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High ethanol tolerance in young adults is associated with the low-activity variant of the promoter of the human serotonin transporter gene.

Abstract：

:Central serotonergic neurotransmission has been implicated in the aetiology of ethanol tolerance and dependence. Cellular expression of the serotonin transporter and serotonin reuptake is modulated via a polymorphic, repetitive element in the 5'-flanking regulatory region of the serotonin transporter gene (5-HTTLPR). We report the association of the low-activity, short variant of the 5-HTTLPR with high ethanol tolerance among young adults in a case-control association study (n = 713). The low-activity 5-HTTLPR showed a significantly increased allele frequency (chi2 = 7.30; df = 2; P = 0.007) and genotype frequency among young adults (< or =26 years) with high ethanol tolerance homozygous for the short allele (chi2 = 7.58; df = 1; P = 0.02). The estimated odds ratio for the homozygous short variant compared to the homozygous long variant was 2.82 (95% CI 1.30-6.11). This indicates that the low-activity 5-HTTLPR may be involved in the neuronal mechanisms responsible for ethanol tolerance and dependence.

journal_name

Neurosci Lett

journal_title

Neuroscience letters

authors

Türker T,Sodmann R,Goebel U,Jatzke S,Knapp M,Lesch KP,Schuster R,Schütz H,Weiler G,Stöber G

doi

10.1016/s0304-3940(98)00347-4

subject

Has Abstract

pub_date

1998-06-05 00:00:00

pages

147-50

issue

3

eissn

0304-3940

issn

1872-7972

pii

S0304394098003474

journal_volume

248

pub_type

杂志文章

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