Abstract：
:The longest central nervous system (CNS) specific isoform of the major myelin-associated inhibitor of neurite growth, Nogo-A, has previously been shown to be expressed largely in oligodendrocytes. Using an antibody raised against a recombinant fusion protein comprising amino acids 223-399 of Nogo-A, we show in this report that Nogo-A is also expressed in the cell body of a distinct set of CNS neurons. The antibody detects a single protein band of 220 kDa in rat brain lysate and neuroblastoma cell lysates. Immunofluorescent analyses reveal that Nogo-A is found largely in the endoplasmic reticulum of neuroblastoma cell lines SH-SY5Y and NIE-115. In the mouse CNS, Nogo-A can be found in specific subsets of neuronal cell bodies in addition to oligodendrocytes, but not glial fibrillary associated protein positive astrocytes or MAC-1 positive microglia. Our results provide a conclusive demonstration of the expression of Nogo-A in CNS neurons, which suggests that Nogo-A may have distinct endogenous roles in neurons other than its known ability to inhibit neurite growth.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Liu H,Ng CE,Tang BLdoi
10.1016/s0304-3940(02)00528-1keywords:
subject
Has Abstractpub_date
2002-08-16 00:00:00pages
257-60issue
3eissn
0304-3940issn
1872-7972pii
S0304394002005281journal_volume
328pub_type
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journal_title：Neuroscience letters
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