Abstract:
:Functional recovery after experimental stroke in rats is enhanced by environmental enrichment by stimulating plastic changes in brain regions outside the lesion, but the molecular mechanisms are not known. We investigated the effect of environmental enrichment after focal cerebral ischemia on cognitive recovery and hippocampal gene expression using microarray analysis. Rats placed in enriched environment (EE) for 1 month after middle cerebral artery occlusion (MCAo) showed significantly improved spatial memory in the Morris water maze compared to rats housed alone after MCAo. Microarray analysis suggested several EE-induced differences in neuronal plasticity-related genes, but these changes could not be confirmed by quantitative real-time PCR. This study highlights some of the potential problems associated with gene expression profiling of brain tissues. Further studies at earlier time points and in additional subregions of the brain are of interest in the search for molecular mechanisms behind EE-induced neuronal plasticity after ischemic stroke.
journal_name
Neurosci Lettjournal_title
Neuroscience lettersauthors
Rönnbäck A,Dahlqvist P,Svensson PA,Jernås M,Carlsson B,Carlsson LM,Olsson Tdoi
10.1016/j.neulet.2005.05.016keywords:
subject
Has Abstractpub_date
2005-09-09 00:00:00pages
173-8issue
2eissn
0304-3940issn
1872-7972pii
S0304-3940(05)00562-8journal_volume
385pub_type
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