Abstract：
:Chronic social defeat stress in mice significantly decreases subsequent social interactions and induces other depression-like behaviors. Here we measured and manipulated levels of acetylated histone H3 (acH3), a chromatin mark of transcriptional activation, in the hippocampus and amygdala after ten continuous days of social defeat stress in male C57/Bl6J mice. This form of social stress causes a transient increase, followed by a persistent decrease, in the levels of acH3 in hippocampus. By comparison, increased acH3 in amygdala was more robust but also highly transient. The persistent decrease in acH3 in hippocampus may be pathological, since it is reversed by chronic fluoxetine administration. Consistent with this hypothesis, infusion of a histone deacetylase (HDAC) inhibitor MS-275 (100 μM) into hippocampus reverses a defeat-induced deficit in sucrose preference, although it does not restore social interaction behavior. Next, different forms of social enrichment were examined with or without hippocampal infusion of MS-275. After social stress, simple pair-housing with another male C57, or female C57, mouse does not reverse social avoidance. However, when HDAC inhibitors are infused into hippocampus during social housing with another male, social avoidance is attenuated. Interestingly, social avoidance is reversed when MS-275 is infused directly into amygdala. Together, these findings further support the antidepressant potential of HDAC inhibitors, and indicate that temporally overlapping environmental and molecular events are required to optimally reverse specific stress-induced behavioral symptoms.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Covington HE 3rd,Vialou VF,LaPlant Q,Ohnishi YN,Nestler EJdoi
10.1016/j.neulet.2011.02.022subject
Has Abstractpub_date
2011-04-15 00:00:00pages
122-6issue
3eissn
0304-3940issn
1872-7972pii
S0304-3940(11)00179-0journal_volume
493pub_type
杂志文章abstract：:In vivo rates of incorporation and turnover of palmitate and arachidonate in brain phospholipids were measured in awake rats treated chronically with lithium, following intravenous infusion of radiolabeled palmitate and arachidonate, respectively. Chronic lithium, at a brain level considered to be therapeutic in human...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(96)13264-x
更新日期：1996-12-20 00:00:00
abstract：:We have conjectured that axons embody a post transcriptional sprouting programme repressed by mature Schwann cells. Injured nerves of Wld(s) mice neither degenerate nor regenerate for several weeks but axons do regrow if the resident cells of the distal stump are destroyed. To test our hypothesis we made an extended c...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(99)00369-9
更新日期：1999-06-18 00:00:00
abstract：:Recently, researchers have developed protocols for human cerebral organoids using human pluripotent stem cells, which mimic the structure of the developing human brain. Existing research demonstrated that human cerebral organoids which undergo short cultivation periods, contain astrocytes, neurons, and neural stem cel...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2018.01.040
更新日期：2018-03-23 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(82)90016-7
更新日期：1982-05-17 00:00:00
abstract：:The present study was undertaken to investigate whether benzodiazepine receptors are involved in either the anticonvulsant activity of phenytoin against supramaximal seizures or maximal threshold seizures induced by electroshock or the neurotoxicity of phenytoin. Ro 15-1788, a benzodiazepine receptor antagonist, rever...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(85)90505-1
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2009.05.074
更新日期：2009-09-04 00:00:00
abstract：:The IKK/NF-κB signalling pathway plays a predominant role in the regulation of inflammation and apoptosis in spinal cord injury (SCI). We have previously demonstrated that targeting of the IKK/NF-κB pathway improved the recovery of locomotor function by reducing the infiltration of inflammatory cells and apoptosis aft...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2013.03.004
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(88)90466-1
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(87)90286-2
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(00)01109-5
更新日期：2000-06-02 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2003.10.012
更新日期：2004-01-16 00:00:00
abstract：:In situ whole cell voltage clamp recordings of presumed folliculo-stellate cells were made in the intermediate lobe of the clawed toad Xenopus laevis. Lucifer Yellow fillings revealed, in addition to the small, spherical melanotropes, a population of larger cells with many processes that were, to a limited extent, dye...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(96)12602-1
更新日期：1996-05-03 00:00:00
abstract：:The human nervous system displays remarkable functional plasticity following long-term sensory deprivation. For example, the auditory cortex of congenitally deaf humans may start to process tactile information. To further explore this type of cross-modal plasticity, we examined the tactile accuracy of congenitally dea...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(01)01597-x
更新日期：2001-03-23 00:00:00
abstract：:Nitric oxide (NO) plays a role in the secondary damage after spinal cord (SC) injury. NO is produced by the activity of two classes of enzymes: calcium-dependent constitutive nitric oxide synthase (NOS) and calcium-independent inducible NOS. To determine the time course of both NOS activities after SC injury, 50 Wista...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(01)02540-x
更新日期：2002-02-22 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(88)90546-0
更新日期：1988-07-08 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(80)90023-3
更新日期：1980-03-01 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(90)90505-4
更新日期：1990-05-18 00:00:00
abstract：:Consummatory successive negative contrast (cSNC) occurs when animals exposed to an unexpected downshift from a high palatable reward (e.g., 32% sucrose solution) to a less preferred one (e.g., 4% sucrose solution) show an abrupt and transient suppression of the consummatory response, compared with control animals that...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2018.07.013
更新日期：2018-09-25 00:00:00
abstract：:Using the gerbil model of post-ischemic neuron death in the hippocampal CA1 region, it was recently shown that there is a strong down-regulation of voltage-gated Ca2+ influx in neurons examined at 2 days after the ischemic insult (Connor, J.A., Razani-Boroujerdi, S., Greenwood, A.C., Cormier, R.J., Petrozzino, J.J. an...
journal_title：Neuroscience letters
pub_type： 杂志文章
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更新日期：2000-06-02 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2019.03.040
更新日期：2019-06-21 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(81)90242-1
更新日期：1981-07-02 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2015.12.047
更新日期：2016-02-02 00:00:00
abstract：:Normal aging is associated with chronic oxidative stress. In the basal ganglia, oxidative stress may contribute to the increased risk of Parkinson's disease in the elderly. Neurons are thought to actively utilize compensatory defense mechanisms, such as heat shock proteins (HSPs), to protect from persisting stress. De...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2010.01.049
更新日期：2010-03-19 00:00:00
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journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2007.04.082
更新日期：2007-06-27 00:00:00
abstract：:The longest central nervous system (CNS) specific isoform of the major myelin-associated inhibitor of neurite growth, Nogo-A, has previously been shown to be expressed largely in oligodendrocytes. Using an antibody raised against a recombinant fusion protein comprising amino acids 223-399 of Nogo-A, we show in this re...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/s0304-3940(02)00528-1
更新日期：2002-08-16 00:00:00
abstract：:The localization of serotonin and non-serotonin-containing cell bodies in the interpeduncular nucleus of the rat that project to the hippocampal formation was studied using the technique of retrograde tracing of Granular Blue and immunohistochemistry on the same sections. The results indicate that the caudal magnocell...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(84)90256-8
更新日期：1984-09-28 00:00:00
abstract：:The projection of the substantia nigra-ventral tegmental area (SN-VTA) to the ipsilateral and contralateral caudate-putamen was studied with double-labeling fluorescence techniques in the albino rat. By combining glyoxylic acid histofluorescence with retrograde fluorescence tracers, we were able to determine that 93% ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(83)90044-7
更新日期：1983-10-10 00:00:00
abstract：:In this report, we describe an efficient and non-enzymatic method for isolating and culturing endothelial cells (ECs) from the nidus of surgically resected arteriovenous malformation (AVM) specimens. These cultured cells possessed typical phenotypic markers (i.e. von Willebrand factor and CD34), as well as morphologic...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2013.05.050
更新日期：2013-08-26 00:00:00
abstract：:The melanocortin receptor type 2 (MC2R or adrenocorticotropic hormone, ACTH receptor) gene (MC2R) encodes a protein involved in regulation of adrenal cortisol secretion, important in the physiological response to stressors. A variant of MC2R, -179A>G, results in reduction of promoter activity and less adrenal action. ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/j.neulet.2008.02.042
更新日期：2008-04-25 00:00:00
abstract：:Opioid kappa-agonists had much more potent inhibitory effects on the high K+-evoked Met-enkephalin release from rat brain slices than did the mu- or delta-agonists. The opioid kappa- antagonist, MR2266 enhanced the evoked release of Met-enkephalin to a greater extent than did mu- or delta-antagonists in vitro and had ...
journal_title：Neuroscience letters
pub_type： 杂志文章
doi：10.1016/0304-3940(87)90401-0
更新日期：1987-10-29 00:00:00
