscience letters

authors： Guo J,Meng F,Fu X,Song B,Yan X,Zhang G

更新日期：2004-01-30 00:00:00

abstract：:A valinomycin-based membrane phase for microelectrodes with relatively low electrical membrane resistances is described. Microelectrodes with tip diameters of about 1 micron exhibit resistances of about 10(10) omega. Extremely high K+ selectivities are obtained, e.g. a rejection of Na+ by a factor of 5000 and of acety...

journal_title：Neuroscience letters

authors： Ammann D,Chao PS,Simon W

更新日期：1987-02-24 00:00:00

abstract：:Outcome following traumatic brain injury (TBI) is in large part determined by the combined action of multiple processes. In order to better understand the response of the central nervous system to injury, we utilized an antibody array to simultaneously screen 507 proteins for altered expression in the injured hippocam...

journal_title：Neuroscience letters

authors： Redell JB,Dash PK

更新日期：2007-02-08 00:00:00